scholarly journals Comparison of hematological parameters, iron levels, and oxidative stress in women with and without breast cancer: A case- control study

2017 ◽  
Vol 31 (1) ◽  
pp. 762-767 ◽  
Author(s):  
Afsaneh Rajizadeh ◽  
Hassan Mozaffari-Khosravi ◽  
Javad Zavar-reza ◽  
Seyyed Mostafa Shiryazdi
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Case Control Study ◽  
Hematological Parameters ◽  
Case Control ◽  
And Oxidative Stress ◽  
Control Study

scholarly journals Role of Lipid and Oxidative Stress in Psoriatic Patients - A Case Control Study

2021 ◽  
Vol 10 (3) ◽  
pp. 132-136
Author(s):  
Roshan Kumar Jha ◽  
Akansha Singh ◽  
Priya Koundal ◽  
Ranjit Sidram Ambad
Keyword(s):  
Oxidative Stress ◽  
Case Control Study ◽  
Case Control ◽  
And Oxidative Stress ◽  
Control Study

scholarly journals Association between seminal plasma neopterin and oxidative stress in male infertility: A case-control study

2018 ◽  
Vol 16 (2) ◽  
pp. 93-100 ◽  
Author(s):  
Tayebeh Ghiasvand ◽  
Mohammad Taghi Goodarzi ◽  
Gholamreza Shafiee ◽  
Alireza Zamani ◽  
Jamshid Karimi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Male Infertility ◽  
Seminal Plasma ◽  
Case Control Study ◽  
Case Control ◽  
And Oxidative Stress ◽  
Control Study

Altered Levels of Salivary 8-oxo-7-hydrodeoxyguanosine in Breast Cancer

2016 ◽  
Vol 1 (2) ◽  
pp. 171-177 ◽  
Author(s):  
M. Gornitsky ◽  
A.M. Velly ◽  
S. Mohit ◽  
M. Almajed ◽  
H. Su ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Case Control Study ◽  
Redox Homeostasis ◽  
Growth Factor Receptor ◽  
Case Control ◽  
Enzyme Linked Immunosorbent Assay ◽  
Current Case ◽  
Modified Dna ◽  
Control Study

Oxidative stress has been implicated in the pathogenesis of breast cancer (BC). To determine whether BC is associated with altered salivary redox homeostasis, we performed a case-control study assessing the relationship between BC and 8-oxo-7-hydrodeoxyguanosine (8-oxodG), a marker for oxidative damage to DNA. Enzyme-linked immunosorbent assay for 8-oxodG was used on whole, unstimulated saliva of 134 BC patients and 226 healthy controls. Associations of the redox data were assessed by analysis of variance and logistic regression analysis. Our results revealed that there were 1) significantly lower mean levels of salivary 8-oxodG in BC patients versus controls ( P = 0.0005), 2) significantly lower levels among participants who did not receive radiotherapy and/or chemotherapy as compared with controls ( P < 0.0001), 3) significantly lower levels among BC patients who did not receive these treatments than among those who did ( P < 0.02), 4) and no significant differences in mean 8-oxodG levels among BC patients positive or negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 ( P ≥ 0.08). Our results suggest that BC is associated with decreased levels of oxidatively modified DNA in saliva. Knowledge Transfer Statement: The results of our current case-control study indicate that the molecular biomarker of oxidative stress 8-oxo-7-hydrodeoxyguanosine, measured from saliva, is associated with breast cancer. Our findings may provide the basis for future studies on molecular biomarkers of oxidative stress and breast cancer using saliva as an accessible and noninvasive tissue.

scholarly journals Association of CYBA gene (-930 A/G and 242 C/T) polymorphisms with oxidative stress in breast cancer: a case-control study

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5509 ◽  
Author(s):  
Mohini A. Tupurani ◽  
Chiranjeevi Padala ◽  
Kaushik Puranam ◽  
Rajesh K. Galimudi ◽  
Keerthi Kupsal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Case Control Study ◽  
Case Control ◽  
Breast Cancer Patients ◽  
Functional Polymorphisms ◽  
Increased Risk ◽  
Cancer Initiation ◽  
Control Study ◽  
Cyba Gene

Background Oxidative stress (OS) is a key characteristic feature in cancer initiation and progression. Among multiple cancers, NADPH oxidase (NOX) dependent free radical production is implicated in oxidative stress. P22phox, a subunit of NADPH oxidase encoded by the CYBA gene has functional polymorphisms associated with various complex diseases. The present study was aimed to examine the importance and association of the functional polymorphisms of CYBA gene (-930 A/G and 242 C/T) with the oxidative stress in breast cancer (BC) development and progression. Materials and Methods We have performed a case-control study on 300 breast cancer patients and 300 healthy individuals as controls to examine the role of CYBA gene -930 A/G and 242 C/T single nucleotide polymorphisms (SNPs) using As-PCR and PCR-RFLP assays and its association with OS as measured by plasma MDA levels. Linkage disequilibrium (LD) plots were generated using Haploviewtool and Multifactor dimensionality reduction (MDR) analysis was applied to assess high-order interactions between the SNPs. The Insilco analysis has been performed to predict the effect of SNPs on the gene regulation using online tools. Results We have found that genotype frequencies of CYBA gene -930 A/G and 242C/T polymorphism were significantly different between controls and BC patients (p < 0.05). The haplotype combination -930G/242C and -930G/242T were associated with 1.44 & 1.56 folds increased risk for breast cancer respectively. Further, the MDA levels were higher in the patients carrying -930G/242C and -930G/242T haplotype (p < 0.001). Our results have been substantiated by Insilco analysis. Conclusion Results of the present study suggest that GG genotype of -930 A/G polymorphism, -930G/242C and -930G/242T haplotypes of CYBA gene polymorphisms have shown association with higher MDA levels in breast cancer patients, signify that elevated oxidative stress might aid in increased risk for breast cancer initiation and progression.

Sign in / Sign up

Export Citation Format

Share Document