Additive manufacturing of biodegradable porous PHBV/Nano-cellulose polymer scaffolds for bone tissue engineering

2020 ◽  
Author(s):  
◽  
Yizhi Bi
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Polymer Scaffolds ◽  
Nano Cellulose

scholarly journals Reconstruction of Bone Defect Based on the Fusion of Osteoblasts and MSM/HA/PLGA Porous Scaffolds

2020 ◽  
Author(s):  
weiling huo ◽  
Xiaodong Wu ◽  
Yancheng zheng ◽  
Jian Cheng ◽  
Qiang Xu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Defect ◽  
Drug Loading ◽  
Release Time ◽  
Porous Scaffolds ◽  
Polymer Scaffolds ◽  
Experimental Basis

Reconstruction of bone defect is one of the difficult problems in orthopedic treatment, and bone tissue scaffold implantation is the most promising direction of bone defect reconstruction. In this study, we used the combination of HA (Hydroxyapatite) and PLGA [Poly (lactic-co-glycolic acid)] in the construction of polymer scaffolds, and introduced bioactive MSM (Methyl sulfonyl methane) into polymer scaffolds to prepare porous scaffolds. The osteoblasts, isolated and cultured in vitro, were seeded in the porous scaffolds to construct tissue-engineered scaffolds. Meanwhile, the model of rabbit radius defect was constructed to evaluate the biological aspects of five tissue-engineered scaffolds, which provided experimental basis for the application of the porous scaffolds in bone tissue engineering. The SEM characterization showed the pore size of porous scaffolds was uniform and the porosity was about 90%. The results of contact Angle testing suggested that the hydrophobic porous scaffold surface could effectively promote cell adhesion and cell proliferation, while mechanical property test showed good machinability. The results of drug loading and release efficiency of MSM showed that porous scaffolds could load MSM efficiently and prolong the release time of MSM. In vitro incubation of porous scaffolds and osteoblasts showed that the addition of a small quantity of MSM could promote the infiltration and proliferation of osteoblasts on the porous scaffolds. Similar results were obtained by implanting the tissue-engineered scaffolds, fused with the osteoblasts and MSM/HA/PLGA porous scaffolds, into the rabbit radius defect, which provided experimental basis for the application of the MSM/HA/PLGA porous scaffolds in bone tissue engineering.

Additive manufacturing of natural biopolymers and composites for bone tissue engineering

2020 ◽  
Vol 7 (8) ◽  
pp. 2011-2027 ◽  
Author(s):  
Susmita Bose ◽  
Caitlin Koski ◽  
Ashley A. Vu
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Defects ◽  
Biomedical Devices ◽  
Significant Progress ◽  
Load Bearing ◽  
Low Load ◽  
Made In

Through additive manufacturing (AM) of natural biopolymers, significant progress has been made in the field of biomedical devices and bone tissue engineering of low load bearing applications like maxillofacial, bone defects, and dental.

Additive manufacturing of wet-spun polymeric scaffolds for bone tissue engineering

2012 ◽  
Vol 14 (6) ◽  
pp. 1115-1127 ◽  
Author(s):  
Dario Puppi ◽  
Carlos Mota ◽  
Matteo Gazzarri ◽  
Dinuccio Dinucci ◽  
Antonio Gloria ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Polymeric Scaffolds
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