scholarly journals Low Dose Prenatal Alcohol Exposure Does Not Impair Spatial Learning and Memory in Two Tests in Adult and Aged Rats

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e101482 ◽  
Author(s):  
Carlie L. Cullen ◽  
Thomas H. J. Burne ◽  
Nickolas A. Lavidis ◽  
Karen M. Moritz
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Low Dose ◽  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
Spatial Learning And Memory ◽  
Aged Rats ◽  
Prenatal Alcohol

Tocotrienol Rich Fraction Reverses Age-Related Deficits in Spatial Learning and Memory in Aged Rats

Lipids ◽  
2014 ◽  
Vol 49 (9) ◽  
pp. 855-869 ◽  
Author(s):  
Nursiati Mohamad Taridi ◽  
Nazirah Abd Rani ◽  
Azian Abd Latiff ◽  
Wan Zurinah Wan Ngah ◽  
Musalmah Mazlan
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Spatial Learning And Memory ◽  
Aged Rats ◽  
Age Related ◽  
Tocotrienol Rich Fraction

Implicit and explicit memory functioning in children with heavy prenatal alcohol exposure

1999 ◽  
Vol 5 (5) ◽  
pp. 462-471 ◽  
Author(s):  
SARAH N. MATTSON ◽  
EDWARD P. RILEY
Keyword(s):  
Down Syndrome ◽  
Free Recall ◽  
Recognition Memory ◽  
Learning And Memory ◽  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
Memory Deficits ◽  
Children With Down Syndrome ◽  
Memory Functioning ◽  
Prenatal Alcohol

Prenatal alcohol exposure is associated with widespread and devastating neurodevelopmental deficits. Numerous reports have suggested memory deficits in both humans and animals exposed prenatally to alcohol. However, the nature of these memory deficits remains to be characterized. Recently children with fetal alcohol syndrome were shown to have learning and memory deficits on a verbal learning and memory measure that involved free recall and recognition memory. The current study seeks to further characterize memory functioning in children with heavy prenatal alcohol exposure by evaluating priming performance. The choice of task is also relevant given previous studies of memory performance in patient groups with and without involvement of the basal ganglia, a group of structures known to be affected in fetal alcohol syndrome. Three groups were evaluated for lexical priming, free recall, recognition memory, and verbal fluency: (1) children with heavy prenatal alcohol exposure; (2) children with Down syndrome; and (3) nonexposed controls. The children with Down syndrome showed significantly less priming than alcohol-exposed children, who did not differ from controls. In addition, the alcohol-exposed children were impaired on the free recall task but not on the recognition memory task, whereas the children with Down syndrome performed significantly worse than the alcohol-exposed group on both tasks. Finally, on the verbal fluency task, children with heavy prenatal alcohol exposure were impaired on both category and letter fluency, but the degree of impairment was greater for letter fluency. These results further characterize the memory deficits in children with heavy prenatal alcohol exposure suggesting that in spite of learning and memory deficits, they are able to benefit from priming of verbal information. (JINS, 1999, 5, 462–471.)

Blockade of hippocampal bradykinin B1 receptors improves spatial learning and memory deficits in middle-aged rats

2017 ◽  
Vol 316 ◽  
pp. 74-81 ◽  
Author(s):  
Rafael M. Bitencourt ◽  
Ana C. Guerra de Souza ◽  
Maíra A. Bicca ◽  
Fabrício A. Pamplona ◽  
Nelson de Mello ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Memory Deficits ◽  
Spatial Learning And Memory ◽  
Aged Rats ◽  
Middle Aged ◽  
B1 Receptors ◽  
Learning And Memory Deficits

Effect of chronic exposure of Losartan in mouse prenatal alcohol exposure (PAE) model

2017 ◽  
Vol 41 (S1) ◽  
pp. S600-S600
Author(s):  
A. Takyi
Keyword(s):  
Object Recognition ◽  
Learning And Memory ◽  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
Novel Object Recognition ◽  
The Novel ◽  
Novel Object ◽  
Beneficial Effects ◽  
Prenatal Alcohol ◽  
Competing Interest

Background and aimsFoetal alcohol syndrome (FAS) is a condition that currently affects 1% of babies born in Europe and North America. It is characterised by memory impairment, developmental delay and distinctive facial features. This research uses a mouse prenatal alcohol exposure (PAE) model to explore the effects of PAE on learning, memory and to explore the potentially beneficial effects of common drugs previously shown to have cognitive enhancing effects in both humans and animals.MethodsSixty mice (M = 30 F = 30) C57 mice were exposed to 5% ethanol throughout pregnancy. After weaning the offspring received Losartan (10 mg/kg) via their drinking water for 8 weeks. At 3 months, learning and memory was assessed using the novel object recognition paradigm.ResultsPAE caused a significant decrease in offspring body weight. Treatment with Losartan caused no growth impairment or renal damage. Novel object recognition indicated that PAE caused male offspring to spend significantly less time exploring the novel object than controls and that treatment with Losartan had the effect of improving awareness of the novel object both in the control and alcohol group and decreasing anxiety (P ≤ 0.05). A significant opposite effect was noticed in the female alcohol progeny when compared to the male alcohol progeny (P ≤ 0.05). Losartan in female alcohol progeny had no effect on anxiety. Male control Losartan spent more time exploring the novel object than male alcohol Losartan (P ≤ 0.05).ConclusionsLosartan had no deleterious effects on the development of the animals, and was able to improve learning and memory in control animals without effect in PAE mice.Disclosure of interestThe author has not supplied his declaration of competing interest.

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