scholarly journals Burden of Respiratory Syncytial Virus Associated Severe Pneumonia in Hospitalized Children

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Madhusha Gonapaladeniya ◽  
Thushari Dissanayake ◽  
Guwani Liyanage
Keyword(s):  
Respiratory Syncytial Virus ◽  
Respiratory Infections ◽  
Tertiary Care ◽  
Severe Pneumonia ◽  
Community Acquired Pneumonia ◽  
Hospitalized Children ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Syncytial Virus

Respiratory syncytial virus (RSV) is a leading cause of severe respiratory infections. We examined the burden of RSV-associated severe community-acquired pneumonia among hospitalized children and factors that predict RSV etiology. A hospital-based prospective study examined children below five years of age admitted with radiologically confirmed severe or very severe pneumonia in two tertiary care centers in Sri Lanka. Nasopharyngeal secretions (NPS) were tested for 19 viruses by multiplex RT-PCR. Univariate and multivariate analysis was performed to determine whether RSV etiology could be predicted based on clinical, sociodemographic, environmental, radiological, and laboratory parameters. A total of 108 children with severe or very severe were included in the study. At least one virus was found in NPS in 92.5% of children. Forty-six children had RSV (+) pneumonia. Mean RSV proportion was 42.6% (95% CI: 33.1-52.5%, p value = 0.149). RSV as a single virus was found in 41.3% (19/46). The children with RSV (+) pneumonia were younger ( p = 0.026 ) and had lower C-reactive protein ( p = 0.003 ) and household crowding ( p = 0.012 ) than the RSV (-) group, after controlling for confounding covariates. In conclusion, the present study demonstrated that respiratory syncytial virus was the commonest virus associated with CAP in children under five years. Younger age, crowded housing, and lower C-reactive protein levels were predictors of severe RSV-associated pneumonia.

scholarly journals Association of serum procalcitonin and C-reactive protein levels with CURB-65 criteria among patients with community-acquired pneumonia

2018 ◽  
Vol Volume 11 ◽  
pp. 217-223 ◽  
Author(s):  
Fariba Keramat ◽  
Hamid Reza Ghasemi Basir ◽  
Elham Abdoli ◽  
Arghavan Shafiee Aghdam ◽  
Jalal Poorolajal
Keyword(s):  
Community Acquired Pneumonia ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

scholarly journals Serum C-reactive protein levels in severe and very severe pneumonia in children

2012 ◽  
Vol 52 (3) ◽  
pp. 161-164
Author(s):  
Ni Putu Sucita Wahyu Dewi ◽  
Putu Siadi Purniti ◽  
Roni Naning
Keyword(s):  
Severe Pneumonia ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

scholarly journals Role of Plasma Presepsin, Procalcitonin and C-reactive Protein Levels in Determining the Severity and Mortality of Community-Acquired Pneumonia in the Emergency Department

2020 ◽  
Keyword(s):  
Emergency Department ◽  
Community Acquired Pneumonia ◽  
C Reactive Protein ◽  
Pneumonia Severity ◽  
Protein Levels ◽  
Reactive Protein ◽  
Imaging Results ◽  
Severity Scores ◽  
Significant Difference

Objective: In this study, we aimed to explore the role of the plasma presepsin level in patients with community-acquired pneumonia during admission to the emergency department in assessing the diagnosis, severity, and prognosis of the disease. In addition, we wanted to investigate the relationship of presepsinin with procalcitonin, C-reactive protein and pneumonia severity scores. Methods: One hundred twenty-three patients over the age of 18 who presented with a diagnosis of pneumonia to the emergency department were included in the study. The vital signs, symptoms, examination findings, background information, laboratory results, and radiological imaging results of the patients were recorded. The 30-day mortality rates of the patients were determined. Results: A statistically significant difference was found between the presepsin levels of the patients diagnosed with pneumonia and those of healthy subjects (p < 0.05). The plasma presepsin levels of the patients who died (8.63 ± 6.46) were significantly higher than those of the patients who lived (5.82 ± 5.97) (p < 0.05). The plasma procalcitonin and C-reactive protein levels of the dead patients were significantly higher than those living (p < 0.05). A presepsin cut-off value of 3.3 ng/mL for 30-day mortality was established (AUROC, 0.65; specificity, 45%; sensitivity, 82%). Procalcitonin is the most successful biomarker in the determination of mortality (AUROC, 0.70). A significant correlation was available between presepsin and lactate, C-reactive protein and procalcitonin (p < 0.05). There was a significant correlation between the Pneumonia Severity Index values and presepsin levels (p < 0.001, r = 0.311). Conclusion: The plasma presepsin level can be utilized for diagnosing community-acquired pneumonia. Plasma presepsin, procalcitonin and C-reactive protein levels can be used to predict the severity and mortality of community-acquired pneumonia.

Survey of WU and KI polyomaviruses, coronaviruses, respiratory syncytial virus and parechovirus in children under 5 years of age in Tehran, Iran

2020 ◽  
Author(s):  
Fahimeh Sadat Aghamirmohammadali ◽  
Kaveh Sadeghi ◽  
Nazanin Zahra Shafiei-Jandaghi ◽  
Zahra Khoban ◽  
Talat Mokhtari-Azad ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Respiratory Infections ◽  
Virus Detection ◽  
Respiratory Viruses ◽  
Hospitalized Children ◽  
Acute Respiratory Infections ◽  
Older Children ◽  
Viral Pathogen ◽  
Syncytial Virus ◽  
Tract Infections

Background and Objectives: Severe acute respiratory infections (SARI) remain an important cause for childhood morbid- ity worldwide. We designed a research with the objective of finding the frequency of respiratory viruses, particularly WU and KI polyomaviruses (WUPyV & KIPyV), human coronaviruses (HCoVs), human respiratory syncytial virus (HRSV) and human parechovirus (HPeV) in hospitalized children who were influenza negative. Materials and Methods: Throat swabs were collected from children younger than 5 years who have been hospitalized for SARI and screened for WUPyV, KIPyV, HCoVs, HRSV and HPeV using Real time PCR. Results: A viral pathogen was identified in 23 (11.16%) of 206 hospitalized children with SARI. The rate of virus detection was considerably greater in infants <12 months (78.2%) than in older children (21.8%). The most frequently detected vi- ruses were HCoVs with 7.76% of positive cases followed by KIPyV (2%) and WUPyV (1.5%). No HPeV and HRSV were detected in this study. Conclusion: This research shown respiratory viruses as causes of childhood acute respiratory infections, while as most of mentioned viruses usually causes mild respiratory diseases, their frequency might be higher in outpatient children. Mean- while as HRSV is really sensitive to inactivation due to environmental situations and its genome maybe degraded, then for future studies, we need to use fresh samples for HRSV detection. These findings addressed a need for more studies on viral respiratory tract infections to help public health.

Serum Procalcitonin and C-Reactive Protein Levels as Indicators of Treatment Success in Patients With Community-Acquired Pneumonia

CHEST Journal ◽  
2014 ◽  
Vol 146 (4) ◽  
pp. 920A
Author(s):  
Abdullah Sayiner ◽  
M. Sezai Tasbakan ◽  
Canan Gunduz ◽  
Aykut Cilli ◽  
Burcu Celenk ◽  
...  
Keyword(s):  
Treatment Success ◽  
Community Acquired Pneumonia ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

scholarly journals Is there any relationship between C-reactive protein/albumin ratio and clinical severity of childhood community-acquired pneumonia

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Hayrunnisa Bekis Bozkurt
Keyword(s):  
Severe Pneumonia ◽  
Multivariate Regression Analysis ◽  
Blood Parameters ◽  
Community Acquired Pneumonia ◽  
Clinical Severity ◽  
Control Group ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Albumin Ratio ◽  
Reactive Protein

Abstract Objectives To investigate the relationship between the ratios of C-reactive protein (CRP)/albumin, neutrophil/lymphocyte (NLR), monocyte/lymphocyte (MLR), mean platelet volume (MPV)/platelet and erythrocyte sedimentation rate (ESR)/albumin in pediatric patients diagnosed with community-acquired pneumonia based on the severity of the disease. Methods This retrospective cross-sectional study included 52 patients with mild pneumonia, 30 with severe pneumonia, and 46 healthy controls. Whole blood parameters, CRP, ESR, and albumin values and ratios were recorded at the time of admission. The multivariate regression analysis, Pearson’s correlation and ROC curve analyses were performed. Results The CRP/albumin, ESR/albumin, NLR and CRP values were significantly higher in the severe pneumonia group compared to both the other pneumonia group and the control group (p<0.005). According to the regression and correlation analyses, these values were positively correlated (p<0.001). For CRP/Albumin ratio, ESR/albumin ratio calculated OR were 2.103 (CI: 1.675–2.639); 1.907 (CI: 1.552–2.344); respectively. Conclusions The data presented can be a guide in the follow-up and treatment of this patient group.

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