scholarly journals Fabrication of HA/PLLA Composite Scaffolds for Bone Tissue Engineering Using Additive Manufacturing Technologies

Biopolymers ◽  
10.5772/10264 ◽  
2010 ◽  
Author(s):  
Fernando Cruz
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Scaffolds ◽  
Manufacturing Technologies

scholarly journals Additive manufacturing of biomorphic scaffolds for bone tissue engineering

2021 ◽  
Vol 113 (9-10) ◽  
pp. 2909-2923
Author(s):  
Fabrizia Caiazzo ◽  
Vittorio Alfieri ◽  
Brahim David Bujazha
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Structural Response ◽  
Powder Bed ◽  
Chemical Catalysis ◽  
Potential Applications ◽  
Manufacturing Technologies ◽  
The Individual

AbstractBone tissue engineering has evolved owing to new opportunities of deep customisation offered by additive manufacturing technologies. Gyroid structures, which have been widely used for energy absorption or chemical catalysis, are now being employed as biomorphic structures as well to provide customer-oriented scaffolds for missing or injured bones. Unfortunately, limited data in terms of manufacturability and mechanical properties are available in the literature to support a wide application scope, because the bone to match is strongly dependent on the individual. Therefore, the study aimed at addressing this lack of knowledge, assessing the manufacturability of metal gyroids and further developing the correlation of the structural response with the designed geometry, so to allow the designer to provide the proper biomorphic structure on a case-by-case basis. Biocompatible steel was used to manufacture samples via laser powder-bed fusion; their elastic moduli and yield strengths were evaluated as a function of the orientation of the elementary cells, the symmetry and the wall thickness based on compression testing. Grounds have been given to support potential applications for tibias and vertebras.

scholarly journals Three-dimensionally printed polycaprolactone/multicomponent bioactive glass scaffolds for potential application in bone tissue engineering

2020 ◽  
Vol 6 (1) ◽  
pp. 57-69
Author(s):  
Amirhosein Fathi ◽  
Farzad Kermani ◽  
Aliasghar Behnamghader ◽  
Sara Banijamali ◽  
Masoud Mozafari ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Three Dimensional ◽  
Layer By Layer ◽  
Composite Scaffolds ◽  
3D Printed ◽  
Co Doped

AbstractOver the last years, three-dimensional (3D) printing has been successfully applied to produce suitable substitutes for treating bone defects. In this work, 3D printed composite scaffolds of polycaprolactone (PCL) and strontium (Sr)- and cobalt (Co)-doped multi-component melt-derived bioactive glasses (BGs) were prepared for bone tissue engineering strategies. For this purpose, 30% of as-prepared BG particles (size <38 μm) were incorporated into PCL, and then the obtained composite mix was introduced into a 3D printing machine to fabricate layer-by-layer porous structures with the size of 12 × 12 × 2 mm3.The scaffolds were fully characterized through a series of physico-chemical and biological assays. Adding the BGs to PCL led to an improvement in the compressive strength of the fabricated scaffolds and increased their hydrophilicity. Furthermore, the PCL/BG scaffolds showed apatite-forming ability (i.e., bioactivity behavior) after being immersed in simulated body fluid (SBF). The in vitro cellular examinations revealed the cytocompatibility of the scaffolds and confirmed them as suitable substrates for the adhesion and proliferation of MG-63 osteosarcoma cells. In conclusion, 3D printed composite scaffolds made of PCL and Sr- and Co-doped BGs might be potentially-beneficial bone replacements, and the achieved results motivate further research on these materials.

Preparation and characterization of nano-sized hydroxyapatite/alginate/chitosan composite scaffolds for bone tissue engineering

2015 ◽  
Vol 54 ◽  
pp. 20-25 ◽  
Author(s):  
Hye-Lee Kim ◽  
Gil-Yong Jung ◽  
Jun-Ho Yoon ◽  
Jung-Suk Han ◽  
Yoon-Jeong Park ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Scaffolds ◽  
Chitosan Composite
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