scholarly journals The role of urinary albumin-to-creatinine ratio as a biomarker to predict stroke: A meta-analysis and systemic review

2021 ◽  
Vol 7 (3) ◽  
pp. 139
Author(s):  
Ran Meng ◽  
Min Li ◽  
Aichun Cheng ◽  
Jingkun Sun ◽  
Chunqiu Fan
Keyword(s):  
Meta Analysis ◽  
Urinary Albumin ◽  
Systemic Review ◽  
Creatinine Ratio

scholarly journals Gender Differences in Genetic Associations of RAB38 with Urinary Protein-to-Creatinine Ratio (UPCR) Levels in Diabetic Nephropathy Patients

2020 ◽  
Vol 10 (4) ◽  
pp. 184
Author(s):  
Zhi-Lei Yu ◽  
Chung-Shun Wong ◽  
Yi Ting Lai ◽  
Wan-Hsuan Chou ◽  
Imaniar Noor Faridah ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Meta Analysis ◽  
Urinary Albumin ◽  
Urinary Protein ◽  
Creatinine Ratio ◽  
Genetic Associations ◽  
Male Population ◽  
Patients With Diabetes ◽  
European Populations

Renal dysfunction is common in patients with diabetes mellitus (DM). Previous findings from a meta-analysis of GWAS indicated that the variation of RAB38/CTSC is highly associated with the urinary albumin-to-creatinine ratio (UACR) in European populations. In addition, RAB38 knockout rats showed an increase in urinary albumins. Although the prevalence of chronic kidney disease is high in Taiwan, the role of genetic variants in diabetic renal function is still unclear. In the current study, 275 diabetic nephropathy (DN) patients were recruited to perform a genetic association study. Our results indicated that rs1027027, rs302647, and rs302646 in RAB38 were significantly associated with urinary protein-to-creatinine ratio (UPCR) levels in DN patients. Importantly, after analysis stratified by gender, a significant genetic influence on UPCR levels was observed in the male population. The findings confirmed the roles of gender and variants of RAB38 in the risk of UPCR in Diabetic Nephropathy patients.

The Potential Role of Arginine Supplements on Erectile Dysfunction: A Systemic Review and Meta-Analysis

2019 ◽  
Vol 16 (2) ◽  
pp. 223-234 ◽  
Author(s):  
Hye Chang Rhim ◽  
Min Seo Kim ◽  
Young-Jin Park ◽  
Woo Suk Choi ◽  
Hyoung Keun Park ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Potential Role ◽  
Meta Analysis ◽  
Systemic Review

scholarly journals S0397 Role of Endoscopic Vacuum Therapy in the Management of Esophageal Anastomotic Leak: A Systemic Review and Meta-Analysis

2020 ◽  
Vol 115 (1) ◽  
pp. S197-S197
Author(s):  
Faris Hammad ◽  
Yazan Fahmawi ◽  
Yousef Abdel-Aziz ◽  
Sami Ghazaleh ◽  
Haneen Abdalhadi ◽  
...  
Keyword(s):  
Anastomotic Leak ◽  
Meta Analysis ◽  
Systemic Review ◽  
Vacuum Therapy ◽  
Endoscopic Vacuum Therapy

scholarly journals Role of thoracic radiotherapy in extensive stage small cell lung cancer: a systemic review and meta-analysis

2021 ◽  
Vol 9 (4) ◽  
pp. 299-299
Author(s):  
Ao-Mei Li ◽  
Han Zhou ◽  
Yang-Yang Xu ◽  
Xiao-Qin Ji ◽  
Tian-Cong Wu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Meta Analysis ◽  
Small Cell ◽  
Systemic Review ◽  
Thoracic Radiotherapy ◽  
Small Cell Lung ◽  
Extensive Stage

Abstract 221: Prognostic Role of elevated Myeloperoxidase in Patients with Acute Coronary Syndrome: A Systemic Review and Meta-Analysis.

2014 ◽  
Vol 115 (suppl_1) ◽  
Author(s):  
Andrew R Kolodziej ◽  
Charles L Campbell ◽  
Richard Charnigo ◽  
Raphael Twerenbold ◽  
Christian Mueller ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Meta Analysis ◽  
Systemic Review ◽  
Major Adverse Cardiovascular Events ◽  
Poor Prognostic Factor ◽  
Coronary Syndrome ◽  
Prospective Trials ◽  
Long Term Prognosis

BACKGROUND: It has been shown that Myeloperoxidase (MPO) is intimately involved in pathogenesis of atherosclerosis and Acute Coronary Syndrome (ACS). Small studies have shown that high levels of MPO are a poor prognostic factor in patients presenting with ACS. However, due to the small nature of these studies, the relationship between MPO and outcomes has not been confirmed. Here we aimed to examine the prognostic value of MPO in patients with ACS. METHODS: We performed a meta-analysis to compare the long-term prognosis of ACS patients with high MPO and low MPO levels. The literature was retrieved by formal searches of electronic databases (PubMed, EMBASE, Medline, OVID, and web of knowledge) from inception to November 2013. A total of 16 trials were included in this meta-analysis involving 10572 patients. Data were analyzed using random-effects model and study quality was assessed using appropriate scales. RESULTS: High MPO group was associated with overall worse outcomes than low MPO group in terms of recurrent myocardial infarction (9% [211 of 2336] vs. 7.7% [240 of 3101], odds ratio [OR] 1.4, 95% confidence interval [CI]: 0.92-2.15, p 0.11); all cause mortality (8% [236 of 2920] vs. 5% [209 of 4263], OR 1.83, 95% CI: 1.31-2.54, p <0.0004) and Major Adverse Cardiovascular Events (MACE) (24% [334 of 1400] vs. 14% [133 of 949], OR 2.04, 95% CI: 1.46-2.85, p< 0.0001) (Figure). CONCLUSIONS: In this meta-analysis examining the long-term outcomes in ACS patients, high MPO levels were associated with worse outcomes. These observations support prospective trials tailoring more aggressive therapy to patients with suspected worse prognosis.

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