Family-based Prevention of Offending: A Meta-analysis

2003 ◽  
Vol 36 (2) ◽  
pp. 127-151 ◽  
Author(s):  
David P Farrington ◽  
Brandon C Welsh
Keyword(s):  
Outcome Measure ◽  
Meta Analysis ◽  
Child Behaviour ◽  
Control Group ◽  
Costs And Benefits ◽  
Weighted Mean ◽  
The Family ◽  
Term Evaluation ◽  
Family Based

This paper presents a review and meta-analysis of the effectiveness of family-based crime prevention programs.Programs were included in this review if (a)the family was the focus of the intervention,(b)there was an outcome measure of delinquency or antisocial child behaviour, (c)the evaluation used a randomised or well controlled experiment and (d)the original sample size was at least 50 persons.Forty evaluations were found that met the criteria for inclusion.In general,these family- based programs had desirable effects in reducing delinquency (especially) and antisocial child behaviour.Over all delinquency outcomes,the weighted mean effect size of .321 corresponds approximately to a decrease in offending from 50%in a control group to 34%in an experi- mental group.Furthermore,the effects on delinquency persisted in long- term evaluation studies.The most effective types of programs used behavioural parent training,while the least effective types were those based in schools.Home visiting,day care/preschool,home/community and multi-systematic therapy programs were generally effective.Effect sizes were greater in smaller scale studies.Research on the monetary costs and benefits of family-based programs is also reviewed.

scholarly journals The Anti-PD-1/PD-L1 Immunotherapy for Gastric Esophageal Cancer: A Systematic Review and Meta-Analysis and Literature Review

2021 ◽  
Vol 28 ◽  
pp. 107327482199743
Author(s):  
Ke Chen ◽  
Xiao Wang ◽  
Liu Yang ◽  
Zheling Chen
Keyword(s):  
Overall Survival ◽  
Esophageal Cancer ◽  
Survival Rate ◽  
Meta Analysis ◽  
Response Rates ◽  
Control Group ◽  
Term Survival ◽  
Long Term Survival ◽  
And Control

Background: Treatment options for advanced gastric esophageal cancer are quite limited. Chemotherapy is unavoidable at certain stages, and research on targeted therapies has mostly failed. The advent of immunotherapy has brought hope for the treatment of advanced gastric esophageal cancer. The aim of the study was to analyze the safety of anti-PD-1/PD-L1 immunotherapy and the long-term survival of patients who were diagnosed as gastric esophageal cancer and received anti-PD-1/PD-L1 immunotherapy. Method: Studies on anti-PD-1/PD-L1 immunotherapy of advanced gastric esophageal cancer published before February 1, 2020 were searched online. The survival (e.g. 6-month overall survival, 12-month overall survival (OS), progression-free survival (PFS), objective response rates (ORR)) and adverse effects of immunotherapy were compared to that of control therapy (physician’s choice of therapy). Results: After screening 185 studies, 4 comparative cohort studies which reported the long-term survival of patients receiving immunotherapy were included. Compared to control group, the 12-month survival (OR = 1.67, 95% CI: 1.31 to 2.12, P < 0.0001) and 18-month survival (OR = 1.98, 95% CI: 1.39 to 2.81, P = 0.0001) were significantly longer in immunotherapy group. The 3-month survival rate (OR = 1.05, 95% CI: 0.36 to 3.06, P = 0.92) and 18-month survival rate (OR = 1.44, 95% CI: 0.98 to 2.12, P = 0.07) were not significantly different between immunotherapy group and control group. The ORR were not significantly different between immunotherapy group and control group (OR = 1.54, 95% CI: 0.65 to 3.66, P = 0.01). Meta-analysis pointed out that in the PD-L1 CPS ≥10 sub group population, the immunotherapy could obviously benefit the patients in tumor response rates (OR = 3.80, 95% CI: 1.89 to 7.61, P = 0.0002). Conclusion: For the treatment of advanced gastric esophageal cancer, the therapeutic efficacy of anti-PD-1/PD-L1 immunotherapy was superior to that of chemotherapy or palliative care.

scholarly journals Efficacy of a bystander intervention for preventing dating violence in Brazilian adolescents: short-term evaluation

2019 ◽  
Vol 32 (1) ◽  
Author(s):  
Karine Brito dos Santos ◽  
Sheila Giardini Murta ◽  
Luis Gustavo do Amaral Vinha ◽  
Juliana Silva de Deus
Keyword(s):  
Romantic Relationships ◽  
Dating Violence ◽  
Control Group ◽  
Short Term ◽  
Brazilian Sample ◽  
Post Test ◽  
Short Term Evaluation ◽  
Term Evaluation ◽  
Brazilian Culture

Abstract Peers are the preferred source of help for Brazilian adolescents who experience dating violence. However, they are not always the best informants for effective responses for dealing with situations of violence in romantic relationships among peers. This experimental study aimed to evaluate the short-term efficacy of three aspects of a peer- and bystander approach-based intervention: the intent to offer help, empathy, and bystander attitudes in response to dating violence in a Brazilian sample of adolescents. The study’s participants were 33 adolescents randomized in two groups: experimental group (EG, n = 14) and control group (CG, n = 19). The EG underwent three weekly intervention sessions of 90 min each on the healthy versus violent romantic relationships, the quality of friendship in the peer network, and the role of the bystander, while the CG received no intervention. Evaluations were performed 1 week before and two and half months after the intervention. Statistically significant differences between EG and CG at post-test were not found in intention to help, empathy, and bystander attitudes. Future studies should include evaluations of larger samples and mid- and long-term follow-ups to identify patterns of change over the long term as well as examine barriers to utilization of bystander behaviors by adolescents in Brazilian culture.

Very Low Birth Weight Outcomes

PEDIATRICS ◽  
1992 ◽  
Vol 89 (2) ◽  
pp. 357-357
Author(s):  
HELEN HARRISON
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Meta Analysis ◽  
Low Birth Weight Infants ◽  
Randomized Controlled Clinical Trials ◽  
Weight Outcomes ◽  
Term Evaluation

To the Editor.— The authors of the National Institute of Child Health and Human Development report on neonatal care1 found "important" variations among neonatal intensive care units in philosophies of treatment, methods of treatment, and short-term outcomes. In a recent meta-analysis of follow-up studies,2 researchers document a similarly haphazard approach to the long-term evaluation of very low birth weight survivors. Until randomized controlled clinical trials validate the safety and efficacy of neonatal therapies, and until long-term outcomes are assessed accurately, the treatment of very low birth weight infants should be declared experimental.

Gezinsprofielen, Voor- en Vroegschoolse Stimulerings-Activiteiten en Schoolsucces

2002 ◽  
Vol 68 ◽  
pp. 65-76
Author(s):  
Roel van Steensel
Keyword(s):  
Early Intervention ◽  
Primary Education ◽  
Family Characteristics ◽  
Intervention Programs ◽  
Control Group ◽  
Research Project ◽  
Educational Achievements ◽  
The Family ◽  
Family Based ◽  
At Home

In order to prepare children from disadvantaged backgrounds for primary education, early intervention programs are used. Generally, a distinction is made between two types of intervention activities: those which are conducted at home (family-based activities) and those which are conducted in, for example, preschools (center-based activities). This research project tries to establish whether there is a relation between participation in early intervention activities and the educational achievements of 119 pupils from the cities of Tilburg and Waalwijk. A comparison is made between four groups of children: a group that took part in the family-based program Opstap Opnieuw, a group that went to preschool, a group that did both, and a control group. The performances of these four groups are followed during the first years of primary education. In addition, an estimate is made of the influence of family characteristics on the effectiveness of both types of intervention activities.

Adjunctive metformin for antipsychotic-related hyperprolactinemia: A meta-analysis of randomized controlled trials

2017 ◽  
Vol 31 (5) ◽  
pp. 625-631 ◽  
Author(s):  
Wei Zheng ◽  
Xin-Hu Yang ◽  
Dong-Bin Cai ◽  
Gabor S Ungvari ◽  
Chee H Ng ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Serum Prolactin ◽  
Control Group ◽  
Controlled Trials ◽  
Large Sample Size ◽  
Weighted Mean ◽  
Randomized Controlled ◽  
Metformin Group

Hyperprolactinemia is a common and severe antipsychotic-induced adverse drug reaction. This meta-analysis of randomized controlled trials systematically examined the efficacy and safety of adjunctive metformin for antipsychotic-related hyperprolactinemia in schizophrenia patients. Two independent investigators searched, extracted, and synthesized data. Weighted mean differences and risk ratios with their 95% confidence intervals were calculated using random effect model. Four randomized controlled trials ( n=509) comparing adjunctive metformin ( n=253) with the control groups ( n=256), lasting 22.7 weeks of treatment, were included in the meta-analysis. The metformin group had significantly lower serum prolactin level at endpoint (four randomized controlled trials, n=501; weighted mean difference: −6.87 ug/L (95% confidence interval: −13.24 to −0.51), p=0.03; I2=80%) with “moderate quality” based on the grading of recommendations assessment, development, and evaluation system. In patients with menstrual disturbances, the rate of menstruation resumption was 66.7% in the metformin group and 4.8% in the control group. Adverse drug reactions and all-cause discontinuation (three randomized controlled trials, n=339, risk ratio: 0.76 (95% confidence interval: 0.29, 1.97), p=0.57; I2= 0%) were similar between the two groups. Adjunctive metformin appears to be effective and safe for reducing antipsychotic-induced hyperprolactinemia and prolactin-related symptoms in schizophrenia patients. Higher quality randomized controlled trials with a large sample size are warranted to confirm these findings.

scholarly journals Effects of Hydroxychloroquine on Proteinuria in IgA Nephropathy: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Jialing Zhang ◽  
Xiangxue Lu ◽  
Jianan Feng ◽  
Han Li ◽  
Shixiang Wang
Keyword(s):  
Systematic Review ◽  
Iga Nephropathy ◽  
Therapeutic Effect ◽  
Statistical Difference ◽  
Meta Analysis ◽  
Immunosuppressive Agents ◽  
Control Group ◽  
Percentage Reduction ◽  
And Control

Introduction. The present meta-analysis was to explore the efficacy of hydroxychloroquine (HCQ) in IgA nephropathy patients in terms of proteinuria. Method. We systematically searched PubMed and Embase for studies that compared HCQ and other treatments to reduce proteinuria in patients with IgA nephropathy up to June 2021. Mean ± SD of percentage change and level of proteinuria was calculated. Results. A total of 5 studies with 587 participants were included. IgA nephropathy patients who received HCQ were at a lower level of mean proteinuria at 6 months. However, there was no statistical difference between HCQ and control group considering percentage reduction in proteinuria. The long-term therapeutic effect of HCQ might be inferior to HCQ and renin-angiotensin-aldosterone system inhibition. Conclusion. HCQ might play a role in the reduction of proteinuria in IgA nephropathy patients. The addition of HCQ to other immunosuppressive agents should be clarified further.

Effectiveness of Aerobic Exercise on Smoking Cessation in Adults: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (2) ◽  
pp. 230-242
Author(s):  
Caroline Pereira Santos ◽  
Mahara Proença ◽  
Tamara dos Santos Gouveia ◽  
Crystian Bitencourt Soares de Oliveira ◽  
Guilherme Yassuki Tacao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Smoking Cessation ◽  
Aerobic Exercise ◽  
Usual Care ◽  
Meta Analysis ◽  
Control Group ◽  
Short Term ◽  
Continuous Abstinence ◽  
Different Characteristics

Background: The specific benefits of aerobic exercises in smoking cessation are unclear, as they have different characteristics, intensities, and durations. The purpose of this systematic review with meta-analysis was to evaluate the effects of aerobic exercise, with or without co-interventions, compared with a control group of cognitive behavior treatment on smoking cessation. Methods: This review was prospectively registered on PROSPERO, and the searches were performed from 2016 to 2018. Randomized controlled trials evaluating the effects of aerobic exercise, with or without nicotine therapy replacement, compared with usual care were included. The primary outcome was smoking cessation defined as the prevalence of those who quit or continuous abstinence. Meta-analysis was calculated using random effects model in the comprehensive meta-analysis software. Results: The authors identified 18 trials reporting data for a total of 2815 participants. There was moderate-quality evidence that aerobic exercise was better than usual care in promoting smoking cessation at short term (11 trials, risk ratio 0.79; 95% confidence interval, 0.66–0.94). However, there were no differences between aerobic exercises and usual care at medium- or long-term follow-ups. Conclusions: According to review, aerobic exercise may be effective in promoting smoking cessation at short-term, but not at medium- and long-term follow-ups.

scholarly journals Long-term evaluation of fecal continence and quality of life in patients operated for anorectal malformations

2016 ◽  
Vol 62 (6) ◽  
pp. 544-552 ◽  
Author(s):  
Ana Cristina Aoun Tannuri ◽  
Mariana Aparecida Elisei Ferreira ◽  
Arthur Loguetti Mathias ◽  
Uenis Tannuri
Keyword(s):  
Quality Of Life ◽  
Anorectal Malformations ◽  
Fecal Continence ◽  
Group Method ◽  
Control Group ◽  
Term Evaluation ◽  
Associated Malformations

Summary Introduction: Patients operated for correction of anorectal malformations (ARM) can develop fecal incontinence, constipation, and soiling, with loss in quality of life. Objective: To evaluate, through the use of questionnaires, fecal continence, and quality of life of children in the late postoperative follow-up of ARM correction, both high and low. In addition, the levels of fecal continence and quality of life were compared with those of a control group. Method: A Fecal Continence Index Questionnaire (ICF) and a Questionnaire for Assessment of Quality of Life Related to Fecal Continence in Children and Adolescents (QQVCFCA) were administered to 63 patients with ARM, aged from 7 to 19 years, whose surgical treatment had been completed for at least 6 months. The patients were compared to a control group of 59 children. Results: In the control group, 25 (42.4%) patients had good continence and 34 (57.6%), normal continence. We found that the quality of life in children with ARM is compromised globally, in all areas and in the ICF questionnaire, compared to controls (p<0.001). There was no difference between patients with high and low defects. Thirty-two (50.8%) patients had other associated anomalies. Conclusion: In patients operated for ARM correction, quality of life and ICF were compromised, and there was no difference between patients with high-type and low-type of the disease. In about half the cases there are other associated malformations.

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