scholarly journals Ethanol affects the generation, cosignaling molecule expression, and function of plasmacytoid and myeloid dendritic cell subsets in vitro and in vivo

2006 ◽  
Vol 79 (5) ◽  
pp. 941-953 ◽  
Author(s):  
Audrey H. Lau ◽  
Masanori Abe ◽  
Angus W. Thomson
Keyword(s):  
Dendritic Cell ◽  
Myeloid Dendritic Cell ◽  
Dendritic Cell Subsets ◽  
And Function

scholarly journals High-Resolution Profiling of Innate Immune Responses by Porcine Dendritic Cell Subsets in vitro and in vivo

2020 ◽  
Vol 11 ◽  
Author(s):  
Gaël Auray ◽  
Stephanie C. Talker ◽  
Irene Keller ◽  
Sylvie Python ◽  
Markus Gerber ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
High Resolution ◽  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Dendritic Cell Subsets

IN VITRO AND IN VIVO INVESTIGATIONS ON THE EFFECTS OF CYCLOSPORINE ON HUMAN DENDRITIC CELL SUBSETS

2004 ◽  
Vol 78 ◽  
pp. 601-602
Author(s):  
S Ciesek ◽  
B P. Ringe ◽  
C P. Strassburg ◽  
J Klempnauer ◽  
M P. Manns ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Human Dendritic Cell ◽  
Dendritic Cell Subsets

scholarly journals BLC (CXCL13) is expressed by different dendritic cell subsets in vitro and in vivo

2001 ◽  
Vol 31 (5) ◽  
pp. 1544-1549 ◽  
Author(s):  
Joost L. M. Vissers ◽  
Franca C. Hartgers ◽  
Ernst Lindhout ◽  
Carl G. Figdor ◽  
Gosse J. Adema
Keyword(s):  
Dendritic Cell ◽  
Dendritic Cell Subsets

scholarly journals In vivo and in vitro analyses of α-galactosylceramide uptake by conventional dendritic cell subsets using its fluorescence-labeled derivative

2015 ◽  
Vol 168 (2) ◽  
pp. 300-305 ◽  
Author(s):  
Maki Ushida ◽  
Tomonori Iyoda ◽  
Mitsuhiro Kanamori ◽  
Hiroshi Watarai ◽  
Kazuhiko Takahara ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Dendritic Cell Subsets

The JAK-inhibitor ruxolitinib impairs dendritic cell function in vitro and in vivo

Blood ◽  
2013 ◽  
Vol 122 (7) ◽  
pp. 1192-1202 ◽  
Author(s):  
Annkristin Heine ◽  
Stefanie Andrea Erika Held ◽  
Solveig Nora Daecke ◽  
Stephanie Wallner ◽  
Sowmya Parampalli Yajnanarayana ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cell Function ◽  
Jak Inhibitor ◽  
Dendritic Cell Differentiation ◽  
Key Points ◽  
And Function

Key PointsThe JAK-inhibitor ruxolitinib affects dendritic cell differentiation, phenotype, and function leading to impaired T-cell activation.

scholarly journals Grafts Derived from an α-Synuclein Triplication Patient Mediate Functional Recovery but Develop Disease-Associated Pathology in the 6-OHDA Model of Parkinson’s Disease

2020 ◽  
pp. 1-14
Author(s):  
Shelby Shrigley ◽  
Fredrik Nilsson ◽  
Bengt Mattsson ◽  
Alessandro Fiorenzano ◽  
Janitha Mudannayake ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Lines ◽  
Functional Recovery ◽  
Embryonic Stem ◽  
Hesc Line ◽  
Alternative Source ◽  
And Function

Background: Human induced pluripotent stem cells (hiPSCs) have been proposed as an alternative source for cell replacement therapy for Parkinson’s disease (PD) and they provide the option of using the patient’s own cells. A few studies have investigated transplantation of patient-derived dopaminergic (DA) neurons in preclinical models; however, little is known about the long-term integrity and function of grafts derived from patients with PD. Objective: To assess the viability and function of DA neuron grafts derived from a patient hiPSC line with an α-synuclein gene triplication (AST18), using a clinical grade human embryonic stem cell (hESC) line (RC17) as a reference control. Methods: Cells were differentiated into ventral mesencephalic (VM)-patterned DA progenitors using an established GMP protocol. The progenitors were then either terminally differentiated to mature DA neurons in vitro or transplanted into 6-hydroxydopamine (6-OHDA) lesioned rats and their survival, maturation, function, and propensity to develop α-synuclein related pathology, were assessed in vivo. Results: Both cell lines generated functional neurons with DA properties in vitro. AST18-derived VM progenitor cells survived transplantation and matured into neuron-rich grafts similar to the RC17 cells. After 24 weeks, both cell lines produced DA-rich grafts that mediated full functional recovery; however, pathological changes were only observed in grafts derived from the α-synuclein triplication patient line. Conclusion: This data shows proof-of-principle for survival and functional recovery with familial PD patient-derived cells in the 6-OHDA model of PD. However, signs of slowly developing pathology warrants further investigation before use of autologous grafts in patients.

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