Silent mixed growth hormone cell-prolactin cell pituitary adenoma

1991 ◽  
Vol 2 (4) ◽  
pp. 230-234 ◽  
Author(s):  
Shigeru Furuhata ◽  
Toru Kameya ◽  
Mitsuhiro Otani ◽  
Yoshinori Shimamoto ◽  
Hideo Asada ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Prolactin Cell ◽  
Growth Hormone Cell

Mixed growth hormone cell- prolactin cell pituitary adenoma with acromegaly: α-subunit most growth hormone cells

1992 ◽  
Vol 3 (4) ◽  
pp. 201-204 ◽  
Author(s):  
Shigeru Furuhata ◽  
Toru Kameya ◽  
Tomoko Tsuruta ◽  
Heiji Naritaka ◽  
Mitsuhiro Otani ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Α Subunit ◽  
Prolactin Cell ◽  
Growth Hormone Cell

Association of pituitary adenoma with neuronal christoma: A TEM study

1994 ◽  
Vol 52 ◽  
pp. 232-233
Author(s):  
Eva Horvath ◽  
Kalman Kovacs ◽  
B. W. Scheithauer ◽  
R. V. Lloyd ◽  
H. S. Smyth
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Pituitary Tumor ◽  
Nervous Tissue ◽  
Alternative Explanation ◽  
Growth Hormone Releasing Hormone ◽  
Cell Hyperplasia ◽  
Releasing Hormone ◽  
Secretory Neurons

The association of a pituitary adenoma with nervous tissue consisting of neuron-like cells and neuropil is a rare abnormality. In the majority of cases, the pituitary tumor is a chromophobic adenoma, accompanied by acromegaly. Histology reveals widely variable proportions of endocrine and nervous tissue in alternating or intermingled patterns. The lesion is perceived as a composite one consisting of two histogenetically distinct parts. It has been suggested that the neuronal component, morphologically similar to secretory neurons of the hypothalamus, may initiate adenoma formation by releasing stimulatory substances. Immunoreactivity for growth hormone releasing hormone (GRH) in the neuronal component of some cases supported this view, whereas other findings such as consistent lack of growth hormone (GH) cell hyperplasia in the lesions called for alternative explanation.Fifteen tumors consisting of a pituitary adenoma and a neuronal component have been collected over a 20 yr. period. Acromegaly was present in 11 patients, was equivocal in one, and absent in 3.

Co-secreting TSH and growth hormone pituitary adenoma

2019 ◽  
Author(s):  
Hatem Eid ◽  
B Andrabi ◽  
R Ismail ◽  
H Nizar ◽  
G Maltese ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma

Pituitary adenoma producing growth hormone and adrenocorticotropin: a histological, immunocytochemical, electron microscopic, and in situ hybridization study

1998 ◽  
Vol 88 (6) ◽  
pp. 1111-1115 ◽  
Author(s):  
Kalman Kovacs ◽  
Eva Horvath ◽  
Lucia Stefaneanu ◽  
Juan Bilbao ◽  
William Singer ◽  
...  
Keyword(s):  
Growth Hormone ◽  
In Situ Hybridization ◽  
Pituitary Adenoma ◽  
Immunoelectron Microscopy ◽  
Secretory Granules ◽  
Cell Types ◽  
Content Type ◽  
Separate Cell ◽  
Fine Print

✓ The authors report on the morphological features of a pituitary adenoma that produced growth hormone (GH) and adrenocorticotropic hormone (ACTH). This hormone combination produced by a single adenoma is extremely rare; a review of the available literature showed that only one previous case has been published. The tumor, which was removed from a 62-year-old man with acromegaly, was studied by histological and immunocytochemical analyses, transmission electron microscopy, immunoelectron microscopy, and in situ hybridization. When the authors used light microscopy, the tumor appeared to be a bimorphous mixed pituitary adenoma composed of two separate cell types: one cell population synthesized GH and the other ACTH. The cytogenesis of pituitary adenomas that produce more than one hormone is obscure. It may be that two separate cells—one somatotroph and one corticotroph—transformed into neoplastic cells, or that the adenoma arose in a common stem cell that differentiated into two separate cell types. In this case immunoelectron microscopy conclusively demonstrated ACTH in the secretory granules of several somatotrophs. This was associated with a change in the morphological characteristics of secretory granules. Thus it is possible that the tumor was originally a somatotropic adenoma that began to produce ACTH as a result of mutations that occurred during tumor progression.

scholarly journals Evaluation of the Antiangiogenic Effects of Octreotide on Growth Hormone-producing Pituitary Adenoma using Arterial Spin-labeling Perfusion Imaging

2015 ◽  
Vol 14 (1) ◽  
pp. 73-76 ◽  
Author(s):  
Naoto SAKAI ◽  
Shuhei YAMASHITA ◽  
Yasuo TAKEHARA ◽  
Harumi SAKAHARA ◽  
Satoshi BABA ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Perfusion Imaging ◽  
Arterial Spin Labeling ◽  
Spin Labeling

Stereotactic conformal radiotherapy in patients with growth hormone–secreting pituitary adenoma

2004 ◽  
Vol 59 (4) ◽  
pp. 1088-1096 ◽  
Author(s):  
Stefanie Milker-Zabel ◽  
Angelika Zabel ◽  
Peter Huber ◽  
Wolfgang Schlegel ◽  
Michael Wannenmacher ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Conformal Radiotherapy
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