scholarly journals Plasmacytoid Dendritic Cells Suppress HIV-1 Replication but Contribute to HIV-1 Induced Immunopathogenesis in Humanized Mice

2014 ◽  
Vol 10 (7) ◽  
pp. e1004291 ◽  
Author(s):  
Guangming Li ◽  
Menglan Cheng ◽  
Jun-ichi Nunoya ◽  
Liang Cheng ◽  
Haitao Guo ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Humanized Mice ◽  
Hiv 1

scholarly journals Human Plasmacytoid Dendritic Cells Efficiently Capture HIV-1 Envelope Glycoproteins via CD4 for Antigen Presentation

2013 ◽  
Vol 191 (1) ◽  
pp. 60-69 ◽  
Author(s):  
Kerrie J. Sandgren ◽  
Anna Smed-Sörensen ◽  
Mattias N. Forsell ◽  
Martina Soldemo ◽  
William C. Adams ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Antigen Presentation ◽  
Plasmacytoid Dendritic Cells ◽  
Envelope Glycoproteins ◽  
Hiv 1

scholarly journals Plasmacytoid Dendritic Cells Accumulate and Secrete Interferon Alpha in Lymph Nodes of HIV-1 Patients

PLoS ONE ◽  
2010 ◽  
Vol 5 (6) ◽  
pp. e11110 ◽  
Author(s):  
Clara Lehmann ◽  
Mark Lafferty ◽  
Alfredo Garzino-Demo ◽  
Norma Jung ◽  
Pia Hartmann ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Lymph Nodes ◽  
Interferon Alpha ◽  
Plasmacytoid Dendritic Cells ◽  
Hiv 1

HIV-1-Derived Lentiviral Vectors Directly Activate Plasmacytoid Dendritic Cells, Which in Turn Induce the Maturation of Myeloid Dendritic Cells

2011 ◽  
Vol 22 (2) ◽  
pp. 177-188 ◽  
Author(s):  
Maura Rossetti ◽  
Silvia Gregori ◽  
Ehud Hauben ◽  
Brian D. Brown ◽  
Lucia Sergi Sergi ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Lentiviral Vectors ◽  
Plasmacytoid Dendritic Cells ◽  
Myeloid Dendritic Cells ◽  
Hiv 1

scholarly journals CD4 Binding Affinity Determines Human Immunodeficiency Virus Type 1-Induced Alpha Interferon Production in Plasmacytoid Dendritic Cells

2008 ◽  
Vol 82 (17) ◽  
pp. 8900-8905 ◽  
Author(s):  
Sabrina Haupt ◽  
Norbert Donhauser ◽  
Chawaree Chaipan ◽  
Philipp Schuster ◽  
Bridget Puffer ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Dendritic Cells ◽  
Binding Affinity ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Plasmacytoid Dendritic Cells ◽  
Type I ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Plasmacytoid dendritic cells (PDC) are major producers of type I interferons (IFN) in response to human immunodeficiency virus type 1 (HIV-1) infection. To better define the underlying mechanisms, we studied the magnitude of alpha IFN (IFN-α) induction by recombinant viruses containing changes in the Env protein that impair or disrupt CD4 binding or expressing primary env alleles with differential coreceptor tropism. We found that the CD4 binding affinity but not the viral coreceptor usage is critical for the attachment of autofluorescing HIV-1 to PDC and for subsequent IFN-α induction. Our results illustrate the importance of the gp120-CD4 interaction in determining HIV-1-induced immune stimulation via IFN-α production.

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