scholarly journals Notch-Mediated Suppression of TSC2 Expression Regulates Cell Differentiation in the Drosophila Intestinal Stem Cell Lineage

PLoS Genetics ◽  
2012 ◽  
Vol 8 (11) ◽  
pp. e1003045 ◽  
Author(s):  
Subir Kapuria ◽  
Jason Karpac ◽  
Benoit Biteau ◽  
DaeSung Hwangbo ◽  
Heinrich Jasper
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Cell Lineage ◽  
Intestinal Stem Cell ◽  
Stem Cell Lineage

scholarly journals Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates

2021 ◽  
Vol 23 (1) ◽  
pp. 23-31
Author(s):  
Anika Böttcher ◽  
Maren Büttner ◽  
Sophie Tritschler ◽  
Michael Sterr ◽  
Alexandra Aliluev ◽  
...  
Keyword(s):  
Stem Cell ◽  
Paneth Cell ◽  
Cell Lineage ◽  
Intestinal Stem Cell ◽  
Cell Fates ◽  
Stem Cell Lineage ◽  
Lineage Priming ◽  
Canonical Wnt

scholarly journals Generation and Staining of Intestinal Stem Cell Lineage in Adult Midgut

2012 ◽  
pp. 47-69 ◽  
Author(s):  
Shree Ram Singh ◽  
Manoj K. Mishra ◽  
Madhuri Kango-Singh ◽  
Steven X. Hou
Keyword(s):  
Stem Cell ◽  
Cell Lineage ◽  
Intestinal Stem Cell ◽  
Stem Cell Lineage

scholarly journals Intracellular pH dynamics regulates intestinal stem cell fate

2021 ◽  
Author(s):  
Diane L. Barber ◽  
Yi Liu ◽  
Efren Reyes ◽  
David Castillo-Azofeifa ◽  
Ophir D Klein ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Intracellular Ph ◽  
Paneth Cell ◽  
Cell Lineage ◽  
Adult Stem Cell ◽  
Intestinal Stem Cell ◽  
Cell Fate Specification ◽  
Stem Cell Fate ◽  
Stem Cell Lineage

Emerging evidence is revealing critical roles of intracellular pH (pHi) in development, but it remains unclear whether pHi regulates stem cell fate specification. We find that pHi dynamics is a key regulator of cell fate in the mouse intestinal stem cell lineage. We identify a pHi gradient along the intestinal crypt axis and find that dissipating this gradient inhibits crypt budding due to loss Paneth cell differentiation. Mechanistically, decreasing pHi biases intestinal stem cell fate toward the absorptive and away from the secretory lineage, by regulating the activity of the lineage transcription factor Atoh1. Our findings reveal a previously unrecognized role for pHi dynamics in the specification of cell fate within an adult stem cell lineage.

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