scholarly journals ROLE OF URINARY ALBUMIN TO CREATININE RATIO AND SPOT ALBUMINURIA IN PREDICTING SIGNIFICANT ALBUMINURIA IN PATIENTS OF DIABETIC NEPHROPATHY

2014 ◽  
Vol 3 (01) ◽  
pp. 38-45
Author(s):  
Gitanjali Gitanjali ◽  
Sudeep Goyal ◽  
KMDS Panag
Keyword(s):  
Diabetic Nephropathy ◽  
Urinary Albumin ◽  
Creatinine Ratio

scholarly journals Gender Differences in Genetic Associations of RAB38 with Urinary Protein-to-Creatinine Ratio (UPCR) Levels in Diabetic Nephropathy Patients

2020 ◽  
Vol 10 (4) ◽  
pp. 184
Author(s):  
Zhi-Lei Yu ◽  
Chung-Shun Wong ◽  
Yi Ting Lai ◽  
Wan-Hsuan Chou ◽  
Imaniar Noor Faridah ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Meta Analysis ◽  
Urinary Albumin ◽  
Urinary Protein ◽  
Creatinine Ratio ◽  
Genetic Associations ◽  
Male Population ◽  
Patients With Diabetes ◽  
European Populations

Renal dysfunction is common in patients with diabetes mellitus (DM). Previous findings from a meta-analysis of GWAS indicated that the variation of RAB38/CTSC is highly associated with the urinary albumin-to-creatinine ratio (UACR) in European populations. In addition, RAB38 knockout rats showed an increase in urinary albumins. Although the prevalence of chronic kidney disease is high in Taiwan, the role of genetic variants in diabetic renal function is still unclear. In the current study, 275 diabetic nephropathy (DN) patients were recruited to perform a genetic association study. Our results indicated that rs1027027, rs302647, and rs302646 in RAB38 were significantly associated with urinary protein-to-creatinine ratio (UPCR) levels in DN patients. Importantly, after analysis stratified by gender, a significant genetic influence on UPCR levels was observed in the male population. The findings confirmed the roles of gender and variants of RAB38 in the risk of UPCR in Diabetic Nephropathy patients.

scholarly journals Comparison of Clinical Trajectories before Initiation of Renal Replacement Therapy between Diabetic Nephropathy and Nephrosclerosis on the KDIGO Guidelines Heat Map

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Masanori Abe ◽  
Kazuyoshi Okada ◽  
Noriaki Maruyama ◽  
Hiroyuki Takashima ◽  
Osamu Oikawa ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Clinical Characteristics ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Urinary Albumin ◽  
Creatinine Ratio ◽  
Single Center ◽  
Heat Map ◽  
Kdigo Guidelines ◽  
Rate Of Decline

This study investigated differences between the clinical trajectories of diabetic nephropathy and nephrosclerosis using the Kidney Disease: Improving Global Outcomes (KDIGO) heat map and the clinical characteristics between the two diseases at RRT initiation. This single-center, retrospective study enrolled 100 patients whose estimated glomerular filtration rate (eGFR) was ≥45 mL/min/1.73 m2at their first visit and who were initiated on RRT. Fifty consecutive patients were assigned to each of the diabetic nephropathy and nephrosclerosis groups. All data for simultaneously measured eGFR and urinary albumin to creatinine ratio (UACR) were collected from first visit to RRT initiation and were plotted on the KDIGO heat map. Diabetic nephropathy was characterized by higher blood pressure and UACR and lower age, eGFR, and serum albumin levels compared with nephrosclerosis at RRT initiation. The vast majority of patients with diabetic nephropathy and eGFR < 60 mL/min/1.73 m2had concomitant macroalbuminuria, whereas for patients with nephrosclerosis, even when eGFR was <45 mL/min/1.73 m2, many still had normoalbuminuria or microalbuminuria. The rate of decline of eGFR was significantly faster in the diabetic nephropathy group than that in the nephrosclerosis group. The clinical trajectories of diabetic nephropathy and nephrosclerosis differed markedly on the KDIGO heat map.

scholarly journals The role of urinary albumin-to-creatinine ratio as a biomarker to predict stroke: A meta-analysis and systemic review

2021 ◽  
Vol 7 (3) ◽  
pp. 139
Author(s):  
Ran Meng ◽  
Min Li ◽  
Aichun Cheng ◽  
Jingkun Sun ◽  
Chunqiu Fan
Keyword(s):  
Meta Analysis ◽  
Urinary Albumin ◽  
Systemic Review ◽  
Creatinine Ratio

MO250URINARY DICKKOPF-3 (UDKK3): A NEW BIOMARKER FOR LONG-TERM CKD PROGRESSION AND MORTALITY?*

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Beatriz Sanchez Alamo ◽  
Francisco Jose Garcia Iñigo ◽  
Amir Shabaka ◽  
Juan Manuel Acedo ◽  
Clara Maria Cases Corona ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Kidney Disease ◽  
Renal Fibrosis ◽  
Primary Outcome ◽  
Creatinine Ratio ◽  
Ckd Progression ◽  
Kidney Disease Progression ◽  
Renal Progression

Abstract Background and Aims Kidney fibrosis has been reported to be a key progression hallmark of chronic kidney disease (CKD). It seems likely that a precise biomarker of renal fibrosis extension would contribute to predict accurately the risk of a decline in glomerular filtration rate (eGFR). Previous studies have shown that the assessment of urinary Dickkopf-3 (uDKK3), a stress induced tubular epithelial-derived profibrotic glycoprotein, might be a potential tubulointerstitial fibrosis biomarker and might identify patients at short-term risk of eGFR loss. We aim to evaluate uDKK3 as a potential biomarker for long-term CKD progression in a cohort with various etiologies of CKD, and subsequently in an overt diabetic nephropathy cohort. We also tested the role of treatment with RAAS blockers on the uDKK3 levels and if the treatment could modify them. Method We prospectively studied two independent cohorts consisted of 356 patients with stage 2-3 CKD. Progreser cohort comprised 255 patients with heterogeneous etiologies of CKD and Pronedi cohort 101 patients with overt diabetic nephropathy. The primary outcome was the time to the first event of the composite endpoint (&gt;50% increase in serum creatinine concentration, end-stage kidney disease [ESKD], or death). We divided patients into tertiles according to their baseline uDKK3 levels: less than 1092 pg/mg (Tertile 1, T1), between 1092-5050 pg/mg (Tertile 2, T2) and higher than 5050 pg/mg (Tertile 3, T3). We used the cut point of T3 as an exploratory cut-off. Cox regression models were used to adjust for potential effects of confounders or modifiers: age, gender, mean arterial pressure, body mass index (BMI), urine albumin/creatinine ratio, urine protein/creatinine ratio and serum creatinine. Mixed-effects models were adjusted to study longitudinal data. Results Progreser cohort and Pronedi cohort did not differ in their clinical baseline characteristics except in proteinuria. At baseline, uDKK3 levels were not different between different etiologies or both cohorts, median uDKK3 was 2199 (IQR: 658-7618) pg/mg in the Progreser cohort and 3041 (IQR: 653-9777) pg/mg in the Pronedi cohort (p:0.56). Median time of follow-up was 36 months. Forty-nine patients (19 %) in Progreser cohort and 31 patients (31%) in Pronedi cohort reached the primary composite outcome. Baseline uDKK3 was significantly higher in patients who reached primary outcome. In Cox multivariate model, after adjustment for potential confounders, the highest levels of uDKK3 were found to be an independent factor for renal progression in Progreser cohort (HR 1.83, CI95% 1.11-3.31) and in Pronedi cohort (HR 2.74, CI95% 1.09-6.98). Both in the Progreser and the Pronedi cohorts, uDKK3 levels above 5050 pg/mg, were associated with a lower eGFR, higher proteinuria and were independently associated with a worse renal survival. uDKK3 gradually increased in the following months, especially in patients with higher proteinuria. Treatment with RAAS-blockers did not modify uDKK3 after 4 or 12 months of treatment. Conclusion In this study, uDKK3 ratio identified patients at high risk for long-term kidney disease progression regardless of the etiology of CKD. The hypothesis was generated in a cohort of patients with CKD of heterogeneous etiologies and was further confirmed in a cohort with overt diabetic nephropathy. The predictive role of uDKK3 persisted after adjusting by eGFR and proteinuria. uDKK3 is the first non-invasive biomarker of renal fibrosis and might serve as a useful biomarker for kidney disease progression. Therefore uDKK3 could be used by clinicians to optimize staging for renal progression and monitor therapeutic efficacy of different measures to halt CKD progression.

Screening for diabetic nephropathy: is measurement of urinary albumin-to-creatinine ratio worthwhile?

Diabetes Care ◽  
1999 ◽  
Vol 22 (9) ◽  
pp. 1599-1600 ◽  
Author(s):  
J. L. Gross ◽  
T. Zelmanovitz ◽  
J. Oliveira ◽  
M. J. de Azevedo
Keyword(s):  
Diabetic Nephropathy ◽  
Urinary Albumin ◽  
Creatinine Ratio

scholarly journals The Effect of Chinese Herbal Medicine on Albuminuria Levels in Patients with Diabetic Nephropathy: A Systematic Review and Meta-Analysis

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Ya Xiao ◽  
Yanyan Liu ◽  
Keqiang Yu ◽  
Lin Zhou ◽  
Jianlu Bi ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Large Scale ◽  
Angiotensin Receptor Blockers ◽  
Urinary Albumin ◽  
Cochrane Library ◽  
Creatinine Ratio ◽  
Serious Adverse Events ◽  
Chinese Herbal

To evaluate the effect of Chinese herbal medicine (CHM) on albuminuria levels in patients with diabetic nephropathy (DN), we performed comprehensive searches on Medline database, Cochrane Library, CNKI database, CBM database, Wanfang database, and VIP database up to December 2012. A total of 29 trials including 2440 participants with DN met the selection criteria. CHM was tested to be more effective in reducing urinary albumin excretion rate (UAER) (MD −82.95 μg/min, [−138.64, −27.26]) and proteinuria (MD −565.99 mg/24 h, [−892.41, −239.57]) compared with placebo. CHM had a greater beneficial effect on reduction of UAER (MD −13.41 μg/min, [−20.63, −6.19]) and proteinuria (MD −87.48 mg/24 h, [−142.90, −32.06]) compared with angiotensin converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB). Combination therapy with CHM and ACEI/ARB showed significant improvement in UAER (MD −28.18 μg/min, [−44.4, −11.97]), urinary albumin-creatinine ratio (MD −347.00, [−410.61, −283.39]), protein-creatinine ratio (MD −2.49, [−4.02, −0.96]), and proteinuria (MD −26.60 mg/24 h, [−26.73, −26.47]) compared with ACEI/ARB alone. No serious adverse events were reported. CHM seems to be an effective and safe therapy option to treat proteinuric patients with DN, suggesting that further study of CHM in the treatment of DN is warranted in rigorously designed, multicentre, large-scale trials with higher quality worldwide.

Correlation of blood uric acid with urinary albumin creatinine ratio in hypertension and diabetic nephropathy

2016 ◽  
Vol 13 (1) ◽  
pp. 24-30
Author(s):  
K.N. Shashidhar ◽  
U. Munilakshmi ◽  
K. Prabhavathi ◽  
Madhavi Reddy ◽  
V. Lakshmaiah
Keyword(s):  
Uric Acid ◽  
Diabetic Nephropathy ◽  
Urinary Albumin ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio ◽  
Blood Uric Acid

scholarly journals Correlation between serum carnosinase concentration and renal damage in diabetic nephropathy patients

Amino Acids ◽  
2021 ◽  
Author(s):  
Zhou Zhou ◽  
Xue-qi Liu ◽  
Shi-qi Zhang ◽  
Xiang-ming Qi ◽  
Qiu Zhang ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Tissue Injury ◽  
Albumin Excretion Rate ◽  
Underlying Mechanism ◽  
Urinary Albumin ◽  
Urinary Protein ◽  
Retinol Binding Protein ◽  
Creatinine Ratio ◽  
Predisposing Factor ◽  
The Relationship

AbstractDiabetic nephropathy (DN) is one of the major complications of diabetes and contributes significantly towards end-stage renal disease. Previous studies have identified the gene encoding carnosinase (CN-1) as a predisposing factor for DN. Despite this fact, the relationship of the level of serum CN-1 and the progression of DN remains uninvestigated. Thus, the proposed study focused on clarifying the relationship among serum CN-1, indicators of renal function and tissue injury, and the progression of DN. A total of 14 patients with minimal changes disease (MCD) and 37 patients with DN were enrolled in the study. Additionally, 20 healthy volunteers were recruited as control. Further, DN patients were classified according to urinary albumin excretion rate into two groups: DN with microalbuminuria (n = 11) and DN with macroalbuminuria (n = 26). Clinical indicators including urinary protein components, serum carnosine concentration, serum CN-1 concentration and activity, and renal biopsy tissue injury indexes were included for analyzation. The serum CN-1 concentration and activity were observed to be the highest, but the serum carnosine concentration was the lowest in DN macroalbuminuria group. Moreover, within DN group, the concentration of serum CN-1 was positively correlated with uric acid (UA, r = 0.376, p = 0.026) and serum creatinine (SCr, r = 0.399, p = 0.018) and negatively correlated with serum albumin (Alb, r = − 0.348, p = 0.041) and estimated glomerular filtration rate (eGRF, r = − 0.432, p = 0.010). Furthermore, the concentration of serum CN-1 was discovered to be positively correlated with indicators including 24-h urinary protein–creatinine ratio (24 h-U-PRO/CRE, r = 0.528, p = 0.001), urinary albumin-to-creatinine ratio (Alb/CRE, r = 0.671, p = 0.000), urinary transferrin (TRF, r = 0.658, p = 0.000), retinol-binding protein (RBP, r = 0.523, p = 0.001), N-acetyl-glycosaminidase (NAG, r = 0.381, p = 0.024), immunoglobulin G (IgG, r = 0.522, p = 0.001), cystatin C (Cys-C, r = 0.539, p = 0.001), beta-2-microglobulin (β2-MG, r = 0.437, p = 0.009), and alpha-1-macroglobulin (α1-MG, r = 0.480, p = 0.004). Besides, in DN with macroalbuminuria group, serum CN-1 also showed a positive correlation with indicators of fibrosis, oxidative stress, and renal tubular injury. Taken together, our data suggested that the level of CN-1 was increased as clinical DN progressed. Thus, the level of serum CN-1 might be an important character during the occurrence and progression of DN. Our study will contribute significantly to future studies focused on dissecting the underlying mechanism of DN.

Relationship Between Atrasentan Concentrations and Urinary Albumin to Creatinine Ratio in Western and Japanese Patients With Diabetic Nephropathy

2018 ◽  
Vol 40 (2) ◽  
pp. 242-251 ◽  
Author(s):  
Chih-Wei Lin ◽  
Nael M. Mostafa ◽  
Dennis L. Andress ◽  
John J. Brennan ◽  
Cheri E. Klein ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Japanese Patients ◽  
Urinary Albumin ◽  
Creatinine Ratio
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