scholarly journals A Mechanical Design Principle for Tissue Structure and Function in the Airway Tree

2013 ◽  
Vol 9 (5) ◽  
pp. e1003083 ◽  
Author(s):  
Adam S. LaPrad ◽  
Kenneth R. Lutchen ◽  
Béla Suki
Keyword(s):  
Design Principle ◽  
Mechanical Design ◽  
Structure And Function ◽  
Tissue Structure ◽  
Airway Tree ◽  
And Function

scholarly journals Flavonoids in Skin Senescence Prevention and Treatment

2021 ◽  
Vol 22 (13) ◽  
pp. 6814
Author(s):  
Anna Domaszewska-Szostek ◽  
Monika Puzianowska-Kuźnicka ◽  
Alina Kuryłowicz
Keyword(s):  
Therapeutic Strategy ◽  
Cancer Susceptibility ◽  
Skin Aging ◽  
Structure And Function ◽  
Tissue Structure ◽  
Delayed Wound Healing ◽  
Secretory Phenotype ◽  
Cellular Pathways ◽  
And Function ◽  
Increased Susceptibility

Skin aging is associated with the accumulation of senescent cells and is related to many pathological changes, including decreased protection against pathogens, increased susceptibility to irritation, delayed wound healing, and increased cancer susceptibility. Senescent cells secrete a specific set of pro-inflammatory mediators, referred to as a senescence-associated secretory phenotype (SASP), which can cause profound changes in tissue structure and function. Thus, drugs that selectively eliminate senescent cells (senolytics) or neutralize SASP (senostatics) represent an attractive therapeutic strategy for age-associated skin deterioration. There is growing evidence that plant-derived compounds (flavonoids) can slow down or even prevent aging-associated deterioration of skin appearance and function by targeting cellular pathways crucial for regulating cellular senescence and SASP. This review summarizes the senostatic and senolytic potential of flavonoids in the context of preventing skin aging.

Reverse Engineering the Structure and Function of the Allegheny Mound Ant Neck (Insecta, Hymenoptera, Formica, Exsectoides)

2012 ◽  
Author(s):  
Vienny N. Nguyen ◽  
Blaine W. Lilly ◽  
Carlos E. Castro
Keyword(s):  
Mechanical Design ◽  
Structure And Function ◽  
Load Path ◽  
Supporting Surface ◽  
Form And Function ◽  
Formica Exsectoides ◽  
Sem Imaging ◽  
Heavy Loads ◽  
And Function ◽  
Mass Loads

Insects as mechanical systems have been optimized for form and function over millions of years. Ants, in particular, can lift and carry extremely heavy loads relative to their body mass. Loads are lifted with the mouthparts, transferred through the neck joint to the thorax, and distributed over six legs and feet that anchor to the supporting surface. While previous research efforts have explored attachment mechanisms of the feet, little is known about the mechanical design of the neck — the single joint that connects the load path from the thorax to the head. This work combines mechanical testing, computed tomography (CT) and scanning electron microscope (SEM) imaging, and computational modeling to better understand the mechanical structure-function relation of the ant neck joint.

Repair and recovery mechanisms following critical illness

2016 ◽  
Author(s):  
Geoffrey Bellingan ◽  
Brijesh V. Patel
Keyword(s):  
Critical Illness ◽  
Inflammatory Response ◽  
Inflammatory Responses ◽  
Tissue Injury ◽  
Structure And Function ◽  
Tissue Structure ◽  
Inflammatory Activation ◽  
Recovery Mechanisms ◽  
And Function

Inflammation is the beneficial host response to foreign challenge or tissue injury that ultimately leads to the restoration of tissue structure and function. Critical illness is associated with an overwhelming and prolonged inflammatory activation. Resolution of the inflammatory response is an active process that requires removal of the inciting stimuli, cessation of the pro-inflammatory response, a timely coordinated removal of tissue leukocyte infiltration, a conversion from ‘toxic’ to reparative tissue environment, and restoration of normal tissue structure and function. Mortality may result from deficits in these resolution mechanisms. Improved delivery of critical care through prevention of harm and removal of stimuli has already delivered significant mortality benefits. Most critically-ill patients present with uncontrolled inflammation, hence anti-inflammatory strategies ameliorating this response are likely to be too late and thus futile. Rather, strategies augmenting endogenous pathways involved in the control and appropriate curtailment of such inflammatory responses may promote resolution, repair, and catabasis. Recent evidence showing that inflammation does not simply ‘fizzle out’, but its resolution involves an active and coordinated series of events. Dysfunction of these resolution checkpoints alters the normal inflammatory pathway, and is implicated in the induction and maintenance of states such as ARDS and sepsis. Improved understanding of resolution biology should provide translational pathways to not only improve survival, but also to prevent long-term morbidity resulting from tissue damage.

Biophysical Modulation of Cell and Tissue Structure and Function

1995 ◽  
Vol 5 (2) ◽  
pp. 177-191 ◽  
Author(s):  
Janet Rubin ◽  
Clinton T. Rubin ◽  
Kenneth J. McLeod
Keyword(s):  
Structure And Function ◽  
Tissue Structure ◽  
And Function
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