Insulin Resistance, Leptin and TNF-α System in Morbidly Obese Women after Gastric Bypass

2003 ◽  
Vol 13 (4) ◽  
pp. 615-621 ◽  
Author(s):  
Ana Molina ◽  
Joan Vendrell ◽  
Cristina Gutiérrez ◽  
Inmaculada Simón ◽  
C. Masdevall ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Gastric Bypass ◽  
Morbidly Obese ◽  
Obese Women ◽  
Tnf Α

Impact of Laparoscopic Roux-en-Y Gastric Bypass on Metabolic Syndrome, Inflammation, and Insulin Resistance in Super Versus Morbidly Obese Women

2008 ◽  
Vol 19 (5) ◽  
pp. 577-582 ◽  
Author(s):  
Antonio Iannelli ◽  
Rodolphe Anty ◽  
Thierry Piche ◽  
Moucef Dahman ◽  
Philippe Gual ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Gastric Bypass ◽  
Morbidly Obese ◽  
Obese Women

GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle

2006 ◽  
Vol 27 (2) ◽  
pp. 114-121 ◽  
Author(s):  
Jung-Jun Park ◽  
Jason R. Berggren ◽  
Matthew W. Hulver ◽  
Joseph A Houmard ◽  
Eric P. Hoffman
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Weight Loss ◽  
Gastric Bypass ◽  
Insulin Action ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Morbidly Obese ◽  
Obese Women ◽  
Cross Sectional

Obesity is associated with insulin resistance in skeletal muscle; accordingly, weight loss dramatically improves insulin action. We sought to identify molecular remodeling of muscle commensurate with weight loss that could explain improvements in insulin action. Muscle from morbidly obese women was studied before and after gastric bypass surgery. Gastric bypass surgery significantly reduced body mass by ∼45% and improved insulin action. We then assessed mRNA profiles using a stringent statistical analysis (statistical concordance with three probe set algorithms), with validation in a cross-sectional study of lean ( n = 8) vs. morbidly obese ( n = 8) muscle. Growth factor receptor-bound protein 14 (GRB14), glycerol-3-phosphate dehydrogenase 1 (GPD1), and growth differentiation factor 8 (GDF8; myostatin) significantly decreased ∼2.4-, 2.2-, and 2.4-fold, respectively, after weight loss (gastric bypass). Increased expression of these transcripts was associated with increased obesity in the cross-sectional group (lean vs. morbidly obese muscle). Each transcript was validated by real-time quantitative RT-PCR assays in both study groups. Using Ingenuity Pathway Analysis, we show that all three transcripts are involved in the same regulatory network including AKT1, IGF1, TNF, PPARG, and INS. These results suggest that GRB14, GPD1, and GDF8 are weight loss-responsive genes in skeletal muscle and that the observed transcriptional modulation of these would be expected to improve insulin signaling, decrease triglyceride synthesis, and increase muscle mass, respectively, with weight loss. Thus our data provide a possible regulatory pathway involved in the development of insulin resistance in the morbidly obese state, and improvement of insulin resistance with weight loss.

Analysis of genome-wide methylation profile of obese women submitted to gastric bypass identifies genes involved in AMPK signaling and insulin resistance pathways

2017 ◽  
Vol 13 (10) ◽  
pp. S104-S105
Author(s):  
Carolina F Nicoletti ◽  
Vitor Pinhanelli ◽  
Marcela Pinhel ◽  
Natalia Noronha ◽  
Bruno de Oliveira ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Gastric Bypass ◽  
Methylation Profile ◽  
Obese Women ◽  
Ampk Signaling ◽  
Genome Wide

PL-27: The effect of laparoscopic Roux-en-Y gastric bypass on urinary incontinence in morbidly obese women

2008 ◽  
Vol 4 (3) ◽  
pp. 298-299
Author(s):  
Rajesh Laungani ◽  
Arthur M. Carlin ◽  
Nicole Seleno ◽  
Todd Hoffman
Keyword(s):  
Gastric Bypass ◽  
Urinary Incontinence ◽  
Morbidly Obese ◽  
Obese Women

scholarly journals Striatal dopamine receptor binding in morbidly obese women before and after gastric bypass surgery and its relationship with insulin sensitivity

Diabetologia ◽  
2014 ◽  
Vol 57 (5) ◽  
pp. 1078-1080 ◽  
Author(s):  
Barbara A. de Weijer ◽  
Elsmarieke van de Giessen ◽  
Ignace Janssen ◽  
Frits J. Berends ◽  
Arnold van de Laar ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Insulin Sensitivity ◽  
Receptor Binding ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Morbidly Obese ◽  
Obese Women ◽  
Before And After ◽  
Striatal Dopamine Receptor ◽  
Dopamine Receptor Binding

Relation between insulin resistance and serum concentrations of IL-6 and TNF-α in overweight or obese women with early stage breast cancer

Cytokine ◽  
2005 ◽  
Vol 31 (4) ◽  
pp. 264-269 ◽  
Author(s):  
Guzin Gonullu ◽  
Canan Ersoy ◽  
Alpaslan Ersoy ◽  
Turkkan Evrensel ◽  
Bilkay Basturk ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Insulin Resistance ◽  
Early Stage ◽  
Early Stage Breast Cancer ◽  
Serum Concentrations ◽  
Obese Women ◽  
Tnf Α

scholarly journals Heme- and nonheme-iron absorption and iron status 12 mo after sleeve gastrectomy and Roux-en-Y gastric bypass in morbidly obese women

2012 ◽  
Vol 96 (4) ◽  
pp. 810-817 ◽  
Author(s):  
Manuel Ruz ◽  
Fernando Carrasco ◽  
Pamela Rojas ◽  
Juana Codoceo ◽  
Jorge Inostroza ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Iron Absorption ◽  
Iron Status ◽  
Nonheme Iron ◽  
Morbidly Obese ◽  
Obese Women

scholarly journals Metabolically Healthy versus Unhealthy Morbidly Obese: Chronic Inflammation, Nitro-Oxidative Stress, and Insulin Resistance

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1199 ◽  
Author(s):  
Adriana Cӑtoi ◽  
Alina Pârvu ◽  
Andra Andreicuț ◽  
Aurel Mironiuc ◽  
Alexandra Crӑciun ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Chronic Inflammation ◽  
Fasting Blood Glucose ◽  
Morbidly Obese ◽  
Model Assessment ◽  
Metabolic Disturbances ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Metabolically Healthy

Metabolically heathy obesity is characterised by the presence of obesity in the absence of metabolic disturbances. The aim of our study was to analyse pro-inflammatory, nitro-oxidative stress, and insulin-resistance (IR) markers in metabolically healthy morbidly obese (MHMO) with respect to metabolically unhealthy morbidly obese (MUHMO) with metabolic syndrome (MS) and to identify the potential predictors of MS in the MHMO group. Two groups of MHMO and MUHMO with MS were analysed. We evaluated serum high sensitivity C reactive protein (hsCRP), tumor necrosis factor alpha (TNF-α), chemerin, nitrite and nitrate (NOx), total oxidant status (TOS), total antioxidant response (TAR), fasting blood glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR.) MHMO have similar hsCRP and TNF-α values as the MUHMO with MS, while chemerin was significantly lower in MHMO. NOx was higher in MUHMO with MS patients, while no difference regarding TOS and TAR was found between the two groups. HOMA-IR and insulin values were lower in MHMO as compared to the MUHMO with MS group. Insulin, HOMA-IR, and chemerin were identified predictors of MS in MHMO. In conclusion, MHMO and MUHMO display similarities and differences in terms of chronic inflammation, nitro-oxidative stress, and IR. Markers of IR and chemerin are possible predictors of MS in MHMO.

Laparoscopic Roux-En-Y Gastric Bypass Versus Sleeve Gastrectomy on Pelvic Floor Disorders in Morbidly Obese Women: a Prospective Monocentric Pilot Study

2018 ◽  
Vol 29 (2) ◽  
pp. 609-616 ◽  
Author(s):  
Clémentine Mazoyer ◽  
Patrick Treacy ◽  
Laurent Turchi ◽  
Paul Antoine Lehur ◽  
Emmanuel Benizri ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Pilot Study ◽  
Pelvic Floor ◽  
Pelvic Floor Disorders ◽  
Morbidly Obese ◽  
Obese Women

scholarly journals A High Protein Diet Is More Effective in Improving Insulin Resistance and Glycemic Variability Compared to a Mediterranean Diet—A Cross-Over Controlled Inpatient Dietary Study

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4380
Author(s):  
Francesca Tettamanzi ◽  
Vincenzo Bagnardi ◽  
Panayiotis Louca ◽  
Ana Nogal ◽  
Gianna Serafina Monti ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glucose Monitoring ◽  
High Protein Diet ◽  
Glycemic Variability ◽  
High Protein ◽  
Morbidly Obese ◽  
Obese Women ◽  
Dietary Interventions ◽  
Microbiome Composition ◽  
Insulin Resistant

The optimal dietary pattern to improve metabolic function remains elusive. In a 21-day randomized controlled inpatient crossover feeding trial of 20 insulin-resistant obese women, we assessed the extent to which two isocaloric dietary interventions—Mediterranean (M) and high protein (HP)—improved metabolic parameters. Obese women were assigned to one of the following dietary sequences: M–HP or HP–M. Cardiometabolic parameters, body weight, glucose monitoring and gut microbiome composition were assessed. Sixteen women completed the study. Compared to the M diet, the HP diet was more effective in (i) reducing insulin resistance (insulin: Beta (95% CI) = −6.98 (−12.30, −1.65) µIU/mL, p = 0.01; HOMA-IR: −1.78 (95% CI: −3.03, −0.52), p = 9 × 10−3); and (ii) improving glycemic variability (−3.13 (−4.60, −1.67) mg/dL, p = 4 × 10−4), a risk factor for T2D development. We then identified a panel of 10 microbial genera predictive of the difference in glycemic variability between the two diets. These include the genera Coprococcus and Lachnoclostridium, previously associated with glucose homeostasis and insulin resistance. Our results suggest that morbidly obese women with insulin resistance can achieve better control of insulin resistance and glycemic variability on a high HP diet compared to an M diet.

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