scholarly journals Prevalence of pectus excavatum in an adult population-based cohort estimated from radiographic indices of chest wall shape

PLoS ONE ◽  
2020 ◽  
Vol 15 (5) ◽  
pp. e0232575
Author(s):  
Mikaela Biavati ◽  
Julia Kozlitina ◽  
Adam C. Alder ◽  
Robert Foglia ◽  
Roderick W. McColl ◽  
...  
Keyword(s):  
Chest Wall ◽  
Pectus Excavatum ◽  
Adult Population ◽  
Population Based

scholarly journals Systemic Antibiotics and Obesity: Analyses from a Population-Based Cohort

2021 ◽  
Vol 10 (12) ◽  
pp. 2601
Author(s):  
So Young Park ◽  
Morena Ustulin ◽  
SangHyun Park ◽  
Kyung-Do Han ◽  
Joo Young Kim ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Adult Population ◽  
Antibiotic Use ◽  
Population Based ◽  
Obesity Risk ◽  
Gram Negative ◽  
Korean Adult ◽  
Korean National Health Insurance ◽  
Gram Negative Organisms ◽  
Systemic Antibiotics

Background: In this study, we analyzed the association between antibiotic use and obesity and metabolic syndrome (MS) in a Korean adult population. Methods: Subjects using the Korean National Health Insurance Service sample cohort were retrospectively analyzed in 2015. The differences in obesity and metabolic syndrome (MS) status were compared and analyzed according to duration of systemic antibiotic treatment in the previous 10 years (non-users, 1st, 2nd, and 3rd tertile). Results: Subjects who used systemic antibiotics for longer periods were older, satisfied more criteria for MS, and had more comorbidities than non-users (non-users vs. 3rd tertile, p < 0.0001 for all). After adjusting for confounding factors, the risk of obesity was higher in subjects who used systemic antibiotics for longer periods than in non-users (non-users vs. 3rd tertile, OR (odds ratio) (95% CI (confidence interval)); 1.20 (1.12–1.38)). The criteria for MS were more satisfied in the 3rd tertile than in non-users. A higher obesity risk was also found in subjects treated with antibiotics targeting Gram-negative organisms than in those targeting Gram-positive organisms. Conclusion: The risk of obesity was higher in subjects who took systemic antibiotics more frequently. The risk was more prominent when they took antibiotics targeting Gram-negative bacteria.

scholarly journals Long-term mortality due to infection associated with elevated liver enzymes: a population-based cohort study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tak Kyu Oh ◽  
Eun Sun Jang ◽  
In-Ae Song
Keyword(s):  
Cohort Study ◽  
Liver Enzymes ◽  
Adult Population ◽  
Population Based ◽  
Study Data ◽  
Point Increase ◽  
Elevated Liver Enzymes ◽  
Glutamyl Transpeptidase ◽  
Long Term Mortality

AbstractWe aimed to investigate whether elevated liver enzymes in the adult population were associated with mortality due to infection. As a population-based cohort study, data from the National Health Insurance Service Health Screening Cohort were used. Adult individuals (aged ≥ 40 years) who underwent standardized medical examination between 2002 and 2003 were included, and infectious mortality was defined as mortality due to infection between 2004 and 2015. Aspartate transaminase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (γ-GTP), AST/ALT ratio, and dynamic AST/ALT ratio (dAAR) were included in multivariable Cox modeling. A total of 512,746 individuals were included in this study. Infectious mortality occurred in 2444 individuals (0.5%). In the multivariable model, moderate and severe elevation in AST was associated with 1.94-fold [hazard ratio (HR):1.94, 95% confidence interval (CI) 1.71–2.19; P < 0.001] and 3.93-fold (HR: 3.93, 95% CI 3.05–5.07; P < 0.001) higher infectious mortality respectively, compared with the normal AST group. Similar results were observed for moderate and severe elevation in ALT and mild, moderate, and severe elevation in γ-GTP. Additionally, a 1-point increase in the AST/ALT ratio and dAAR was associated with higher infection mortality. Elevated liver enzymes (AST, ALT, AST/ALT ratio, γ-GTP, and dAAR) were associated with increased infectious mortality.

scholarly journals Factors Influencing SARS-CoV-2 Vaccine Acceptance and Hesitancy in a Population-Based Sample in Italy

Vaccines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 633
Author(s):  
Marco Del Riccio ◽  
Sara Boccalini ◽  
Lisa Rigon ◽  
Massimiliano Alberto Biamonte ◽  
Giuseppe Albora ◽  
...  
Keyword(s):  
Online Survey ◽  
Adult Population ◽  
Herd Immunity ◽  
Population Based ◽  
Vaccine Hesitancy ◽  
Convenience Sample ◽  
Major Barrier ◽  
Trust In Institutions ◽  
General Adult Population ◽  
High Level

Vaccination against SARS-CoV-2 represents an effective and safe tool to protect the population against the disease; however, COVID-19 vaccine hesitancy could be a major barrier to achieving herd immunity. Despite the severity of the current pandemic, the population’s intention to get vaccinated against COVID-19 is still not clear. The aim of this study was to evaluate the intention to get vaccinated against COVID-19 among a convenience sample of the general population resident in Italy and the factors associated with hesitancy and acceptance of the vaccine in the context of the current pandemic before the rolling out of COVID-19 vaccines. An anonymous online survey was diffused among a general adult population living in Italy. Participants aged 18 or older and living in Italy were considered eligible. Incomplete questionnaires were excluded. Overall, 7605 valid questionnaires were collected. Most of the participants (81.9%) were inclined to get vaccinated; male sex (OR 1.38, 95% CI 1.12–1.71), a high level of trust in institutions (OR 3.93, 95% CI 2.04–7.83), and personal beliefs about high safety of COVID-19 vaccines (OR 56.33, 95% CI 31.57–105.87) were found to be among the significant predictors of COVID-19 acceptance. These data could help design larger studies to address the problem of COVID-19 vaccine hesitancy in the current pandemic.

scholarly journals Neighbourhood characteristics as a predictor of adherence to dietary recommendations: A population-based cohort study of Finnish adults

2020 ◽  
pp. 140349482097149
Author(s):  
Hanna Lagström ◽  
Jaana I. Halonen ◽  
Sakari Suominen ◽  
Jaana Pentti ◽  
Sari Stenholm ◽  
...  
Keyword(s):  
Population Density ◽  
Dietary Habits ◽  
Metabolic Diseases ◽  
Adult Population ◽  
Age Groups ◽  
Population Based ◽  
Dietary Recommendations ◽  
Neighbourhood Characteristics ◽  
Severe Life Events ◽  
Dietary Score

Aims: To investigate the association of six-year cumulative level of socioeconomic neighbourhood disadvantage and population density with subsequent adherence to dietary recommendations, controlling for preceding dietary adherence, in adults in Finland. Methods: Population-based Health and Social Support (HeSSup) study participants from four age groups (20–24, 30–34, 40–44 and 50–54 years at baseline in 1998). Data on diet and alcohol consumption were obtained from the 2003 and 2012 surveys and information on neighbourhoods from Statistics Finland Grid database ( n = 10,414 men and women). Participants diet was measured as adherence to Nordic Nutrition recommendation (score range 0–100). Neighbourhood disadvantage was measured by median household income, proportion of those with primary education only and unemployment rate, and population density by the number of adult population between years 2007 and 2012. Linear models were used to assess the associations of neighbourhood characteristics with the score for adherence to dietary recommendations in 2012. Results: Cumulative neighbourhood socioeconomic disadvantage was associated with slightly weaker (1.49 (95% confidence interval (CI) −1.89 to −1.09) point decrease in dietary score) adherence while higher population density was associated with better (0.70 (95% CI 0.38−1.01) point increase in dietary score) adherence to dietary recommendations. These associations remained after controlling for prior dietary habits, sociodemographic, chronic cardio-metabolic diseases, and severe life events. Conclusions: These longitudinal findings support the hypothesis that neighbourhood characteristics affect dietary habits.

scholarly journals Prevalence of systemic lupus erythematosus in Spain: higher than previously reported in other countries?

Rheumatology ◽  
2020 ◽  
Vol 59 (9) ◽  
pp. 2556-2562 ◽  
Author(s):  
Raúl Cortés Verdú ◽  
José M Pego-Reigosa ◽  
Daniel Seoane-Mato ◽  
Mercedes Morcillo Valle ◽  
Deseada Palma Sánchez ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Adult Population ◽  
Geographical Area ◽  
Geographic Origin ◽  
The United States ◽  
Epidemiological Studies ◽  
Population Based ◽  
Cross Sectional Study ◽  
Medical Visit ◽  
Cross Sectional

Abstract Objectives Prevalence of SLE varies among studies, being influenced by study design, geographical area and ethnicity. Data about the prevalence of SLE in Spain are scarce. In the EPISER2016 study, promoted by the Spanish Society of Rheumatology, the prevalence estimate of SLE in the general adult population in Spain has been updated and its association with sociodemographic, anthropometric and lifestyle variables has been explored. Methods Population-based multicentre cross-sectional study, with multistage stratified and cluster random sampling. Participants were contacted by telephone to carry out a questionnaire for the screening of SLE. Investigating rheumatologists evaluated positive results (review of medical records and/or telephone interview, with medical visit if needed) to confirm the diagnosis. To calculate the prevalence and its 95% CI, the sample design was taken into account and weighing was calculated considering age, sex and geographic origin. Multivariate logistic regression models were defined to analyse which sociodemographic, anthropometric and lifestyle variables included in the telephone questionnaire were associated with the presence of SLE. Results 4916 subjects aged 20 years or over were included. 16.52% (812/4916) had a positive screening result for SLE. 12 cases of SLE were detected. The estimated prevalence was 0.21% (95% CI: 0.11, 0.40). SLE was more prevalent in the rural municipalities, with an odds ratio (OR) = 4.041 (95% CI: 1.216, 13.424). Conclusion The estimated prevalence of SLE in Spain is higher than that described in most international epidemiological studies, but lower than that observed in ethnic minorities in the United States or the United Kingdom.

The Prevalence of Sexual Abuse in Institutions: Results From a Representative Population-Based Sample in Germany

Sexual Abuse ◽  
2018 ◽  
Vol 31 (6) ◽  
pp. 643-661 ◽  
Author(s):  
Andreas Witt ◽  
Miriam Rassenhofer ◽  
Marc Allroggen ◽  
Elmar Brähler ◽  
Paul L. Plener ◽  
...  
Keyword(s):  
Sexual Abuse ◽  
Sexual Intercourse ◽  
Adult Population ◽  
Population Based ◽  
Adult Women ◽  
Institutional Settings ◽  
General Adult Population ◽  
Nature Contact ◽  
Protective Strategies ◽  
Type Of Institution

The lifetime prevalence of sexual abuse in institutional settings in Germany was examined in a sample representative of the general adult population ( N = 2,437). Participants completed a survey on whether they had ever experienced such abuse, its nature (contact, noncontact, forced sexual, intercourse), the type of institution (e.g. school, club), and the relationship of perpetrator to victim (peer, caregiver, staff member). Overall, 3.1% of adult respondents (women: 4.8%, men: 0.8%) reported having experienced some type of sexual abuse in institutions. Adult women reported higher rates of all types than did men, with rates of 3.9% versus 0.8% for contact sexual abuse, 1.2% versus 0.3% for noncontact sexual abuse, and 1.7% versus 0.2% for forced sexual intercourse. We conclude that a remarkable proportion of the general population experiences sexual abuse in institutions, underscoring the need for development of protective strategies. Especially, schools seem to represent good starting points for primary prevention strategies.

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