Prolactin-Producing Pituitary Adenoma Associated with Prolactin Cell Hyperplasia

2002 ◽  
Vol 13 (2) ◽  
pp. 157-166 ◽  
Author(s):  
Sergio Vidal ◽  
Eva Horvath ◽  
Luis V Syro ◽  
Humberto Uribe ◽  
Sandy Cohen ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Cell Hyperplasia ◽  
Prolactin Cell

Association of pituitary adenoma with neuronal christoma: A TEM study

1994 ◽  
Vol 52 ◽  
pp. 232-233
Author(s):  
Eva Horvath ◽  
Kalman Kovacs ◽  
B. W. Scheithauer ◽  
R. V. Lloyd ◽  
H. S. Smyth
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Pituitary Tumor ◽  
Nervous Tissue ◽  
Alternative Explanation ◽  
Growth Hormone Releasing Hormone ◽  
Cell Hyperplasia ◽  
Releasing Hormone ◽  
Secretory Neurons

The association of a pituitary adenoma with nervous tissue consisting of neuron-like cells and neuropil is a rare abnormality. In the majority of cases, the pituitary tumor is a chromophobic adenoma, accompanied by acromegaly. Histology reveals widely variable proportions of endocrine and nervous tissue in alternating or intermingled patterns. The lesion is perceived as a composite one consisting of two histogenetically distinct parts. It has been suggested that the neuronal component, morphologically similar to secretory neurons of the hypothalamus, may initiate adenoma formation by releasing stimulatory substances. Immunoreactivity for growth hormone releasing hormone (GRH) in the neuronal component of some cases supported this view, whereas other findings such as consistent lack of growth hormone (GH) cell hyperplasia in the lesions called for alternative explanation.Fifteen tumors consisting of a pituitary adenoma and a neuronal component have been collected over a 20 yr. period. Acromegaly was present in 11 patients, was equivocal in one, and absent in 3.

Pituitary Cushing's disease without adenoma

1980 ◽  
Vol 94 (3) ◽  
pp. 297-303 ◽  
Author(s):  
Adrian M. Schnall ◽  
Kalman Kovacs ◽  
Jerald S. Brodkey ◽  
Olof H. Pearson
Keyword(s):  
Pituitary Adenoma ◽  
Cushing’S Disease ◽  
Pituitary Adenomas ◽  
Great Majority ◽  
Serum Levels ◽  
Cushing's Disease ◽  
Serial Sections ◽  
Cell Hyperplasia ◽  
Biochemical Remission ◽  
Lower Limits

Abstract. Recent reports of patients with Cushing's disease who have been explored via the transsphenoidal route indicate that the great majority has pituitary adenomas. We report a patient with biochemically documented pituitary-based hypercortisolism who had a clinical and biochemical remission following hypophysectomy. Serial sections of the pituitary tissue removed showed hyperplasia of corticotroph cells but no adenoma. Hypophysectomy was complete as documented by serum levels of FSH, LH, TSH, prolactin, hGH and ACTH at the lower limits of the respective assays, with no response to appropriate stimuli. This case demonstrates that a minority of patients with Cushing's disease has corticotroph cell hyperplasia without a pituitary adenoma.

Silent mixed growth hormone cell-prolactin cell pituitary adenoma

1991 ◽  
Vol 2 (4) ◽  
pp. 230-234 ◽  
Author(s):  
Shigeru Furuhata ◽  
Toru Kameya ◽  
Mitsuhiro Otani ◽  
Yoshinori Shimamoto ◽  
Hideo Asada ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Prolactin Cell ◽  
Growth Hormone Cell

Combined thyrotroph and lactotroph cell hyperplasia simulating prolactin-secreting pituitary adenoma in long-standing primary hypothyroidism

1988 ◽  
Vol 29 (3) ◽  
pp. 218-226 ◽  
Author(s):  
Erik P. Pioro ◽  
Bernd W. Scheithauer ◽  
Edward R. Laws ◽  
Raymond V. Randall ◽  
Kalman T. Kovacs ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Primary Hypothyroidism ◽  
Cell Hyperplasia

Immunocytochemical study of the hypophysis in 25 dogs with pituitary-dependent hyperadrenocorticism

1982 ◽  
Vol 101 (1) ◽  
pp. 15-24 ◽  
Author(s):  
Mark E. Peterson ◽  
Dorothy T. Krieger ◽  
William D. Drucker ◽  
Nicholas S. Halmi
Keyword(s):  
Pituitary Adenoma ◽  
Pituitary Adenomas ◽  
Immunocytochemical Staining ◽  
Pars Intermedia ◽  
Positive Staining ◽  
Pars Distalis ◽  
Immunocytochemical Study ◽  
Double Immunostaining ◽  
Cell Hyperplasia ◽  
Intense Staining

Abstract. Pituitary adenomas were found in 21 (84%) of 25 dogs with spontaneous pituitary-dependent hyperadrenocorticism. Six dogs had pars intermedia adenomas, whereas 15 had tumours of the pars distalis. Diffuse corticotroph cell hyperplasia was found in 1 of the 4 pituitaries without adenoma; in 2 dogs with pituitary adenoma, coexisting hyperplasia of the surrounding corticotrophs was also present. Immunocytochemical staining of the pituitaries revealed positive staining for ACTH, β-lipotrophin, and β-endorphin in the majority of both pars distalis and pars intermedia adenomas. The most frequent and intense staining was found with anti-β-endorphin. In most part intermedia tumours, many cells stained strongly for α-MSH; double immunostaining of one pars intermedia adenoma for ACTH and α-MSH showed that some tumour cells stained only for ACTH or α-MSH whereas others contained both peptides. Only occasional cells stained for α-MSH in pars distalis adenomas.

Mixed growth hormone cell- prolactin cell pituitary adenoma with acromegaly: α-subunit most growth hormone cells

1992 ◽  
Vol 3 (4) ◽  
pp. 201-204 ◽  
Author(s):  
Shigeru Furuhata ◽  
Toru Kameya ◽  
Tomoko Tsuruta ◽  
Heiji Naritaka ◽  
Mitsuhiro Otani ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Α Subunit ◽  
Prolactin Cell ◽  
Growth Hormone Cell

scholarly journals Lymphocytic Adenohypophysitis

1988 ◽  
Vol 15 (1) ◽  
pp. 38-43 ◽  
Author(s):  
Michael W. McDermott ◽  
Donald E. Griesdale ◽  
Kenneth Berry ◽  
G. Edward Wilkins
Keyword(s):  
Pituitary Adenoma ◽  
Clinical Picture ◽  
Post Partum ◽  
Prolactin Cell ◽  
Pituitary Disease ◽  
Lymphocytic Adenohypophysitis ◽  
Post Partum Period

ABSTRACT:Lymphocytic adenohypophysitis (LAH) is an uncommon disorder in the spectrum of pituitary disease. Twenty-three cases proven by biopsy or at autopsy have been reported since 1962. We report 2 further cases and review the etiology, immunology and pathology of the disease. The diagnosis should be considered in afemale patient who presents during the post-partum period with the clinical picture of a non-functional or prolactin cell pituitary adenoma and evidence of hypopituitarism.

Pituitary Prolactin Cell Hyperplasia

1980 ◽  
Vol 12 (2) ◽  
pp. 87-95 ◽  
Author(s):  
K. Kovacs ◽  
G. Ilse ◽  
N. Ryan ◽  
D.J. McComb ◽  
E. Horvath ◽  
...  
Keyword(s):  
Cell Hyperplasia ◽  
Prolactin Cell ◽  
Pituitary Prolactin

The effect of bromocriptine on mammary-gland ultrastructure of hyperprolactinemic rats

1984 ◽  
Vol 42 ◽  
pp. 204-205
Author(s):  
I.C. Murray
Keyword(s):  
Mammary Gland ◽  
Dopamine Agonist ◽  
Alveolar Epithelium ◽  
Mammary Glands ◽  
Female Rats ◽  
Control Group ◽  
Cell Hyperplasia ◽  
Once Daily ◽  
Long Evans

In women, hyperprolactinemia is often due to a prolactin (PRL)-secreting adenoma or PRL cell hyperplasia. RRL excess stimulates the mammary glands and causes proliferation of the alveolar epithelium. Bromocriptine, a dopamine agonist, inhibits PRL secretion and is given to women to treat nonpuerperal galactorrhea. Old female rats have been reported to have PRL cell hyperplasia or adenoma leading to PRL hypersecretion and breast stimulation. Herein, we describe the effect of bromocriptine and consequently the reduction in serum PRL levels on the ultrastructure of rat mammary glands.Female Long-Evans rats, 23 months of age, were divided into control and bromocriptine-treated groups. The control animals were injected subcutaneously once daily with a 10% ethanol vehicle and were later divided into a normoprolactinemic control group with serum PRL levels under 30 ng/ml and a hyperprolactinemic control group with serum PRL levels above 30 ng/ml.

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