Serum Procalcitonin and C-Reactive Protein Levels as Indicators of Treatment Success in Patients With Community-Acquired Pneumonia

CHEST Journal ◽  
2014 ◽  
Vol 146 (4) ◽  
pp. 920A
Author(s):  
Abdullah Sayiner ◽  
M. Sezai Tasbakan ◽  
Canan Gunduz ◽  
Aykut Cilli ◽  
Burcu Celenk ◽  
...  
Keyword(s):  
Treatment Success ◽  
Community Acquired Pneumonia ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

scholarly journals Association of serum procalcitonin and C-reactive protein levels with CURB-65 criteria among patients with community-acquired pneumonia

2018 ◽  
Vol Volume 11 ◽  
pp. 217-223 ◽  
Author(s):  
Fariba Keramat ◽  
Hamid Reza Ghasemi Basir ◽  
Elham Abdoli ◽  
Arghavan Shafiee Aghdam ◽  
Jalal Poorolajal
Keyword(s):  
Community Acquired Pneumonia ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

scholarly journals Role of Plasma Presepsin, Procalcitonin and C-reactive Protein Levels in Determining the Severity and Mortality of Community-Acquired Pneumonia in the Emergency Department

2020 ◽  
Keyword(s):  
Emergency Department ◽  
Community Acquired Pneumonia ◽  
C Reactive Protein ◽  
Pneumonia Severity ◽  
Protein Levels ◽  
Reactive Protein ◽  
Imaging Results ◽  
Severity Scores ◽  
Significant Difference

Objective: In this study, we aimed to explore the role of the plasma presepsin level in patients with community-acquired pneumonia during admission to the emergency department in assessing the diagnosis, severity, and prognosis of the disease. In addition, we wanted to investigate the relationship of presepsinin with procalcitonin, C-reactive protein and pneumonia severity scores. Methods: One hundred twenty-three patients over the age of 18 who presented with a diagnosis of pneumonia to the emergency department were included in the study. The vital signs, symptoms, examination findings, background information, laboratory results, and radiological imaging results of the patients were recorded. The 30-day mortality rates of the patients were determined. Results: A statistically significant difference was found between the presepsin levels of the patients diagnosed with pneumonia and those of healthy subjects (p < 0.05). The plasma presepsin levels of the patients who died (8.63 ± 6.46) were significantly higher than those of the patients who lived (5.82 ± 5.97) (p < 0.05). The plasma procalcitonin and C-reactive protein levels of the dead patients were significantly higher than those living (p < 0.05). A presepsin cut-off value of 3.3 ng/mL for 30-day mortality was established (AUROC, 0.65; specificity, 45%; sensitivity, 82%). Procalcitonin is the most successful biomarker in the determination of mortality (AUROC, 0.70). A significant correlation was available between presepsin and lactate, C-reactive protein and procalcitonin (p < 0.05). There was a significant correlation between the Pneumonia Severity Index values and presepsin levels (p < 0.001, r = 0.311). Conclusion: The plasma presepsin level can be utilized for diagnosing community-acquired pneumonia. Plasma presepsin, procalcitonin and C-reactive protein levels can be used to predict the severity and mortality of community-acquired pneumonia.

Oral Antibiotics for Treating Children With Community-Acquired Pneumonia Complicated by Empyema

2019 ◽  
Vol 58 (13) ◽  
pp. 1401-1408 ◽  
Author(s):  
Lauren E. Kushner ◽  
Delma J. Nieves ◽  
Stephanie Osborne ◽  
Hita Vora ◽  
Antonio Arrieta ◽  
...  
Keyword(s):  
Primary Outcome ◽  
Treatment Success ◽  
Community Acquired Pneumonia ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Length Of Treatment ◽  
Erythrocyte Sedimentation ◽  
End Of Treatment ◽  
Wbc Count ◽  
Serial Measurements

No consensus exists on management of children with community-acquired pneumonia complicated by empyema (CAP-Em). We evaluated outpatient oral (O-Abx) compared with parenteral antibiotics (OPAT) in children with CAP-Em. We also evaluated inflammatory markers to guide length of treatment. We conducted a retrospective cohort study of patients discharged (2006-2016) with CAP-Em. Primary outcome measured was treatment success (no change in antibiotics or readmission to hospital for treatment of CAP-Em). White blood cell (WBC) count, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) serial measurements were identified. Success was achieved in 133/144 (92.4%) O-Abx and 7/12 (58%) OPAT patients ( P = .0031). WBC and CRP decreased early; and ESR increased initially (admit and switch to O-Abx) and decreased by end of treatment. O-Abx is the modality of choice for treatment of CAP-Em after hospital discharge. WBC and CRP are useful to monitor success of O-Abx switch; and ESR provides guidance for length of treatment.

scholarly journals C-reactive protein levels in community-acquired pneumonia

2003 ◽  
Vol 21 (4) ◽  
pp. 702-705 ◽  
Author(s):  
E. García Vázquez ◽  
J.A. Martínez ◽  
J. Mensa ◽  
F. Sánchez ◽  
M.A. Marcos ◽  
...  
Keyword(s):  
Community Acquired Pneumonia ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

scholarly journals Burden of Respiratory Syncytial Virus Associated Severe Pneumonia in Hospitalized Children

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Madhusha Gonapaladeniya ◽  
Thushari Dissanayake ◽  
Guwani Liyanage
Keyword(s):  
Respiratory Syncytial Virus ◽  
Respiratory Infections ◽  
Tertiary Care ◽  
Severe Pneumonia ◽  
Community Acquired Pneumonia ◽  
Hospitalized Children ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Syncytial Virus

Respiratory syncytial virus (RSV) is a leading cause of severe respiratory infections. We examined the burden of RSV-associated severe community-acquired pneumonia among hospitalized children and factors that predict RSV etiology. A hospital-based prospective study examined children below five years of age admitted with radiologically confirmed severe or very severe pneumonia in two tertiary care centers in Sri Lanka. Nasopharyngeal secretions (NPS) were tested for 19 viruses by multiplex RT-PCR. Univariate and multivariate analysis was performed to determine whether RSV etiology could be predicted based on clinical, sociodemographic, environmental, radiological, and laboratory parameters. A total of 108 children with severe or very severe were included in the study. At least one virus was found in NPS in 92.5% of children. Forty-six children had RSV (+) pneumonia. Mean RSV proportion was 42.6% (95% CI: 33.1-52.5%, p value = 0.149). RSV as a single virus was found in 41.3% (19/46). The children with RSV (+) pneumonia were younger ( p = 0.026 ) and had lower C-reactive protein ( p = 0.003 ) and household crowding ( p = 0.012 ) than the RSV (-) group, after controlling for confounding covariates. In conclusion, the present study demonstrated that respiratory syncytial virus was the commonest virus associated with CAP in children under five years. Younger age, crowded housing, and lower C-reactive protein levels were predictors of severe RSV-associated pneumonia.

Positive correlation between neovascularization degree of carotid atherosclerosis determined by contrast-enhanced ultrasound and level of serum C-reactive protein

VASA ◽  
2015 ◽  
Vol 44 (3) ◽  
pp. 0187-0194 ◽  
Author(s):  
Xiaoni Chang ◽  
Jun Feng ◽  
Litao Ruan ◽  
Jing Shang ◽  
Yanqiu Yang ◽  
...  
Keyword(s):  
Contrast Enhancement ◽  
Rank Correlation ◽  
Artery Stenosis ◽  
Contrast Enhanced Ultrasound ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Contrast Enhanced ◽  
Grade 3 ◽  
Axis View

Background: Neovascularization is one of the most important risk factors for unstable plaque. This study was designed to correlate plaque thickness, artery stenosis and levels of serum C-reactive protein with the degree of intraplaque enhancement determined by contrast-enhanced ultrasound. Patients and methods: Contrast-enhanced ultrasound was performed on 72 carotid atherosclerotic plaques in 48 patients. Contrast enhancement within the plaque was categorized as grade 1, 2 or 3. Maximum plaque thickness was measured in short-axis view. Carotid artery stenosis was categorized as mild, moderate or severe. Results: Plaque contrast enhancement was not associated with the degree of artery stenosis or with plaque thickness. Serum C-reactive protein levels were positively correlated with the number of new vessels in the plaque. C-reactive protein levels increased in the three groups(Grade 1: 3.72±1.79mg/L; Grade 2: 7.88±4.24 mg/L; Grade 3: 11.02±3.52 mg/L), with significant differences among them (F=10.14, P<0.01), and significant differences between each two groups (P<0.05). Spearman’s rank correlation analysis showed that serum C-reactive protein levels were positively correlated with the degree of carotid plaque enhancement (Rs =0.69, P<0.01). Conclusions: The combination of C-reactive protein levels and intraplaque neovascularization detected by contrast-enhanced ultrasound may allow more accurate evaluation of plaque stability.

Sign in / Sign up

Export Citation Format

Share Document