scholarly journals Biomonitorization of concentrations of 28 elements in serum and urine among workers exposed to indium compounds

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246943
Author(s):  
Nan Liu ◽  
Yi Guan ◽  
Bin Li ◽  
Sanqiao Yao
Keyword(s):  
Occupational Exposure ◽  
Sampling Period ◽  
Systemic Circulation ◽  
The Other ◽  
Metal Exposure ◽  
Exposed Workers ◽  
Occupationally Exposed ◽  
Zinc Levels ◽  
Larger Sample ◽  
Serum And Urine

Many studies have documented the abnormal concentrations of metals/metalloids in serum or urine of occupational workers, but no works systematically analysed the concentrations of elements in serum or urine of indium-exposed workers. This study was aimed to assess 28 elements in serum and urine from 57 individuals with occupational exposure to indium and its compounds. Control subjects were 63 workers without metal exposure. We collected information on occupation and lifestyle habits by questionnaire. Biological samples were collected to quantify elements by inductive coupled plasma-mass spectrometer. Air in the breathing zones was drawn at flow rates of 1.5–3 L/min for a sampling period of 6 to 8 h, using a Model BFC-35 pump. The average ambient indium level was 0.078 mg/m3. Serum/urine Indium levels were significantly higher in indium-exposed workers than in controls (P < 0.01). Moreover, serum/urine indium concentrations in the group with 6–14 years and ≥15 years of employment were significantly higher than those with ≤5 employment years(P < 0.05). Ten of the other 27 elements/metals measured were higher in serum/urine in indium-exposed workers compared to the controls (aluminum, beryllium, cadmium, cesium, chromium, lithium, manganese, magnesium, molybdenum and vanadium). Zinc levels in serum/urine were significantly decreased in the indium-exposed workers. Additionally, other elements/metals were higher in one specimen (serum or urine) but lower in the other (Selenium was lower in serum but higher in urine in the indium-exposed workers compared with the controls; likewise Thallium and Rubidium were higher in serum but lower in urine). Linear regression analyses, revealed significant correlations between serum and urine for indium, aluminum, arsenic, barium, cadmium, cesium, cobalt, selenium, silver, and zinc (P < 0.05). These data suggest that occupational exposure to indium and its compounds may disturb the homeostasis of trace elements in systemic circulation, indium concentrations in serum or urine appear reflective of workers’ exposure to ambient indium and their years of working, respectively. The serum/urine levels of essential metals are modified by exposure to indium in occupationally exposed workers. Further studies including larger sample size and more kinds of biological sample are needed to validate our findings.

Effects of occupational exposure to aluminium on some oxidative stress and DNA damage parameters

2017 ◽  
Vol 37 (9) ◽  
pp. 901-908 ◽  
Author(s):  
AM Samir ◽  
LA Rashed
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Occupational Exposure ◽  
Tail Length ◽  
Significant Negative Correlation ◽  
Exposed Workers ◽  
Occupationally Exposed ◽  
Aluminium Level ◽  
Total Antioxidant ◽  
Serum Aluminium

Aim: The aim of this work was to investigate the relationships between aluminium levels, oxidative status and DNA damage in workers occupationally exposed to aluminium. Subjects and methods: This study was conducted in a secondary aluminium smelter. It included 96 male workers occupationally exposed to aluminium fume and dust compared to 96 male nonexposed individuals. Full history and clinical examination were done for all participants. Laboratory investigations in the form of serum aluminium, total antioxidant capacity (TAC), urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) and comet assay test were performed. Results: Serum aluminium level ranged from 4 to 30 µg/L of median: 10 µg/L; urinary 8-OHdG ranged from 2.7 to 17.2 ng/mg creatinine of median: 7.6 ng/mg creatinine; comet tail length (CTL) ranged from 19.7 to 50.5 µm of median: 45 µm, were statistically significantly increased in the exposed group compared to nonexposed group. In exposed workers, a statistically significant positive correlations were found between serum aluminium level and urinary 8-OHdG ( r = 0.75, p < 0.001); aluminium level and CTL ( r = 0.71, p < 0.001); and urinary 8-OHdG and CTL ( r = 0.71, p < 0.001). There was a statistically significant negative correlation between serum aluminium and TAC ( r = −0.76, p < 0.001). Conclusion: Occupational exposure to aluminium in secondary aluminium smelters was related to the induction of oxidative stress and DNA damage. This may promote the development of adverse health hazards in the exposed workers

Influence of zinc levels on the toxic manifestations of lead exposure among the occupationally exposed workers

2019 ◽  
Vol 26 (32) ◽  
pp. 33541-33554 ◽  
Author(s):  
Ab Latif Wani ◽  
Mohd Owais Ansari ◽  
Md. Fahim Ahmad ◽  
Nuzhat Parveen ◽  
Hifzur R. Siddique ◽  
...  
Keyword(s):  
Lead Exposure ◽  
Exposed Workers ◽  
Occupationally Exposed ◽  
Zinc Levels

scholarly journals Influence of occupational exposure to low-dose ionizing radiation on the plasma activity of superoxide dismutase and glutathione level

2008 ◽  
Vol 65 (8) ◽  
pp. 613-618 ◽  
Author(s):  
Branka Djurovic ◽  
Vesna Spasic-Jokic ◽  
Branislav Djurovic
Keyword(s):  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Occupational Exposure ◽  
Adaptive Response ◽  
Antioxidant Defense ◽  
Low Doses ◽  
Sod Activity ◽  
Blood Samples ◽  
Exposed Workers ◽  
Occupationally Exposed

Background/Aim. During exposure to low-level doses (LLD) of ionizing radiation (IR), the most of harmful effects are produced indirectly, through radiolysis of water and formation of reactive oxygen species (ROS). The antioxidant enzymes - superoxide dismutase (SOD): manganese SOD (MnSOD) and copper-zinc SOD (CuZnSOD), as well as glutathione (GSH), are the most important intracellular antioxidants in the metabolism of ROS. Overproduction of ROS challenges antioxidant enzymes. The aim of this study was to examine if previous exposure to low doses of IR induces adaptive response by means of stimulation of intracellular antioxidant defense system. Methods. We investigated a group of medical workers occupationally exposed to IR (n = 44), 29 male and 15 female. The controls (n = 33) consisted of medical workers not exposed to IR, 23 male and 10 female. The examinees from both groups worked in the same environment and matched in crucial characteristics. All measurements were performed by a calibrated thermoluminiscent dosimeter type CaF2:Mn. SOD activity and GSH content were measured spectrophotometrically in the plasma of both groups of medical workers. Half of each blood sample was irradiated by 2Gy of ? radiation, dose-rate 0.45 Gy/min, and the distance from the source of 74 cm. Results. The dosimetry results indicate that occupational doses were very low. Our results confirmed significantly higher SOD activity in the exposed vs. unexposed workers (p < 0.00006). SOD activity after irradiation of blood samples failed to show a significant difference between the exposed workers and the controls (p = 0.905), even the difference in each group before and after the irradiation was significant. In blood samples of the exposed workers expression of enzymes after the irradiation, was not as high as in the controls, or even in the case of the exposed in nuclear medicine personnel, SOD activity was decreased. There were no significant differences in the content of GSH between the groups. Conclusion. Our results pointed out that occupational exposure to low doses of IR compromised mitochondrial function. During occupational exposure, the activity of antioxidant enzymes was increased as a protection against the increased production of ROS. After high-dose irradiation dysfunction of mitochondrial system was noticed, suggesting the break-down of antioxidant defense and failure of an adaptive response. Therefore, the "chronic oxidative stress" might reduce antioxidant defense in the case of accidental exposure to high doses of IR. It could indirectly increase the incidence of some other "free radicals' diseases" in occupationally exposed personnel. .

scholarly journals O1D.4 Occupational exposure to formaldehyde in france in 2015

2019 ◽  
Vol 76 (Suppl 1) ◽  
pp. A10.1-A10
Author(s):  
Laurène Delabre ◽  
Loïc Garras ◽  
Marie Houot ◽  
Corinne Pilorget
Keyword(s):  
Occupational Exposure ◽  
Large Range ◽  
International Agency ◽  
Exposure Rate ◽  
Construction Work ◽  
Working Population ◽  
Job Exposure Matrix ◽  
Personal Services ◽  
Exposed Workers ◽  
Occupationally Exposed

ContextFormaldehyde has been used in a large range of activities for decades. It was classified as human carcinogenic in 2004 by the International Agency for Research on Cancer and in France, formaldehyde has been regulated as a carcinogen since 2007.The aim of this work is to describe the occupational exposure to formaldehyde in France in 2015 and to identify the most exposed activities.MethodA formaldehyde job-exposure matrix, developed under the MATGÉNÉ programme, provides an exhaustive and retrospective exposure assessment for all jobs in France. These data were linked with the 2015 French census, annually elaborated from 2013 to 2017, to estimate the occupational exposure prevalence by gender, occupation, industries and worker status.ResultsIn 2015, 90 000 workers were occupationally exposed to formaldehyde (3.5‰ of the French population at work), 60 600 (4.6‰) among men and 29 400 (2.4‰) among women.The industries with the highest prevalence exposure rate were for men veterinary area (8.8%), wood industries (7.7%) and agriculture (4.8%); for women, veterinary area (7.3%), fishing and aquaculture (5.3%) and agriculture (5.1%).The exposed workers are retrieved in agriculture (26%), healthcare sectors (13,5%) and specialized construction work (12%) for employees and agriculture (69.6%), specialized construction work (13.5%) and other personal services (8.1%) for people with worker status different (mostly self-employed).ConclusionThese results, the first describing the occupational exposure to formaldehyde in France, according to gender for the entire working population, show the importance of regulation in the variation of occupational exposure prevalence rates. This information will help in the surveillance of this occupational risk and to prioritize prevention actions.

Evaluation of the status and the relationship between essential and toxic elements in the hair of occupationally exposed workers

2018 ◽  
Vol 190 (12) ◽  
Author(s):  
Mohamed Anouar Nouioui ◽  
Manel Araoud ◽  
Marie-Laure Milliand ◽  
Frédérique Bessueille-Barbier ◽  
Dorra Amira ◽  
...  
Keyword(s):  
Toxic Elements ◽  
Exposed Workers ◽  
The Status ◽  
Occupationally Exposed ◽  
Essential And Toxic Elements ◽  
The Relationship

scholarly journals n-Hexane metabolism in occupationally exposed workers.

1984 ◽  
Vol 41 (4) ◽  
pp. 533-538 ◽  
Author(s):  
A Mutti ◽  
M Falzoi ◽  
S Lucertini ◽  
G Arfini ◽  
M Zignani ◽  
...  
Keyword(s):  
Exposed Workers ◽  
Occupationally Exposed

scholarly journals Using tropicamide and phenylephrine without cyclopentolate for pupil dilation in cataract surgery reduces postoperative intraocular pressure rise

2020 ◽  
Vol 17 (3) ◽  
pp. 285-289
Author(s):  
Rachel Xuan ◽  
Keith Ong
Keyword(s):  
Intraocular Pressure ◽  
Retrospective Study ◽  
Cataract Surgery ◽  
Medical Records ◽  
Pressure Rise ◽  
Pupil Dilation ◽  
The Other ◽  
Sample Population ◽  
Iop Elevation ◽  
Larger Sample

The aim of this retrospective study was to evaluate whether intraocular (IOP) elevation post-cataract surgery can be reduced by using tropicamide and phenylephrine only, without cyclopentolate. Medical records across two surgical facilities were analyzed. One surgical facility (Cohort A) used a combination of tropicamide, cyclopentolate, and phenylephrine preoperatively, while the other (Cohort B) used tropicamide and phenylephrine only. Of patients in Cohort A, 63.6% (n = 7) had a higher IOP in the operated eye, while it was only 27.3% (n = 3) in Cohort B. Therefore, it is preferable to exclude the use of cyclopentolate in the preoperative dilation regimen of patients undergoing cataract surgery. However, a study with a larger sample population is required to further evaluate the significance of these results.

scholarly journals The Relationships between Cholesterol and Suicide: An Update

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Domenico De Berardis ◽  
Stefano Marini ◽  
Monica Piersanti ◽  
Marilde Cavuto ◽  
Giampaolo Perna ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Membrane ◽  
The Other ◽  
Core Component ◽  
Cell Membrane Stability ◽  
Cholesterol Levels ◽  
The Central Nervous System ◽  
Larger Sample

Cholesterol is a core component of the central nervous system, essential for the cell membrane stability and the correct functioning of neurotransmission. It has been observed that cholesterol may be somewhat associated with suicidal behaviours. Therefore, the aim of this paper was to elucidate current facts and views about the role of cholesterol levels in mood disorders. The majority of the studies reviewed in the present paper suggest an interesting relationship between cholesterol (especially lower levels) and suicidality. On the other hand, particularly during the last years, relationships between serum cholesterol and suicidality were doubted on the basis of some recent studies that have not found any correlation. However, the debate on relationships between cholesterol and suicide is open and longitudinal studies on a larger sample of patients are needed to further clarify this important issue.

Anesthetic gases and occupationally exposed workers

2014 ◽  
Vol 37 (1) ◽  
pp. 267-274 ◽  
Author(s):  
Teodorico Casale ◽  
Tiziana Caciari ◽  
Maria Valeria Rosati ◽  
Pier Agostino Gioffrè ◽  
Maria Pia Schifano ◽  
...  
Keyword(s):  
Exposed Workers ◽  
Occupationally Exposed ◽  
Anesthetic Gases
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