Is acid sensing ion channel 1a a viable therapeutic target for spinal cord injury?

2021 ◽  
Author(s):  
◽  
Victoria Sophie Foster
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Ion Channel ◽  
Therapeutic Target ◽  
Cord Injury

scholarly journals Complement Plays an Important Role in Spinal Cord Injury and Represents a Therapeutic Target for Improving Recovery following Trauma

2006 ◽  
Vol 169 (3) ◽  
pp. 1039-1047 ◽  
Author(s):  
Fei Qiao ◽  
Carl Atkinson ◽  
Hongbin Song ◽  
Ravinder Pannu ◽  
Inderjit Singh ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Therapeutic Target ◽  
Cord Injury

scholarly journals Cytosolic phospholipase A 2 protein as a novel therapeutic target for spinal cord injury

2014 ◽  
Vol 75 (5) ◽  
pp. 644-658 ◽  
Author(s):  
Nai‐Kui Liu ◽  
Ling‐Xiao Deng ◽  
Yi Ping Zhang ◽  
Qing‐Bo Lu ◽  
Xiao‐Fei Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Therapeutic Target ◽  
Phospholipase A ◽  
Cytosolic Phospholipase ◽  
Cord Injury ◽  
Novel Therapeutic ◽  
Phospholipase A 2

scholarly journals Stem Cells in Spinal Cord Injury

2008 ◽  
Vol 24 (4-5) ◽  
pp. 239-250 ◽  
Author(s):  
Jean R. Wrathall ◽  
Judith M. Lytle
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Therapeutic Target ◽  
Proliferative Response ◽  
Traumatic Injury ◽  
Functional Deficits ◽  
Cord Injury ◽  
Adult Spinal Cord

Traumatic injury to the adult spinal cord results in a massive loss of cells and permanent functional deficits. However, recent studies demonstrate that there is a proliferative response of endogenous glial precursors and progenitors and perhaps also pluripotent neural stem cells. These cells may prove to be an important new therapeutic target to improve recovery after injury to the spinal cord and brain.

scholarly journals Effects of chronic spinal cord injury on relationships among ion channel and receptor mRNAs in mouse lumbar spinal cord

2018 ◽  
Author(s):  
Virginia B. Garcia ◽  
Matthew D. Abbinanti ◽  
Ronald M. Harris-Warrick ◽  
David J. Schulz
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Ion Channel ◽  
Motor Neurons ◽  
Receptor Expression ◽  
Lumbar Spinal Cord ◽  
Mrna Levels ◽  
Absolute Quantitation ◽  
Cord Injury ◽  
Lumbar Spinal

ABSTRACTSpinal cord injury (SCI) causes widespread changes in gene expression of the spinal cord, even in the undamaged spinal cord below the level of the lesion. Less is known about changes in the correlated expression of genes after SCI. We investigated gene co-expression networks among voltage-gated ion channel and neurotransmitter receptor mRNA levels using quantitative RT-PCR in longitudinal slices of the mouse lumbar spinal cord in control and chronic SCI animals. These longitudinal slices were made from the ventral surface of the cord, thus forming slices relatively enriched in motor neurons or interneurons. We performed absolute quantitation of mRNA copy number for 50 ion channel or receptor transcripts from each sample, and used multiple correlation analyses to detect patterns in correlated mRNA levels across all pairs of genes. The majority of channels and receptors changed in expression as a result of chronic SCI, but did so differently across slice levels. Furthermore, motor neuron enriched slices experienced an overall loss of correlated channel and receptor expression, while interneuron slices showed a dramatic increase in the number of positively correlated transcripts. These correlation profiles suggest that spinal cord injury induces distinct changes across cell types in the organization of gene co-expression networks for ion channels and transmitter receptors.

scholarly journals TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress

Theranostics ◽  
2020 ◽  
Vol 10 (20) ◽  
pp. 9280-9302
Author(s):  
Kailiang Zhou ◽  
Zhilong Zheng ◽  
Yao Li ◽  
Wen Han ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Er Stress ◽  
Therapeutic Target ◽  
Autophagy Flux ◽  
Potential Therapeutic Target ◽  
Cord Injury

Matrix Metalloproteinases as a Therapeutic Target to Improve Neurologic Recovery After Spinal Cord Injury

2015 ◽  
Author(s):  
Linda J. Noble ◽  
Alpa Mahuvakar ◽  
Thomas Fandel ◽  
Aida F. Martinez ◽  
Jon Levine
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Matrix Metalloproteinases ◽  
Therapeutic Target ◽  
Neurologic Recovery ◽  
Cord Injury
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