scholarly journals Ovarian Mixed Malignant Brenner-Mucinous Tumor with Signet Ring Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Baharak Khadang ◽  
Atilla Omeroglu
Keyword(s):  
Ovarian Carcinoma ◽  
Mucinous Tumor ◽  
Signet Ring Cells ◽  
Brenner Tumor ◽  
Signet Ring ◽  
Signet Ring Carcinoma

Mucinous carcinomas with signet ring cells in the ovary, particularly those composed predominantly of signet ring cells, are extremely rare, and in vast majority of cases, they represent metastasis from another site such as the stomach, appendix, pancreaticobiliary tract, bladder, and breast (Hristov et al., 2007, Kiyokawa et al., 2006, Vang et al., 2006, Young, 2006). Malignant Brenner tumor is also rare comprising less than 0.5% of ovarian carcinoma. Although mixed Brenner-Mucinous tumors are relatively common, the combination of a primary ovarian signet ring carcinoma with a malignant Brenner tumor is unique and to the best of our knowledge not previously reported in the literature.

scholarly journals A diagnostic dilemma: A rare case of an ovarian carcinoma with signet ring cells hidden behind a substantial dermatomyositis

2019 ◽  
Vol 15 (6) ◽  
pp. 1395
Author(s):  
AsimArmagan Aydin ◽  
Hulya Ayik ◽  
ArifHakan Onder ◽  
Banu Ozturk ◽  
Mustafa Yildiz
Keyword(s):  
Ovarian Carcinoma ◽  
Rare Case ◽  
Diagnostic Dilemma ◽  
Signet Ring Cells ◽  
Signet Ring

Endometrial Adenocarcinoma With Signet Ring Cells

2010 ◽  
Vol 29 (6) ◽  
pp. 579-582 ◽  
Author(s):  
Clinton Boyd ◽  
Iain Cameron ◽  
W. Glenn McCluggage
Keyword(s):  
Endometrial Adenocarcinoma ◽  
Signet Ring Cells ◽  
Signet Ring

Papillary Urothelial Carcinoma of the Urinary Bladder Demonstrating Prominent Signet-Ring Cells in a Smear

1998 ◽  
Vol 42 (2) ◽  
pp. 407-412 ◽  
Author(s):  
Toshihito Shinagawa ◽  
Mamoru Tadokoro ◽  
Mitsubumi Abe ◽  
Yutaka Koshitaka ◽  
Shoujiroh Kouno ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Signet Ring Cells ◽  
Signet Ring ◽  
Papillary Urothelial Carcinoma

Histomorphologic Assessment of Formalin Substitute Fixatives for Diagnostic Surgical Pathology

2005 ◽  
Vol 129 (4) ◽  
pp. 502-506 ◽  
Author(s):  
Michael E. Titford ◽  
Marcelo G. Horenstein
Keyword(s):  
Myxoid Liposarcoma ◽  
The United States ◽  
Surgical Pathology ◽  
Blind Study ◽  
Endometrioid Adenocarcinoma ◽  
Follicular Hyperplasia ◽  
Signet Ring ◽  
Laboratory Workers ◽  
Hematoxylin Eosin ◽  
Signet Ring Carcinoma

Abstract Context.—In 1987, the Formaldehyde Standard became law in the United States, alerting laboratory workers to the potential carcinogenicity of formaldehyde. As a result, a variety of proprietary fixatives were developed for use in surgical pathology. Objective.—To assess histomorphology with different formalin substitute fixatives. Design.—Four experienced board-certified surgical pathologists examined 7 specimens (hepatocellular carcinoma, ovarian sex cord/stromal tumor, myxoid liposarcoma, uterine endometrioid adenocarcinoma, splenic follicular hyperplasia, infiltrating mammary carcinoma, and cecal signet ring carcinoma) fixed with formalin and 5 proprietary fixatives advertised as formalin replacements. In a blind study, the pathologists rated cellular outlines, cytoplasmic detail, nuclear detail, erythrocyte integrity, lymphocyte integrity, overall morphology, and overall staining in each case. Results.—Formalin received the highest overall morphology and staining scores, followed by Glyo-Fixx, STF-Streck, Omnifix, Histochoice, and Histofix. Formalin also received the highest scores in cellular outline and erythrocyte integrity. Individually, some fixatives performed better in different areas than others. Glyo-Fixx performed as well as formalin for overall morphology and provided highest nuclear detail and lymphocyte appearance scores. Omnifix II gave best results for cytoplasmic detail. Conclusion.—In this blind study, formalin fixation provided the highest histomorphologic quality for tissue stained with hematoxylin-eosin and examined for diagnostic surgical pathology. Should the use of formalin be discontinued, pathologists will have to familiarize themselves with a different set of microscopic details associated with the replacement fixatives.

Cytology Detects Endobronchial Metastasis from Appendiceal Signet-Ring Cell Carcinoma in the Absence of Radiographic Lung Masses: A Case Report

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S44-S44
Author(s):  
B W Taylor ◽  
K Hummel ◽  
Y Xu
Keyword(s):  
Case Report ◽  
Respiratory Distress ◽  
Cell Carcinoma ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Signet Ring Cells ◽  
Endobronchial Metastasis ◽  
Signet Ring ◽  
Ring Cell ◽  
The Right

Abstract Introduction/Objective Endobronchial metastasis (EBM) is uncommon, with a reported prevalence of 2% in cases of non-lung primary malignancies. The most frequently observed carcinomas in EBM are from breast, colon, and renal origins. We present a rare case of endobronchial metastasis from a primary tumor of the appendix without lung masses by computed tomography (CT). Methods/Case Report An 83-year-old woman with signet-ring cell carcinoma of the appendix underwent right hemicolectomy and chemotherapy. Two years later, she returned with intractable nausea and vomiting, and respiratory distress. CT of the chest demonstrated diffuse bilateral pulmonary opacities without lung masses. CT of the abdomen showed peritoneal carcinomatosis. Cytology of ascitic fluid displayed metastasis of the patient’s known appendiceal tumor. Bronchoscopy found significant friable debris appearing to be tumor tissue and occluding multiple bronchioles in the right lung. A bronchoalveolar lavage (BAL) specimen from the right lung was sent for liquid-based cytology, which revealed a few atypical cells with eccentric nuclei and intracytoplasmic vacuoles, abundant macrophages, degenerated mixed inflammatory cells, and scattered bronchial epithelial cells. Cell block demonstrated signet-ring cells mimicking macrophages and infiltrating into small fragments of bronchiolar wall. The signet-ring cells were morphologically similar to those found in the ascitic fluid and the patient’s primary tumor, and were highlighted by mucicarmine stain and immunohistochemical stains for CDX-2 and CK20, but not CK7. Results (if a Case Study enter NA) N/A Conclusion Collectively, the findings supported the diagnosis of endobronchial metastasis of signet-ring cell carcinoma from the lower gastrointestinal tract, i.e. the patient’s known appendiceal primary. Our case demonstrates a rare endobronchial metastasis of a primary neoplasm of the appendix, an important diagnostic consideration when evaluating respiratory distress in patients with such cancer histories. We have described the significant role of BAL cytology to uncover endobronchial metastases without lung masses by CT, and illustrated the finding of signet-ring cells mimicking macrophages in a BAL cytology specimen.

scholarly journals Mutations in Epigenetic Regulation Genes in Gastric Cancer

Cancers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 4586
Author(s):  
Marina V. Nemtsova ◽  
Alexey I. Kalinkin ◽  
Ekaterina B. Kuznetsova ◽  
Irina V. Bure ◽  
Ekaterina A. Alekseeva ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Chromatin Remodeling ◽  
Epigenetic Regulation ◽  
Somatic Mutations ◽  
Distant Metastases ◽  
Clinical Markers ◽  
Signet Ring Cells ◽  
Mutational Profiling ◽  
Signet Ring ◽  
Epigenetic Processes

We have performed mutational profiling of 25 genes involved in epigenetic processes on 135 gastric cancer (GC) samples. In total, we identified 79 somatic mutations in 49/135 (36%) samples. The minority (n = 8) of mutations was identified in DNA methylation/demethylation genes, while the majority (n = 41), in histone modifier genes, among which mutations were most commonly found in KMT2D and KMT2C. Somatic mutations in KMT2D, KMT2C, ARID1A and CHD7 were mutually exclusive (p = 0.038). Mutations in ARID1A were associated with distant metastases (p = 0.03). The overall survival of patients in the group with metastases and in the group with tumors with signet ring cells was significantly reduced in the presence of mutations in epigenetic regulation genes (p = 0.036 and p = 0.041, respectively). Separately, somatic mutations in chromatin remodeling genes correlate with low survival rate of patients without distant metastasis (p = 0.045) and in the presence of signet ring cells (p = 0.0014). Our results suggest that mutations in epigenetic regulation genes may be valuable clinical markers and deserve further exploration in independent cohorts.

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