A Comparison of the Clinical Presentation and Survival of Patients With Resected Primary Pulmonary Atypical Carcinoid Tumors to Typical Carcinoid and Other Pulmonary Neuroendocrine Tumors

CHEST Journal ◽  
2010 ◽  
Vol 138 (4) ◽  
pp. 260A
Author(s):  
Jay Bhatt ◽  
Royce F. Calhoun ◽  
J.N. Young ◽  
David T. Cooke
Keyword(s):  
Neuroendocrine Tumors ◽  
Clinical Presentation ◽  
Carcinoid Tumors ◽  
Atypical Carcinoid ◽  
Typical Carcinoid

scholarly journals Case report of atypical carcinoid tumors of the larynx

2018 ◽  
Vol 5 (9) ◽  
pp. 4155
Author(s):  
Fatimah S. Alkhaliah ◽  
Ibrahim A. Almajed ◽  
Anwar S. Alkhalifah ◽  
Abdulltaif S. Alkhalifah ◽  
Khalid A. AlYahya ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Neuroendocrine Tumors ◽  
Histopathological Examination ◽  
Small Cell ◽  
Carcinoid Tumors ◽  
High Rate ◽  
Atypical Carcinoid ◽  
Typical Carcinoid ◽  
Laryngeal Tumors

Neuroendocrine tumors (NET) of the larynx are considered one of the rare disease; they represent only 1% of the laryngeal tumors. These tumors are very aggressive with a high rate of metastases. Diagnosis is done by computed tomography and confirmed by histopathological examination. Neuroendocrine tumors can be classified into four types based on histopathology: typical carcinoid tumors, atypical carcinoid tumors, small cell neuroendocrine tumors and paragangliomas. Atypical carcinoid tumor of the larynx is considered rare in occurrence. We report a rare laryngeal neuroendocrine tumor case.

Review of Neuroendocrine Carcinomas of the Larynx

1989 ◽  
Vol 98 (10) ◽  
pp. 780-790 ◽  
Author(s):  
Alfio Ferlito ◽  
Imrich Friedmann
Keyword(s):  
Personal Experience ◽  
Medical Literature ◽  
Clinical Importance ◽  
Small Cell ◽  
Paraneoplastic Syndromes ◽  
Carcinoid Tumors ◽  
Atypical Carcinoid ◽  
Typical Carcinoid ◽  
Ultrastructural Evidence ◽  
Neuroendocrine Carcinomas

Neuroendocrine carcinomas of the larynx are uncommon tumors of considerable scientific interest and clinical importance. They include typical carcinoid tumors, atypical carcinoid tumors, and small cell neuroendocrine carcinomas. This paper considers these neoplasms from a personal experience and reviews the relevant medical literature. About 200 cases of neuroendocrine carcinomas of the larynx have been reported. The diagnosis is based on light microscopy and is confirmed by ultrastructural evidence of neurosecretory granules. Histochemical and immunocytochemical investigations may support it. Paraneoplastic syndromes associated with laryngeal neuroendocrine carcinomas have been reported occasionally. The histogenesis, treatment, and prognosis of these lesions also are discussed.

scholarly journals Radiation Methods in the Diagnosis and Determination of Surgical Treatment Tactics for Primary Multiple Lung Carcinoid

2021 ◽  
Vol 102 (4) ◽  
pp. 227-231
Author(s):  
N. V. Nudnov ◽  
V. D. Сhkhikvadze ◽  
D. S. Kontorovich
Keyword(s):  
Surgical Treatment ◽  
Early Diagnosis ◽  
Clinical Oncology ◽  
Neuroendocrine Tumors ◽  
Who Classification ◽  
Carcinoid Tumors ◽  
Typical Carcinoid ◽  
Organ Sparing ◽  
Lung Carcinoid

The early and complete diagnosis of lung carcinoid tumors is of great interest in clinical oncology, since this is the basis for the possibility of using options for organ-sparing surgical treatment. According to the 2015 WHO classification, carcinoids belong to the group of neuroendocrine tumors and are divided into two types: a typical carcinoid and an atypical one. Based on the data available in the literature, there are from 0.2 to 2 cases per 100,000 population. The paper considers the possibilities of radiation studies in the early diagnosis of this tumor, as well as those of determining the tactics, type, and scope of surgical treatment.

scholarly journals Diagnostic Accuracy in Bronchial Carcinoid tumors is Dependent of Biopsy Size

2021 ◽  
Author(s):  
Ellen M. B. P. Reuling ◽  
Dwayne D. Naves ◽  
Johannes M. A. Daniels ◽  
Chris Dickhoff ◽  
Pim C. Kortman ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Rigid Bronchoscopy ◽  
Definitive Diagnosis ◽  
Carcinoid Tumors ◽  
Atypical Carcinoid ◽  
Typical Carcinoid ◽  
Medical Centers ◽  
Resection Specimen ◽  
Bronchial Biopsies ◽  
The Impact

Objective: Recently, 60% discordancy was reported for distinction between typical carcinoid and atypical carcinoid in preoperative biopsy compared to the resection specimen. This study investigated the impact of biopsy surface size, obtained with flexible and rigid bronchoscopy, on diagnostic accuracy of typical and atypical carcinoid. Methods: Biopsy-resection paired specimens of patients referred for treatment to Amsterdam University Medical Centers were retrieved. Bronchial biopsies were obtained either by flexible or rigid biopsy. The definitive diagnosis was based on the resection specimen. Diagnosis according to the 2015 WHO classification, mitoses and necrosis in biopsy and resection specimen, were independently re-evaluated by two pathologists. Results: After screening 298 patients, 64 biopsy-resection pairs with available tissue were included of which 34 (53%) were biopsied with flexible and 30 (47%) with rigid biopsy. In 35 (55%) patients, the tumor classification between the biopsy and resection specimen was concordant. The discordance in the remaining 29 cases (45%) was caused by misclassification of atypical as typical carcinoid in bronchoscopy specimens, predominantly in small flexible biopsies (59%, p=0.021). Of biopsies measuring <2 mm2, 79% were classified as discordant and 52% of the discordant biopsies measured <4 mm2. Conclusion: Histological classification in central carcinoid tumors is discordant in 45% of the biopsies, with increasing diagnostic accuracy in larger biopsies. Distinguishing carcinoid tumor into typical or atypical carcinoid on biopsies <4 mm2 should be discouraged. A cumulative biopsy surface of at least 4 mm2 tumor is preferred to increase the diagnostic accuracy which helps in optimal treatment planning.

scholarly journals Typical and Atypical Carcinoid Tumors of the Lung Are Characterized by 11q Deletions as Detected by Comparative Genomic Hybridization

1998 ◽  
Vol 153 (4) ◽  
pp. 1089-1098 ◽  
Author(s):  
Axel K. Walch ◽  
Horst F. Zitzelsberger ◽  
Michaela M. Aubele ◽  
Anita E. Mattis ◽  
Manfred Bauchinger ◽  
...  
Keyword(s):  
Comparative Genomic Hybridization ◽  
Carcinoid Tumors ◽  
Comparative Genomic ◽  
Atypical Carcinoid ◽  
Genomic Hybridization

scholarly journals Molecular Pathology of Well-Differentiated Pulmonary and Thymic Neuroendocrine Tumors: What Do Pathologists Need to Know?

2021 ◽  
Vol 32 (1) ◽  
pp. 154-168 ◽  
Author(s):  
Marco Volante ◽  
Ozgur Mete ◽  
Giuseppe Pelosi ◽  
Anja C. Roden ◽  
Ernst Jan M. Speel ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Young Patients ◽  
Carcinoid Tumors ◽  
Neuroendocrine Neoplasms ◽  
Grey Zone ◽  
Cell Hyperplasia ◽  
Ki 67 ◽  
Familial Form ◽  
Well Differentiated ◽  
Neuroendocrine Carcinomas

AbstractThoracic (pulmonary and thymic) neuroendocrine tumors are well-differentiated epithelial neuroendocrine neoplasms that are classified into typical and atypical carcinoid tumors based on mitotic index cut offs and presence or absence of necrosis. This classification scheme is of great prognostic value but designed for surgical specimens, only. Deep molecular characterization of thoracic neuroendocrine tumors highlighted their difference with neuroendocrine carcinomas. Neuroendocrine tumors of the lung are characterized by a low mutational burden, and a high prevalence of mutations in chromatin remodeling and histone modification-related genes, whereas mutations in genes frequently altered in neuroendocrine carcinomas are rare. Molecular profiling divided thymic neuroendocrine tumors into three clusters with distinct clinical outcomes and characterized by a different average of copy number instability. Moreover, integrated histopathological, molecular and clinical evidence supports the existence of a grey zone category between neuroendocrine tumors (carcinoid tumors) and neuroendocrine carcinomas. Indeed, cases with well differentiated morphology but mitotic/Ki-67 indexes close to neuroendocrine carcinomas have been increasingly recognized. These are characterized by specific molecular profiles and have an aggressive clinical behavior. Finally, thoracic neuroendocrine tumors may arise in the background of genetic susceptibility, being MEN1 syndrome the well-defined familial form. However, pathologists should be aware of rarer germline variants that are associated with the concurrence of neuroendocrine tumors of the lung or their precursors (such as DIPNECH) with other neoplasms, including but not limited to breast carcinomas. Therefore, genetic counseling for all young patients with thoracic neuroendocrine neoplasia and/or any patient with pathological evidence of neuroendocrine cell hyperplasia-to-neoplasia progression sequence or multifocal disease should be considered.

scholarly journals Laryngeal Neuroendocrine Carcinomas: A Retrospective Study of 14 Cases

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Yingying Zhu ◽  
Liming Gao ◽  
Yunxiao Meng ◽  
Wenwen Diao ◽  
Xiaoli Zhu ◽  
...  
Keyword(s):  
Survival Time ◽  
Neuroendocrine Carcinoma ◽  
Clinical Manifestations ◽  
Small Cell ◽  
Atypical Carcinoid ◽  
Small Cell Neuroendocrine Carcinoma ◽  
Typical Carcinoid ◽  
Mean Survival Time ◽  
The Mean ◽  
Neuroendocrine Carcinomas

Laryngeal neuroendocrine carcinomas (LNECs) are rare and highly heterogeneous which present a wide spectrum of pathological and clinical manifestations. Fourteen patients with histologically demonstrated LNEC were collected and analyzed retrospectively. The 14 cases were classified into 3 subtypes: typical carcinoid in 2, atypical carcinoid in 5, and small cell neuroendocrine carcinoma in 7. The mean survival time of the 14 patients in this study was 112.5 months (95% CI, 81.5–143.6). Surgeries were performed for 2 patients of typical carcinoid, and they were alive with no evidence of recurrence after 24 and 47 months of follow-ups. Patients in the atypical carcinoid group were treated with surgeries and postoperative radiotherapy. After 58.4 months of follow-ups (range: 9–144), 2 patients showed no evidence of disease and 1 was lost to follow-up after 72 months. The other 2 patients died of other unrelated diseases. In the small cell neuroendocrine carcinoma group, a combination of chemotherapy and radiotherapy was applied. The mean survival time was 79.7 months (95% CI, 37.9–121.4), and the 5-year survival rate was 53.6%. In conclusion, the clinical behaviors, treatment protocols, and prognosis are different for each subtype of LNECs.

Diffuse Idiopathic Neuroendocrine Cell Hyperplasia, Tumorlets and Typical Carcinoid Tumors

2016 ◽  
Vol 52 (12) ◽  
pp. 623-625
Author(s):  
Jorge Lima Álvarez ◽  
Javier Muñoz Gutiérrez ◽  
Antonio J. Cruz Medina ◽  
Nuria Reyes Núñez ◽  
Enrique Rodríguez Zarco
Keyword(s):  
Carcinoid Tumors ◽  
Neuroendocrine Cell ◽  
Cell Hyperplasia ◽  
Typical Carcinoid
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