Mucoadhesive Delivery Systems. I. Evaluation of Mucoadhesive Polymers for Buccal Tablet Formulation

2004 ◽  
Vol 30 (9) ◽  
pp. 985-993 ◽  
Author(s):  
Noha Adel Nafee ◽  
Fatma Ahmed Ismail ◽  
Nabila Ahmed Boraie ◽  
Lobna Mohamed Mortada
Keyword(s):  
Delivery Systems ◽  
Tablet Formulation ◽  
Mucoadhesive Polymers ◽  
Buccal Tablet

scholarly journals OPTIMASI FORMULA TABLET BUKAL MUKOADHESIVE GLIBENKLAMID MENGGUNAKAN MATRIKS CMC NA SERTA ASAM OLEAT SEBAGAI ENHANCHER

2021 ◽  
Vol 4 (1) ◽  
pp. 38-43
Author(s):  
ASA FALAHI ◽  
DEWI RASHATI
Keyword(s):  
Oleic Acid ◽  
Physical Properties ◽  
Hardness Test ◽  
Oral Tablet ◽  
Mucoadhesive Polymers ◽  
Buccal Tablet ◽  
Mucoadhesive Tablets ◽  
Test Requirements ◽  
Buccal Tablets ◽  
Tablet Hardness

Glibenclamide is a sulfonylurea class of antidiabetic drugs that works by stimulating insulin secretion in the pancreas so that it is effective only when the β-cells of the pancreas can still produce. The glibenclamide dosage form that is on the market is a conventional oral tablet which has various disadvantages in terms of pharmacokinetics. Based on this, it is necessary to develop a more effective drug delivery system for glibenclamide in order to avoid first-pass metabolism so as to increase the bioavailability of glibenclamide, namely by making mucoadhesive buccal tablets. This glibenclamide mucoadhesive buccal tablet is formulated using a variety of mucoadhesive polymers, namely CMC Na and oleic acid as enhancers. The manufacture of four mucoadhesive buccal tablet formulas used the direct compression method. The results of the weight uniformity test showed that they did not meet the NP requirements specified, all formulas had an NP of more than 15. The tablet hardness test also showed results that did not meet the test requirements. However, the results of the physical properties of the brittleness, pH and swelling index showed the results that met the test requirements. In this research, the optimum variation of CMC Na polymer and oleic acid as enhancers to physical properties (hardness, brittleness, pH, swelling ability) and the release of glibenclamide mucoadhesive tablets were CMC Na of 37.5 mg and oleic acid of 3.5. ml.

scholarly journals Computer Aided Formulation and Characterization of Propranolol Hcl Buccal Tablet Using Polymeric Blend

2017 ◽  
Vol 8 (1) ◽  
pp. 1-13
Author(s):  
Sana Hanif ◽  
Nadeem Irfan ◽  
Zeeshan Danish ◽  
Nisaar Hussain ◽  
Muhammad Ali ◽  
...  
Keyword(s):  
Release Kinetics ◽  
Hydroxypropyl Methylcellulose ◽  
Continuous Release ◽  
Mucoadhesive Polymers ◽  
Propranolol Hcl ◽  
Physico Chemical ◽  
Buccal Tablet ◽  
Intelligence Approach

The current study was aimed to formulate a continuous release mucoadhesive buccal tablet containing propranolol HCl. The type and quantities of polymers as well as method of compression were set in a preliminary study (F1-F13). Direct compression method was employed in the main study (F14-F24) using Carbopol® 934P (CP), ethylcellulose (EC), sodium alginate (SA), hydroxypropyl methylcellulose (HPMC k4M) and carboxymethylcellulose (CMC) as mucoadhesive polymers and were tested for physicochemical tests i.e. swellability, surface pH, mucoadhesive time, mucoadhesive strength, in vitro release etc. Results obtained from the study were optimized using NeuralPower® 3.1, an artificial intelligence approach. Against the desirability of physico-chemical parameters, the software optimized the ingredients as HPMC (150mg), CMC (25mg), CP (20mg) and EC (20mg). Outcome revealed that HPMC primarily contributed to the physicochemical properties of mucoadhesive formulation. To compare prediction, optimized ingredients were formulated (F25) and tested. The swellability index of confirmation formulation (F25) was 102% at 6 h. As predicted, similar release pattern was of F25 was obtained as 26% (0.5h), 34% (1h), 40% (2h), 45% (3h), 50% (4h), 62% (5h), 76% (6h), 85% (7h) and 97% (8h) respectively. For release kinetics, DD solver® suggested the release of the drug to be non-Fickian.

Mucoadhesive Polymers for Drug Delivery Systems

2017 ◽  
pp. 89-113 ◽  
Author(s):  
Inderbir Singh ◽  
Pravin Pawar ◽  
Ebunoluwa A. Sanusi ◽  
Oluwatoyin A. Odeku
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Mucoadhesive Polymers

Recent Advances on Vaginal delivery for the Treatment of Vulvovaginal candidiasis

2020 ◽  
Vol 13 ◽  
Author(s):  
Sandeep Kaur ◽  
Sukhbir Kaur
Keyword(s):  
Vaginal Delivery ◽  
Residence Time ◽  
Antifungal Agents ◽  
Delivery Systems ◽  
Vulvovaginal Candidiasis ◽  
Sexual Activities ◽  
Mucoadhesive Polymers ◽  
Effective Delivery ◽  
Vaginal Delivery Systems ◽  
Treatment Of Infection

Background: Vulvovaginal candidiasis (VVC) is a common vaginal infection caused by candida species, affecting 70% of the women. It may occur due to the imbalance in the vaginal micro-biodata, pregnancy, diabetes, use of antibiotics, frequent sexual activities or AIDS. Aim: The main aim of this review is to provide overview about different vaginal delivery systems for the administration of antifungal agents like conventional, mucoadhesive and muco-penetrating delivery systems. Method: The conventional delivery systems available are having limited efficacy due to the less residence time and adverse effects. In order to overcome these issues, delivery system with mucoadhesive and muco-penetrating properties is required. Mucoadhesive polymers are having excellent binding properties with mucin and thus increasing residence time. On the other hand, muco-penetrating polymers transport the antifungal agents across the mucus layer. Results: This review summarizes the pathophysiology of VVC along with novel delivery systems for the treatment of infection through mucoadhesive and muco-penetrating approaches. Surface modifications of nano/ microparticles with mucoadhesive or muco-penetrating particles may results delivery systems with improved therapeutic efficacy. Conclusion: Based on the available data conventional and mucoadhesive drug delivery systems have some limitations, still requires improvement/ development for safe and effective delivery of antifungal agents.

scholarly journals MUCOADHESIVE POLYMERS AS EFFICIENT DRUG DELIVERY SYSTEMS

2015 ◽  
Vol 38 (1) ◽  
pp. 47-60
Author(s):  
Gamal El-Gindy ◽  
Mona El-Mahdy ◽  
Ghareb Soliman ◽  
Abeer Hassan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Mucoadhesive Polymers

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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