scholarly journals Association between seminal plasma neopterin and oxidative stress in male infertility: A case-control study

2018 ◽  
Vol 16 (2) ◽  
pp. 93-100 ◽  
Author(s):  
Tayebeh Ghiasvand ◽  
Mohammad Taghi Goodarzi ◽  
Gholamreza Shafiee ◽  
Alireza Zamani ◽  
Jamshid Karimi ◽  
...  
2020 ◽  
Vol 26 (1) ◽  
Author(s):  
Ayad Palani ◽  
Ahmed Alahmar

Abstract Background Oxidative stress has been implicated in male infertility through decrease in sperm quality. However, men with normal semen parameters (normozoospermia) may be unable to fertilize their partners even when they have normal sperm function. Thus, they would be considered infertile. The purpose of this study was to investigate the role of oxidative stress in the pathogenesis of unexplained male infertility. Methods In this case–control study, infertile men with normozoospermia (n = 46) and fertile control group (n = 21) underwent seminal fluid analyses according to WHO 2010 criteria. Serum and seminal plasma levels of total antioxidant capacity (TAC), glutathione, malondialdehyde, uric acid and albumin were also measured using colorimetric methods. Results The level of total antioxidant capacity in both serum and seminal plasma was significantly lower in normozoospermic infertile men in comparison with fertile group (p < 0.0001). However, no significant differences were observed in serum and seminal plasma levels of glutathione, uric acid, albumin and malondialdehyde between infertile and fertile groups. Conclusion Low TAC level induces oxidative stress and consequently causes sperm dysfunction and male infertility. Estimation of TAC can be a useful tool in the diagnosis of male infertility. Antioxidant supplementation should be considered in the treatment of oxidative stress-induced male infertility.


2021 ◽  
Vol 10 (3) ◽  
pp. 132-136
Author(s):  
Roshan Kumar Jha ◽  
Akansha Singh ◽  
Priya Koundal ◽  
Ranjit Sidram Ambad

2016 ◽  
Vol 52 (1) ◽  
pp. 51-60 ◽  
Author(s):  
V. E. Atabay ◽  
M. Lutfioğlu ◽  
B. Avci ◽  
E. E. Sakallioglu ◽  
A. Aydoğdu

Author(s):  
Kaspar Tootsi ◽  
Aare Märtson ◽  
Jaak Kals ◽  
Kaido Paapstel ◽  
Mihkel Zilmer

2013 ◽  
Vol 16 (1) ◽  
pp. 38-45 ◽  
Author(s):  
Wally Bartfay ◽  
Emma Bartfay

Approximately half of the Canadian adults have sedentary lifestyles that increase their risk of developing cardiovascular disease (CVD). Women are 10 times more likely to die from CVD than from any other disease. Their risk almost doubles with the onset of menopause, which may result in increased body iron burden and oxidative stress in sedentary women. Body iron burden may catalyze the production of cytotoxic oxygen species in vivo. We hypothesized that postmenopausal women who engage in moderate forms of aerobic exercise for at least 30 min three or more times per week would have significantly (i) lower levels of body iron burden, (ii) increased glutathione peroxidase (GPx) activity, and (iii) decreased oxidative stress in comparison to sedentary controls. An age-matched, case–control study was employed to examine the effects of active ( N = 25) versus sedentary ( N = 25) lifestyles in women aged 55–65 years on measures of body iron burden as quantified by total serum iron, transferrin saturation, and serum ferritin levels; GPx activity; and oxidative stress as quantified by 4-hydroxynonenal, malondialdehyde, and hexanal. Measures of body iron burden were significantly elevated in sedentary women in comparison to active women ( p < .001). Red cell GPx activity was higher in active women compared to sedentary women ( p < .001). Measures of oxidative stress were significantly higher in sedentary versus active women ( p < .001). These findings suggest that aerobic forms of exercise may mitigate the risk of developing CVD in postmenopausal women by improving antioxidant capacity and decreasing body iron burden.


2008 ◽  
Vol 9 (1) ◽  
Author(s):  
Andrew J Ghio ◽  
Jacqueline G Stonehuerner ◽  
Judy H Richards ◽  
Kay M Crissman ◽  
Victor L Roggli ◽  
...  

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