Overexpression of Heat Shock Factor 1 inhibits Butyrate-Induced Differentiation in Colon Cancer Cells

2005 ◽  
Author(s):  
Jiyang Cai ◽  
Jiyang Cai ◽  
Ward Kirlin ◽  
Yan Chen ◽  
Xuexian Yan ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Heat Shock ◽  
Cancer Cells ◽  
Heat Shock Factor ◽  
Heat Shock Factor 1 ◽  
Colon Cancer Cells ◽  
Induced Differentiation

scholarly journals Overexpression of heat shock factor 1 inhibits butyrate-induced differentiation in colon cancer cells

2006 ◽  
Vol 11 (3) ◽  
pp. 199 ◽  
Author(s):  
Jiyang Cai ◽  
Ward G. Kirlin ◽  
Yan Chen ◽  
Xuexian Yan ◽  
Dean P. Jones ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Heat Shock ◽  
Cancer Cells ◽  
Heat Shock Factor ◽  
Heat Shock Factor 1 ◽  
Colon Cancer Cells ◽  
Induced Differentiation

Ets1 and heat shock factor 1 regulate transcription of the Transformer 2β gene in human colon cancer cells

2013 ◽  
Vol 48 (11) ◽  
pp. 1222-1233 ◽  
Author(s):  
Keisuke Kajita ◽  
Yuki Kuwano ◽  
Naruka Kitamura ◽  
Yuzuru Satake ◽  
Kensei Nishida ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Heat Shock ◽  
Cancer Cells ◽  
Human Colon ◽  
Heat Shock Factor ◽  
Heat Shock Factor 1 ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

scholarly journals Schizandrin A exhibits potent anticancer activity in colorectal cancer cells by inhibiting heat shock factor 1

2020 ◽  
Vol 40 (3) ◽  
Author(s):  
Bing-chen Chen ◽  
Shi-liang Tu ◽  
Bo-an Zheng ◽  
Quan-jin Dong ◽  
Zi-ang Wan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Heat Shock ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Hydrophobic Interactions ◽  
Heat Shock Factor ◽  
Luciferase Reporter ◽  
Heat Shock Factor 1

Abstract Heat shock factor 1 (HSF1) is a powerful multifaceted oncogenic modifier that plays a role in maintaining the protein balance of cancer cells under various stresses. In recent studies, there have been reports of increased expression of HSF1 in colorectal cancer (CRC) cells, and the depletion of the HSF1 gene knockdown has inhibited colon cancer growth both in vivo and in vitro. Therefore, HSF1 is a promising target for colon cancer treatment and chemoprevention. In the present study, we found that Schizandrin A (Sch A) significantly inhibited the growth of CRC cell lines by inducing cell cycle arrest, apoptosis and death. Through HSE luciferase reporter assay and quantitative PCR (qPCR), we identified Sch A as a novel HSF1 inhibitor. In addition, Sch A could effectively inhibit the induction of HSF1 target proteins such as heat-shock protein (HSP) 70 (HSP70) and HSP27, whether in heat shock or normal temperature culture. In the Surface Plasmon Resonance (SPR) experiment, Sch A showed moderate affinity with HSF1, further confirming that Sch A might be a direct HSF1 inhibitor. The molecular docking and molecular dynamic simulation results of HSF1/Sch A suggested that Sch A formed key hydrogen bond and hydrophobic interactions with HSF1, which may contribute to its potent HSF1 inhibition. These findings provide clues for the design of novel HSF1 inhibitors and drug candidates for colon cancer treatment.

scholarly journals Suppression of heat shock protein 27 expression promotes 5-fluorouracil sensitivity in colon cancer cells in a xenograft model

2012 ◽  
Vol 28 (4) ◽  
pp. 1269-1274 ◽  
Author(s):  
RYOHEI HAYASHI ◽  
YOSHIYUKI ISHII ◽  
HIROKI OCHIAI ◽  
ATSUSHI MATSUNAGA ◽  
TAKASHI ENDO ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cancer Cells ◽  
Xenograft Model ◽  
Heat Shock Protein 27 ◽  
Colon Cancer Cells

scholarly journals Inhibiting Heat Shock Factor 1 in Human Cancer Cells with a Potent RNA Aptamer

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e96330 ◽  
Author(s):  
H. Hans Salamanca ◽  
Marc A. Antonyak ◽  
Richard A. Cerione ◽  
Hua Shi ◽  
John T. Lis
Keyword(s):  
Heat Shock ◽  
Cancer Cells ◽  
Human Cancer ◽  
Heat Shock Factor ◽  
Heat Shock Factor 1 ◽  
Rna Aptamer ◽  
Human Cancer Cells
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