Efficacy of 67Ga-Scintigraphy in Predicting the Diagnostic Yield of Transbronchial Lung Biopsy in Pulmonary Sarcoidosis

CHEST Journal ◽  
1982 ◽  
Vol 82 (1) ◽  
pp. 7-9 ◽  
Author(s):  
Richard S. Ackart ◽  
Thomas L. Munzel ◽  
James J. Rodriguez ◽  
Charles J. Donlan ◽  
Ronald J. Klayton ◽  
...  
Keyword(s):  
Lung Biopsy ◽  
Diagnostic Yield ◽  
Pulmonary Sarcoidosis ◽  
Transbronchial Lung Biopsy ◽  
67Ga Scintigraphy

scholarly journals Factors associated with the diagnostic yield of computed tomography-guided transbronchial lung biopsy

2017 ◽  
Vol 8 (3) ◽  
pp. 153-158 ◽  
Author(s):  
Seon Cheol Park ◽  
Cheong Ju Kim ◽  
Chang Hoon Han ◽  
Sun Min Lee
Keyword(s):  
Computed Tomography ◽  
Lung Biopsy ◽  
Diagnostic Yield ◽  
Transbronchial Lung Biopsy ◽  
Factors Associated

scholarly journals Diagnostic Value of Transbronchial Lung Biopsy: Including Diagnostic Yield According to Tumor-bronchus Relationship

2000 ◽  
Vol 48 (4) ◽  
pp. 438
Author(s):  
Tae Kyong Kang ◽  
Seung Lck Cha ◽  
Jae Yong Park ◽  
Sang Chul Chae ◽  
Chang Ho Kim ◽  
...  
Keyword(s):  
Lung Biopsy ◽  
Diagnostic Yield ◽  
Diagnostic Value ◽  
Transbronchial Lung Biopsy

Transbronchial Lung Biopsy in Pulmonary Sarcoidosis

CHEST Journal ◽  
1986 ◽  
Vol 89 (3) ◽  
pp. 361-365 ◽  
Author(s):  
Venerino Poletti ◽  
Marco Patelli ◽  
Luigi Spiga ◽  
Romano Ferracini ◽  
Valeria Manetto
Keyword(s):  
Lung Biopsy ◽  
Pulmonary Sarcoidosis ◽  
Transbronchial Lung Biopsy

scholarly journals Diagnostic Value of Virtual Bronchoscopic Navigation Combined With Endobronchial Ultrasound Guided Transbronchial Lung Biopsy for Peripheral Pulmonary Lesions

2021 ◽  
Vol 20 ◽  
pp. 153303382198999
Author(s):  
Chunhua Xu ◽  
Yan Wang ◽  
Li Li ◽  
Qi Yuan ◽  
Yuchao Wang ◽  
...  
Keyword(s):  
Lung Biopsy ◽  
Diagnostic Yield ◽  
Operation Time ◽  
Transbronchial Lung Biopsy ◽  
Endobronchial Ultrasound ◽  
Ultrasound Guided ◽  
Pulmonary Lesions ◽  
X Ray ◽  
Significant Difference ◽  
Peripheral Pulmonary Lesions

Objective: X-ray guided transbronchial ultrasound-guided transbronchial lung biopsy (EBUS-TBLB) can improve the diagnostic yield of peripheral pulmonary lesions (PPLs), but it needs special requirements. The purpose of this study was to investigate the clinical value of virtual bronchoscopy navigation (VBN) combined with EBUS-TBLB in the diagnosis of PPLs without X-ray guidance. Methods: The 105 patients with PPLs underwent EBUS-TBLB with or without VBN randomly. The diagnostic yield, the operation time and complications were evaluated in the 2 groups. Results: No significant difference was found between the VBN+EBUS group and the EBUS group (76.0% vs. 65.5%, P = 0.287). The operation time of VBN+EBUS group was significantly shorter than that of EBUS group (20.6 ± 12.8 min vs. 28.6 ± 14.3 min, P = 0.023). No severe procedure related complications occurred. Conclusions: VBN can shorten the operation time. The combination of VBN and EBUS-TBLB is a safe and effective diagnosis technique for PPLs.

scholarly journals Diagnostic Yield, Safety and Impact of Transbronchial Lung Biopsy in Mechanically Ventilated Critically Ill Patients: A Retrospective Study

2020 ◽  
Author(s):  
Alessandro Ghiani ◽  
Claus Neurohr
Keyword(s):  
Mechanical Ventilation ◽  
Adverse Events ◽  
Hospital Mortality ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Lung Biopsy ◽  
Diagnostic Yield ◽  
Transbronchial Lung Biopsy ◽  
Mechanically Ventilated ◽  
Surgical Lung Biopsy

Abstract BackgroundPulmonary infiltrates of variable etiology are one of the main reasons for hypoxemic respiratory failure leading to invasive mechanical ventilation. If pulmonary infiltrates remain unexplained or progress despite treatment, the histopathological result of a lung biopsy could have significant impact on change in therapy. Surgical lung biopsy is the commonly used technique, but due to its considerable morbidity and mortality, less invasive bronchoscopic transbronchial lung biopsy (TBLB) may be a valuable alternative.MethodsRetrospective, monocentric, observational study in mechanically ventilated, critically ill patients, subjected to TBLB due to unexplained pulmonary infiltrates in the period January 2014 to July 2019. Patients` medical records were reviewed to obtain data on baseline clinical characteristics, modality and adverse events (AE) of the TBLB, and impact of the histopathological results on change in therapy. A multivariable binary logistic regression analysis was performed to identify predictors of AE and hospital mortality, and survival curves were generated using the Kaplan-Meier method.ResultsForty-two patients with in total 42 TBLB procedures after a median of 12 days of mechanical ventilation were analyzed, of which 16.7% were immunosuppressed, but there was no patient with prior lung transplantation. Diagnostic yield of the TBLB was 88.1%, with AE occurring in 11.9% (most common pneumothorax and minor bleeding). 92.9% of the procedures were performed as a forceps biopsy, with organizing pneumonia (OP) being the most common histological diagnosis (54.8%). Variables independently associated with hospital mortality were age (odds ratio 1.070, 95%CI 1.006–1.138; p = 0.031) and the presence of OP (0.182, [0.036–0.926]; p = 0.040), the latter being confirmed in the survival analysis (log-rank p = 0.040). In contrast, a change in therapy based on histopathology alone occurred in only 40.5%, and there was no evidence of a survival benefit in those patients.ConclusionsTransbronchial lung biopsy remains a valuable alternative to surgical lung biopsy in mechanically ventilated critically ill patients. However, the high diagnostic yield must be weighed against potential adverse events and limited consequence of the histological result regarding treatment decisions in such patients.

scholarly journals The value of transbronchial lung biopsy using jumbo forceps via rigid bronchoscope in diffuse lung disease

2016 ◽  
Vol 69 (2) ◽  
Author(s):  
G.L. Casoni ◽  
C. Gurioli ◽  
P.N. Chhajed ◽  
M. Chilosi ◽  
M. Zompatori ◽  
...  
Keyword(s):  
Lung Disease ◽  
Lung Biopsy ◽  
Diagnostic Yield ◽  
Random Sequence ◽  
Lung Nodule ◽  
Rigid Bronchoscopy ◽  
Transbronchial Lung Biopsy ◽  
Rigid Bronchoscope ◽  
Diffuse Parenchymal Lung Disease ◽  
Diffuse Lung

Background. Transbronchial lung biopsy (TBLB) is a valuable procedure used to obtain a parenchymal specimen in the evaluation of diffuse lung infiltrates. Large forceps are expected to result in larger specimens and improve diagnostic yield. Aim. The objective of this study was to evaluate diagnostic yield of TBLB using large modified flexible gastroenterological forceps (“Jumbo forceps”) compared with ‘normal’ flexible forceps via rigid bronchoscopy in patients with diffuse parenchymal lung disease (DPLD). Methods. The study was a prospective analysis of 95 patients who underwent fluoroscopy guided TBLB over a two year period. Patients with a lung mass or solitary lung nodule undergoing TBLB were excluded. The larger and small forceps were used in a random sequence to avoid a reduction in diagnostic yield of the second series of biopsies related to possible bleeding by first series of biopsies. To minimize the consequence of haemorrhage, we performed every rigid bronchoscopy, placing a non inflated Fogarty balloon and a rigid aspirator (diameter 4 mm) in lobar bronchus near the biopsy segment. The Fogarty balloon has been inflated in case of bleeding. After the bleeding was controlled we continued to operate up to the biopsy segment. Results. Diagnostic yield of TBLB using Jumbo forceps was significantly higher than using normal flexible forceps via rigid bronchoscopy in patients with DPLD (p=0.001). In 74 out of 95 patients (78%) the diagnosis was placed with Jumbo forcep while the smaller forcep was diagnostic in 62 out of 95 patients (65%). Large forceps obtained significantly more tissue than the small forceps; the biopsy specimen taken with normal forcep measured in average 1.4 x 1.0 mm and the larger biopsy taken with jumbo forcep measured in average 2.5 x 1.9 mm (p < 0.005). Conclusion. The use of large biopsy forceps to perform TBLB via rigid bronchoscope can significantly increase diagnostic yield in the pathological diagnosis of diffuse infiltrative lung disease.

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