Profound Hypoglycemia With MDMA (Ecstasy) Intoxication

CHEST Journal ◽  
2014 ◽  
Vol 146 (4) ◽  
pp. 325A
Author(s):  
Perliveh Carrera ◽  
Sarah Lee ◽  
Vivek Iyer
Keyword(s):  
Ecstasy Intoxication

scholarly journals Profound Hypoglycemia with Ecstasy Intoxication

2015 ◽  
Vol 2015 ◽  
pp. 1-2 ◽  
Author(s):  
Perliveh Carrera ◽  
Vivek N. Iyer
Keyword(s):  
Early Recognition ◽  
Serum Insulin ◽  
Severe Hypoglycemia ◽  
Altered Mental Status ◽  
High Dose ◽  
Psychomotor Agitation ◽  
Hemodynamic Compromise ◽  
Frequent Monitoring ◽  
Ecstasy Intoxication ◽  
Synthetic Drug

Background.3,4-Methylenedioxymethamphetamine (MDMA) or ecstasy is a synthetic drug that is commonly abused for its stimulant and euphoric effects. Adverse MDMA effects include hyperthermia, psychomotor agitation, hemodynamic compromise, renal failure, hyponatremia, and coma. However, endogenous hyperinsulinemia with severe persistent hypoglycemia has not been reported with MDMA use.Case Report.We report the case of a 29-year-old woman who remained severely hypoglycemic requiring continuous intravenous infusion of high-dose dextrose solutions for more than 24 hours after MDMA intoxication. Serum insulin and C-peptide levels confirmed marked endogenous hyperinsulinemia as the cause of the severe hypoglycemia.Why Should an Emergency Physician Be Aware of This?Immediate and frequent monitoring of blood glucose should be instituted in patients presenting with MDMA ingestion particularly if found to be initially hypoglycemic. Early recognition can help prevent the deleterious effects of untreated hypoglycemia that can add to the morbidity from MDMA use. Clinicians need to be aware of this side effect of MDMA so they can carefully monitor and treat it, especially in patients presenting with altered mental status.

scholarly journals Ecstasy intoxication: the toxicological basis for treatment

2003 ◽  
Vol 58 (6) ◽  
pp. 332-341 ◽  
Author(s):  
Maristela Ferigolo ◽  
Adriana G. da S. Machado ◽  
Niara B. Oliveira ◽  
Helena M. T. Barros
Keyword(s):  
Health Care Providers ◽  
Adverse Reactions ◽  
Oral Route ◽  
Acute Intoxication ◽  
Care Providers ◽  
Neurotoxic Effects ◽  
Ecstasy Intoxication ◽  
The Central Nervous System ◽  
Dose Dependent Increase ◽  
Dose Dependent

Youngsters are increasingly using 3,4 methylenedioxymethamphetamine, known as ecstasy, because it is wrongly believed that it does not induce harm. However, there are many reports of adverse effects, including acute intoxication, abuse potential, and possible neurotoxic effects. Therefore, health care providers need to promptly recognize the symptoms of systemic intoxication in order to initiate early treatment. The drug is used by the oral route for long hours during crowded dance parties. Acutely, ecstasy increases the release of serotonin and decreases its reuptake, leading to hypertension, hyperthermia, trismus, and vomiting. There is debate on whether recreational doses of ecstasy cause permanent damage to human serotonergic neurons. Ecstasy users showed a high risk of developing psychopathological disturbances. The prolonged use of ecstasy might induce dependence, characterized by tolerance and hangover. Acute ecstasy intoxication needs emergency-type treatment to avoid the dose-dependent increase in adverse reactions and in severity of complications. There are no specific antidotes to be used during acute intoxication. Supportive measures and medical treatment for each one of the complications should be implemented, keeping in mind that symptoms originate mainly from the central nervous system and the cardiovascular system.

scholarly journals Cardiac Arrest After Status Epilepticus: Bupropion and Ecstasy Intoxication

2018 ◽  
Vol 16 (1) ◽  
pp. 41-43
Author(s):  
Zübeyde Tuba Duran ◽  
Pınar Karabacak ◽  
Kemal Yetiş Gülsoy ◽  
Hatice Akdu ◽  
Füsun Eroğlu
Keyword(s):  
Cardiac Arrest ◽  
Status Epilepticus ◽  
Ecstasy Intoxication

Ecstasy intoxication as an unusual cause of epileptic seizures in young children

2013 ◽  
Vol 172 (11) ◽  
pp. 1547-1550 ◽  
Author(s):  
Steven Pauwels ◽  
Francis Lemmens ◽  
Kim Eerdekens ◽  
Joris Penders ◽  
Koen Poesen ◽  
...  
Keyword(s):  
Young Children ◽  
Epileptic Seizures ◽  
Ecstasy Intoxication

scholarly journals Hemoadsorption to treat severe iatrogenic intoxication with Patent Blue: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Fabio Silvio Taccone ◽  
Mickael Gardette ◽  
Jacques Creteur ◽  
Alexandre Brasseur ◽  
Sophie Lorent ◽  
...  
Keyword(s):  
Case Report ◽  
Metabolic Acidosis ◽  
Organ Failure ◽  
Multiple Organ ◽  
Asian Woman ◽  
Patent Blue ◽  
First Case ◽  
Ecstasy Intoxication ◽  
Patent Blue V ◽  
Lactate Levels

Abstract Background Intoxication with Patent Blue V [sodium compound of (diethylamino-4-phenyl)(hydroxy-5-disulfo-2,4-phenyl) methanol] can lead to high levels of methemoglobin and metabolic acidosis. In severe cases and if not rapidly eliminated from the plasma, this can lead to multiple organ failure and death. Case report A 27-year-old Asian woman (original from Vietnam) was admitted after ecstasy intoxication resulting in multi-organ failure (acute respiratory distress syndrome, metabolic acidosis, capillary leakage syndrome, renal failure, shock refractory to standard resuscitation). As a consequence, continuous renal replacement therapy and veno-venous extracorporeal membrane oxygenation were started. Methylene blue administration to reverse vasoplegia was decided, but unfortunately, Patent Blue V was erroneously administered, resulting in a severe clinical picture of methemoglobinemia and tissue hypoxia. As a therapeutic intervention, CytoSorb hemoadsorption was initiated, and rapid and significant reduction in plasma methemoglobin, accompanied by improved hemodynamics and normalization in plasma lactate levels, was observed. Conclusions This is the first case describing the application of CytoSorb hemoadsorption in a patient with ecstasy intoxication complicated by iatrogenic administration of Patent Blue V. There is a potential role for CytoSorb in drug intoxication, which needs to be confirmed in larger series.

scholarly journals Involvement of Inferior Parietal Lobules in Prospective Memory Impairment during Acute MDMA (Ecstasy) Intoxication: An Event-Related fMRI Study

2008 ◽  
Vol 34 (7) ◽  
pp. 1641-1648 ◽  
Author(s):  
Johannes G Ramaekers ◽  
Kim P C Kuypers ◽  
Marleen Wingen ◽  
Armin Heinecke ◽  
Elia Formisano
Keyword(s):  
Prospective Memory ◽  
Memory Impairment ◽  
Fmri Study ◽  
Ecstasy Intoxication ◽  
Prospective Memory Impairment

Recovery After Ecstasy Intoxication

1999 ◽  
Vol 37 (3) ◽  
pp. 341-341 ◽  
Author(s):  
Joseph G. Rella ◽  
Lewis S. Nelson
Keyword(s):  
Ecstasy Intoxication
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