scholarly journals Neutrophil Extracellular Traps and Bacterial Biofilms in Middle Ear Effusion of Children with Recurrent Acute Otitis Media – A Potential Treatment Target

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e53837 ◽  
Author(s):  
Ruth B. Thornton ◽  
Selma P. Wiertsema ◽  
Lea-Ann S. Kirkham ◽  
Paul J. Rigby ◽  
Shyan Vijayasekaran ◽  
...  
Keyword(s):  
Middle Ear ◽  
Acute Otitis Media ◽  
Neutrophil Extracellular Traps ◽  
Bacterial Biofilms ◽  
Potential Treatment ◽  
Middle Ear Effusion ◽  
Treatment Target ◽  
Extracellular Traps ◽  
Recurrent Acute Otitis Media ◽  
Ear Effusion

Comparative Treatment Trial of Augmentin Versus Cefaclor for Acute Otitis Media with Effusion

PEDIATRICS ◽  
1985 ◽  
Vol 75 (5) ◽  
pp. 819-826
Author(s):  
Carla M. Odio ◽  
Helen Kusmiesz ◽  
Sharon Shelton ◽  
John D. Nelson
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Otitis Media With Effusion ◽  
Acute Otitis Media ◽  
Middle Ear Effusion ◽  
Recurrent Acute Otitis Media ◽  
Potassium Clavulanate ◽  
Branhamella Catarrhalis ◽  
Viridans Group Streptococci ◽  
Ear Effusion

A total of 150 children with acute otitis media were randomly allocated to treatment with amoxicillin-potassium clavulanate (Augmentin) or with cefaclor. Each drug was given in a daily dosage of approximately 40 mg/kg in three divided doses for ten days. Tympanocentesis done before treatment yielded specimens that contained pneumococcus or Haemophilus sp or both in 67% of specimens. Viridans group streptococci were isolated from 10% of specimens and Branhamella catarrhalis from 6%. Patients were scheduled for followup examinations at midtreatment, end of therapy, and at 30, 60, and 90 days. Of the 150 children, 130 were evaluable. Five of 60 patients (8%) treated with cefaclor were considered therapeutic failures because of persistent purulent drainage and isolation of the original pathogen or suprainfection. There were no failures among patients treated with Augmentin (P = .019). Rates of relapse, recurrent acute otitis media with effusion, and persistent middle ear effusion were comparable in the two groups of patients. Diaper rash, or loose stools, or both were significantly more common in children treated with Augmentin (34%) than in those taking cefaclor (12%), but in no case was it necessary to discontinue medication because of these mild side effects (P = .002). Cefaclor therapy was discontinued in one patient because of severe abdominal pain and vomiting. In this study, treatment with Augmentin was superior to treatment with cefaclor in the acute phase of acute otitis media with effusion, but Augmentin produced more adverse effects. The rates of persistent middle ear effusion and recurrent acute otitis media with effusion were comparable with the two regimens.

Tympanometric Pattern Classification in Relation to Middle Ear Effusions

1975 ◽  
Vol 84 (1) ◽  
pp. 56-64 ◽  
Author(s):  
Quinter C. Beery ◽  
Charles D. Bluestone ◽  
W. Scott Andrus ◽  
Erdem I. Cantekin
Keyword(s):  
Otitis Media ◽  
Pattern Classification ◽  
Middle Ear ◽  
Acute Otitis Media ◽  
Correct Prediction ◽  
Middle Ear Effusion ◽  
Middle Ear Pressure ◽  
Recurrent Acute Otitis Media ◽  
History Of ◽  
Ear Effusion

Tympanometric evaluation using an otoadmittance meter and X-Y plotter was performed on 129 ears of 70 children with history of recurrent acute otitis media, or evidence otoscopically of persistent middle ear effusion, or both. Myringotomy, performed immediately following the tympanometric procedure, confirmed the presence or absence of effusion. Following myringotomy, tympanometric patterns, as shown by susceptance and conductance tracings at 220 and 660 Hz, were identified and middle ear pressures and otoadmittance peak values were determined. These findings were compared and criteria were developed which best determined the presence or absence of effusion. The results revealed the following: 1) High negative middle ear pressure is not necessarily a reliable indicator of middle ear effusion. 2) Tympanometry can be used reliably as an indicator of effusion. A combination of pattern classification and susceptance criteria enabled correct prediction of effusion in 93% of these children. One pattern at B660 was found to be pathognomonic of effusion. 3) In general, otoadmittance at 660 Hz appears to be a better indicator of effusion than 220 Hz.

Tympanometric Patterns Found in Middle Ear Effusions

1977 ◽  
Vol 86 (4_suppl2) ◽  
pp. 16-20 ◽  
Author(s):  
Erdem I. Cantekin ◽  
Quinter C. Beery ◽  
Charles D. Bluestone
Keyword(s):  
Pattern Classification ◽  
Middle Ear ◽  
Acoustic Impedance ◽  
Acute Otitis Media ◽  
Middle Ear Effusion ◽  
Recurrent Acute Otitis Media ◽  
History Of ◽  
Correct Association ◽  
Ear Effusion

In 120 ears of 67 children with a history of recurrent acute otitis media or otoscopic evidence of persistent middle ear effusion, or both, tympanograms were obtained using an otoadmittance meter and an electro-acoustic impedance bridge. Myringotomy was performed immediately following the tympanometric evaluation confirming the presence or absence of middle ear effusion. The comparison of myringotomy findings with a tympanometric pattern classification revealed 85.8% overall correct association with the presence or absence of a middle ear effusion for both instruments. In 83.3% of the cases, there was agreement in the classification of the tympanogram between the otoadmittance meter and the electro-acoustic bridge.

scholarly journals Long-term prognosis of acute otitis media in infancy: determinants of recurrent acute otitis media and persistent middle ear effusion

2005 ◽  
Vol 23 (1) ◽  
pp. 40-45 ◽  
Author(s):  
Roger AMJ Damoiseaux ◽  
Maroeska M Rovers ◽  
Frank AM Van Balen ◽  
Arno W Hoes ◽  
Ruut A de Melker
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Acute Otitis Media ◽  
Middle Ear Effusion ◽  
Recurrent Acute Otitis Media ◽  
Long Term Prognosis ◽  
Ear Effusion

scholarly journals The management of acute otitis media

1984 ◽  
Vol 22 (14) ◽  
pp. 53-54
Keyword(s):  
Hearing Loss ◽  
Otitis Media ◽  
Clinical Examination ◽  
Middle Ear ◽  
Acute Otitis Media ◽  
Infectious Complications ◽  
Middle Ear Effusion ◽  
Suppurative Otitis Media ◽  
Painful Condition ◽  
Ear Effusion

Acute suppurative otitis media (AOM) is a common, painful condition affecting 20% of children under 4 years at least once a year,1 and perhaps more in infancy when clinical examination is most difficult. Infectious complications such as mastoiditis, meningitis and cerebral abscess are now rare, but chronic middle ear effusion and hearing loss remain common. Hearing loss may persist long after the infective episode,2 and may impair learning.

scholarly journals Characterization of bacteria causing acute otitis media using Raman microspectroscopy

2017 ◽  
Vol 9 (12) ◽  
pp. 1864-1871 ◽  
Author(s):  
O. D. Ayala ◽  
C. A. Wakeman ◽  
I. J. Pence ◽  
C. M. O'Brien ◽  
J. A. Werkhaven ◽  
...  
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Acute Otitis Media ◽  
Raman Microspectroscopy ◽  
Bacterial Identification ◽  
Middle Ear Effusion ◽  
Ear Effusion

Raman microspectroscopy was used to characterize and identify the three main pathogens that cause acute otitis media (AOM)in vitro. Cultured middle ear effusion from patients was studied and results suggest the potential of using this technique to aid in accurately diagnosing AOM and providing physicians with bacterial identification to guide treatment.

Disappearance of middle ear effusion in acute otitis media monitored daily with tympanometry

2006 ◽  
Vol 95 (3) ◽  
pp. 359-363 ◽  
Author(s):  
Marjo Renko ◽  
Tero Kontiokari ◽  
Katariina Jounio-Ervasti ◽  
Heikki Rantala ◽  
Matti Uhari
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Acute Otitis Media ◽  
Middle Ear Effusion ◽  
Ear Effusion
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