scholarly journals Report of a Case of Signet Ring Carcinoma Presenting as Gastric Mucosal Thickening: A Diagnostic Dilemma

2021 ◽  
Vol 9 (1) ◽  
pp. 120-124
Author(s):  
Cumali KARATOPRAK ◽  
Adem AKÇAKAYA ◽  
Hakan ŞENTÜRK ◽  
Ganime ÇOBAN ◽  
Nurhan ŞAHİN ◽  
...  
Keyword(s):  
Diagnostic Dilemma ◽  
Signet Ring ◽  
Mucosal Thickening ◽  
Signet Ring Carcinoma

Histomorphologic Assessment of Formalin Substitute Fixatives for Diagnostic Surgical Pathology

2005 ◽  
Vol 129 (4) ◽  
pp. 502-506 ◽  
Author(s):  
Michael E. Titford ◽  
Marcelo G. Horenstein
Keyword(s):  
Myxoid Liposarcoma ◽  
The United States ◽  
Surgical Pathology ◽  
Blind Study ◽  
Endometrioid Adenocarcinoma ◽  
Follicular Hyperplasia ◽  
Signet Ring ◽  
Laboratory Workers ◽  
Hematoxylin Eosin ◽  
Signet Ring Carcinoma

Abstract Context.—In 1987, the Formaldehyde Standard became law in the United States, alerting laboratory workers to the potential carcinogenicity of formaldehyde. As a result, a variety of proprietary fixatives were developed for use in surgical pathology. Objective.—To assess histomorphology with different formalin substitute fixatives. Design.—Four experienced board-certified surgical pathologists examined 7 specimens (hepatocellular carcinoma, ovarian sex cord/stromal tumor, myxoid liposarcoma, uterine endometrioid adenocarcinoma, splenic follicular hyperplasia, infiltrating mammary carcinoma, and cecal signet ring carcinoma) fixed with formalin and 5 proprietary fixatives advertised as formalin replacements. In a blind study, the pathologists rated cellular outlines, cytoplasmic detail, nuclear detail, erythrocyte integrity, lymphocyte integrity, overall morphology, and overall staining in each case. Results.—Formalin received the highest overall morphology and staining scores, followed by Glyo-Fixx, STF-Streck, Omnifix, Histochoice, and Histofix. Formalin also received the highest scores in cellular outline and erythrocyte integrity. Individually, some fixatives performed better in different areas than others. Glyo-Fixx performed as well as formalin for overall morphology and provided highest nuclear detail and lymphocyte appearance scores. Omnifix II gave best results for cytoplasmic detail. Conclusion.—In this blind study, formalin fixation provided the highest histomorphologic quality for tissue stained with hematoxylin-eosin and examined for diagnostic surgical pathology. Should the use of formalin be discontinued, pathologists will have to familiarize themselves with a different set of microscopic details associated with the replacement fixatives.

Mucinous (Noncystic) Adenocarcinoma, Including Signet-Ring Carcinoma

1994 ◽  
pp. 155-158
Author(s):  
Parviz M. Pour ◽  
Yoichi Konishi ◽  
Günter Klöppel ◽  
Daniel S. Longnecker
Keyword(s):  
Signet Ring ◽  
Signet Ring Carcinoma

scholarly journals Ovarian Mixed Malignant Brenner-Mucinous Tumor with Signet Ring Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Baharak Khadang ◽  
Atilla Omeroglu
Keyword(s):  
Ovarian Carcinoma ◽  
Mucinous Tumor ◽  
Signet Ring Cells ◽  
Brenner Tumor ◽  
Signet Ring ◽  
Signet Ring Carcinoma

Mucinous carcinomas with signet ring cells in the ovary, particularly those composed predominantly of signet ring cells, are extremely rare, and in vast majority of cases, they represent metastasis from another site such as the stomach, appendix, pancreaticobiliary tract, bladder, and breast (Hristov et al., 2007, Kiyokawa et al., 2006, Vang et al., 2006, Young, 2006). Malignant Brenner tumor is also rare comprising less than 0.5% of ovarian carcinoma. Although mixed Brenner-Mucinous tumors are relatively common, the combination of a primary ovarian signet ring carcinoma with a malignant Brenner tumor is unique and to the best of our knowledge not previously reported in the literature.

Primary signet ring carcinoma of the colon and rectum

1995 ◽  
Vol 26 (4) ◽  
pp. 378-379 ◽  
Author(s):  
N.H.H. NADHA SARMA ◽  
L.D. GAHUKAMBLE ◽  
R.N. VISWESWARA ◽  
K. RAMESH ◽  
O. AL FITURI ◽  
...  
Keyword(s):  
Carcinoma Of The Colon ◽  
Signet Ring ◽  
Colon And Rectum ◽  
Signet Ring Carcinoma

Signet-ring cell carcinoma in gastric biopsies: expecting the unexpected

2012 ◽  
Vol 66 (2) ◽  
pp. 136-139 ◽  
Author(s):  
Christopher P Golembeski ◽  
Robert Maximilian Genta
Keyword(s):  
Signet Ring Cell ◽  
Gastric Biopsy ◽  
Intestinal Type ◽  
Ring Type ◽  
Signet Ring ◽  
Ambulatory Patients ◽  
Gastric Biopsies ◽  
Ring Cell ◽  
Primary Gastric Carcinoma ◽  
Signet Ring Carcinoma

AimsThis study was designed to establish the relative prevalence of intestinal-type and signet-ring carcinoma in gastric biopsy specimens from ambulatory patients, to determine the percentage of signet-ring carcinomas that could be expected based on the available clinical and endoscopic information, and to estimate the likelihood of missing a tumour.MethodsWe extracted data of all patients with a diagnosis of primary gastric carcinoma from a national pathology database. We then reviewed clinical information and original slides, classified tumours as intestinal or signet-ring-type, and categorised the latter as ‘unexpected’ (no alarming symptoms, no mention of suspicious lesions) or ‘expected’ (clinical or endoscopic information suggestive of tumour). Unexpected signet-ring carcinomas were categorised as ‘obvious’ or ‘challenging’ (rare signet-ring cells; immunohistochemical stains used to confirm the nature of the infiltrates).ResultsThere were 310 109 patients with gastric biopsies; 615 patients had primary gastric carcinoma (359 intestinal and 256 signet-ring-type). Gastric cancer was more common in men (OR 2.54; 95% CI 2.05 to 3.14; p<.0001) for intestinal-type and (OR 1.90; 95% CI 1.48 to 2.42; p<0.0001) for signet-ring cell type). Intestinal-type carcinoma occurred in older patients than signet-ring-type (median age 74 vs 65 years, p<0.001). There were 196 expected and 60 unexpected signet-ring carcinomas; 47 of the 60 unexpected cases were histopathologically obvious. Thus, only 13 signet-ring carcinomas (1 in 25 000 gastric biopsy sets) were truly unexpected.ConclusionsSignet-ring carcinoma is a rare finding in gastric biopsy specimens from ambulatory patients; routine due diligence and the clinical/endoscopic information provided are usually adequate to raise pathologists’ index of suspicion.

scholarly journals Histopathological spectrum of duodenal biopsies: Experience at a tertiary care hospital

2019 ◽  
Vol 2 (2) ◽  
pp. 58-61
Author(s):  
Zafar Ali ◽  
Ghazala Mudassir ◽  
Imran Nazir ◽  
Nadira Mamoon
Keyword(s):  
Celiac Disease ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Metastatic Adenocarcinoma ◽  
Signet Ring ◽  
Neoplastic Lesions ◽  
Crypt Hyperplasia ◽  
Duodenal Biopsies ◽  
Signet Ring Carcinoma

Objective: Endoscopic duodenal biopsies constitute a significant load of specimens in the histopathological section of a tertiary care hospital. Most of these diseases comprise non-neoplastic lesions causing significant morbidity. The purpose of this study was to see the frequency of these diseases in our patient population and to compare and analyze our results with similar other studies. Methods: In this retrospective study records of all duodenal biopsies reported from Feb 2017- Jan 2018 were retrieved. Both non neoplastic and neoplastic conditions along with biopsies with unremarkable findings were included. Various histological parameters like villous blunting, IEL count per 100 enterocytes, crypt hyperplasia, inflammation in lamina propria, and presence of microorganisms, any dysplasia or malignancy were studied. Data was statistically analyzed using SPSS v.23. Results: A total of 159 duodenal biopsies were included in the study. Normal duodenal morphology was noted in 85 (53.45%) cases while 74 (46.83%) cases revealed abnormal duodenal pathology. There were 46 (28.93%) cases consistent with celiac disease. Twenty eight (17.61%) cases were of other duodenal pathologies of which non-specific duodenitis was most common. There were 22 (13.83%) cases of duodenitis and 2 (1.26%) cases were of duodenal ulcer. One case (0.62%) each was seen of Brunner gland hyperplasia, adenocarcinoma, signet ring carcinoma and one case was of metastatic adenocarcinoma. Conclusion: In our study we found a significant percentage of 46.83% exhibiting abnormal duodenal pathology. Cases consistent with celiac disease were 28.93% while 13.83% of the cases had duodenitis. The percentage of malignant cases was minimal (1.88%).

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