Mucoadhesive polymers in ophthalmic therapy

Mucoadhesive Polymers for Delivery of Drugs to the Oral Cavity

Recent Patents on Drug Delivery & Formulation ◽

10.2174/187221108784534126 ◽

2008 ◽

Vol 2 (2) ◽

pp. 108-119 ◽

Cited By ~ 32

Author(s):

Boaz Mizrahi ◽

Abraham Domb

Keyword(s):

Oral Cavity ◽

Mucoadhesive Polymers

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Development, Characterization and Optimization of Mucoadhesive Tablet for Buccal Delivery of Domperidone

Drug Delivery Letters ◽

10.2174/2210303108666181108120840 ◽

2019 ◽

Vol 9 (1) ◽

pp. 37-49

Author(s):

Jagdale Sachin ◽

Panbude Aishwarya ◽

Navasare Priya

Keyword(s):

Drug Release ◽

Factorial Design ◽

Research Work ◽

Wet Granulation ◽

Buccal Delivery ◽

Scanning Calorimetry ◽

Mucoadhesive Polymers ◽

First Pass Metabolism ◽

First Pass ◽

Pass Metabolism

Background and Objective: Upon oral administration domeperidone is rapidly absorbed, but subjected to the first pass effect which lowers systemic bioavailability to 15%. Mucoadhesive tablet can remain attached to buccal mucosa and becomes capable of bypassing hepatic first-pass metabolism to improve absorption directly into systemic circulation. The present research work was carried with an aim to develop, evaluate and optimize mucoadhesive tablet containing domperidone (DOME) for buccal delivery using different bio-adhesive polymeric combinations. </P><P> Methods: The buccal tablets were formulated by wet granulation method using isopropyl alcohol. The preliminary formulations were prepared using combinations of HPMC K4, HPMC K15, HPMC K100, HPMC E5 as mucoadhesive polymers. 32 full factorial design was applied to determine the effect of independent variables like concentration of mucoadhesive polymers (HPMC K15 and HPMC K100) over dependent variables like mucoadhesive properties (swelling index, bioadhesive strength and in vitro drug release). The prepared mucoadhesive tablets were evaluated for their tablet properties and mucoadhesive properties. The interactions between drug and polymers were studied by Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC). </P><P> Results: All formulations of factorial design showed satisfactory physicochemical, mechanical and bioadhesive characteristics. The formulation F9 exhibited maximum cumulative drug release, mucoadhesive strength and swelling index. Conclusion: The developed buccal tablet of domperidone might prove alternative to bypass the hepatic first pass metabolism and to avoid degradation which in turn may result in reducing the frequency of administration. Thus, mucoadhesive tablet of domeperidone may become viable alternative overcoming the side effects; achieving greater therapeutic effectiveness and improving the patient compliance.

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Mucoadhesive Delivery Systems. I. Evaluation of Mucoadhesive Polymers for Buccal Tablet Formulation

Drug Development and Industrial Pharmacy ◽

10.1081/ddc-200037245 ◽

2004 ◽

Vol 30 (9) ◽

pp. 985-993 ◽

Cited By ~ 76

Author(s):

Noha Adel Nafee ◽

Fatma Ahmed Ismail ◽

Nabila Ahmed Boraie ◽

Lobna Mohamed Mortada

Keyword(s):

Delivery Systems ◽

Tablet Formulation ◽

Mucoadhesive Polymers ◽

Buccal Tablet

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Role of mucoadhesive polymers in retention of toothpaste in the oral cavity

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2021.112104 ◽

2021 ◽

pp. 112104

Author(s):

Sam R. Aspinall ◽

Jane K. Parker ◽

Vitaliy V. Khutoryanskiy

Keyword(s):

Oral Cavity ◽

Mucoadhesive Polymers

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Design and Characterization of Buccoadhesive Liquisolid System of an Antihypertensive Drug

Journal of Drug Delivery ◽

10.1155/2015/574247 ◽

2015 ◽

Vol 2015 ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Nilesh P. Kala ◽

Divyesh H. Shastri ◽

Pragna K. Shelat

Keyword(s):

Ex Vivo ◽

Flow Parameters ◽

Mucoadhesive Polymers ◽

Dissolution Properties ◽

Powder Characteristics ◽

Bioadhesive Polymers ◽

Tablet Formulations ◽

Permeability Studies ◽

Aluminium Silicate

Nifedipine is an antihypertensive BCS class II drug which has poor bioavailability when given orally. The objective of the present study was to increase the bioavailability of nifedipine, by formulation and evaluation of a buccoadhesive liquisolid system using magnesium aluminium silicate (Neusilin) as both carrier and coating material and dissolution media were selected based on the solubility studies. A mixture of carboxymethylcellulose sodium and carbomer was used as mucoadhesive polymers. Buccoadhesive tablets were prepared by direct compression. FTIR studies confirmed no interaction between drug and excipients. XRD studies indicated change/reduction in crystallinity of drug. The powder characteristics were evaluated by different flow parameters to comply with pharmacopoeial specifications. The dissolution studies for liquisolid compacts and tablet formulations were carried out and it was found that nifedipine liquisolid tablets formulated from bioadhesive polymers containing 49% liquisolid system, 17.5% carbomer, and 7.5% carboxymethylcellulose sodium showed the best results in terms of dissolution properties. Prepared formulation batches were evaluated for swelling, bioadhesion strength, ex vivo residence time, and permeability studies. The optimized batch was showing promising features of the system. Formulating nifedipine as a buccoadhesive tablet allows reduction in dose and offers better control over the plasma levels.

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Composite Microparticles Based on Natural Mucoadhesive Polymers with Promising Structural Properties to Protect and Improve the Antifungal Activity of Miconazole Nitrate

AAPS PharmSciTech ◽

10.1208/s12249-018-1175-0 ◽

2018 ◽

Vol 19 (8) ◽

pp. 3712-3722 ◽

Cited By ~ 2

Author(s):

G. Tejada ◽

M. C. Lamas ◽

M. Sortino ◽

V. A. Alvarez ◽

D. Leonardi

Keyword(s):

Antifungal Activity ◽

Structural Properties ◽

Mucoadhesive Polymers ◽

Miconazole Nitrate

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Development of Mucoadhesive Film-Forming Systems Containing Black Ginger Extract for Aphthous Ulcers

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.901.104 ◽

2021 ◽

Vol 901 ◽

pp. 104-110

Author(s):

Nattanich Wattanaphraya ◽

Somkamol Manchun ◽

Siriporn Taokaew ◽

Worawut Kriangkrai

Keyword(s):

Film Formation ◽

Aphthous Ulcer ◽

Alternative Formulation ◽

Ginger Extract ◽

Inflammatory Agent ◽

Mucoadhesive Polymers ◽

Aphthous Ulcers ◽

Film Forming ◽

Gradual Release

Film-forming systems (FFSs) were developed by using Eudragit® E100 as a film former. Kaempferia parviflora (black ginger) extract was used as an anti-inflammatory agent for aphthous ulcers. The FFS could rapidly form a thin film in only 5 s when it was applied to a wet surface e.g. an aphthous ulcer. When the FFS was applied to a dry surface, the FFS without extract could form a film in 2-4 min. The incorporation of this extract contributed to delaying the film-formation time in the dry state; hence, the film-forming time increased to 6-8 min. The mucoadhesive property of FFSs was verified with the wash-off method. To simulate oromucosal conditions, the FFSs were applied on a cellophane membrane coated with mucin and washed by phosphate buffer of pH 6.8. The formulations without mucoadhesive polymers could not withstand flushing with a medium for more than 8 min without dislodging. Therefore, three different mucoadhesive agents were trialed: PVP K90, HPMC E15 LV, and HPC SL. The highest adhesion results were obtained when HPMC was added at 5%(w/w) as well as, the residence time was 22 min. In vitro release of black ginger extract from FFS showed a gradual release for 2 h. This study indicated that the FFS with HPMC E15 LV was an appropriate alternative formulation as a local delivery system for an aphthous ulcer.

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