scholarly journals Correction: Single-cell in vivo imaging of cellular circadian oscillators in zebrafish

PLoS Biology ◽  
2021 ◽  
Vol 19 (8) ◽  
pp. e3001382
Author(s):  
Haifang Wang ◽  
Zeyong Yang ◽  
Xingxing Li ◽  
Dengfeng Huang ◽  
Shuguang Yu ◽  
...  
Keyword(s):  
Single Cell ◽  
In Vivo Imaging ◽  
Circadian Oscillators

scholarly journals Single-cell in vivo imaging of cellular circadian oscillators in zebrafish

PLoS Biology ◽  
2020 ◽  
Vol 18 (3) ◽  
pp. e3000435 ◽  
Author(s):  
Haifang Wang ◽  
Zeyong Yang ◽  
Xingxing Li ◽  
Dengfeng Huang ◽  
Shuguang Yu ◽  
...  
Keyword(s):  
Single Cell ◽  
In Vivo Imaging ◽  
Circadian Oscillators

From In Vitro to In Vivo: Imaging from the Single Cell to the Whole Organism

2008 ◽  
Vol 44 (1) ◽  
Author(s):  
Jung Julie Kang ◽  
Ildiko Toma ◽  
Arnold Sipos ◽  
Janos Peti‐Peterdi
Keyword(s):  
Single Cell ◽  
In Vivo Imaging

scholarly journals Myelin replacement triggered by single-cell demyelination in mouse cortex

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Nicolas Snaidero ◽  
Martina Schifferer ◽  
Aleksandra Mezydlo ◽  
Bernard Zalc ◽  
Martin Kerschensteiner ◽  
...  
Keyword(s):  
Laser Ablation ◽  
Single Cell ◽  
In Vivo Imaging ◽  
Active Participant ◽  
Cell Replacement ◽  
Myelin Sheaths ◽  
Unmyelinated Axons ◽  
Single Axon ◽  
Mouse Cortex

Abstract Myelin, rather than being a static insulator of axons, is emerging as an active participant in circuit plasticity. This requires precise regulation of oligodendrocyte numbers and myelination patterns. Here, by devising a laser ablation approach of single oligodendrocytes, followed by in vivo imaging and correlated ultrastructural reconstructions, we report that in mouse cortex demyelination as subtle as the loss of a single oligodendrocyte can trigger robust cell replacement and remyelination timed by myelin breakdown. This results in reliable reestablishment of the original myelin pattern along continuously myelinated axons, while in parallel, patchy isolated internodes emerge on previously unmyelinated axons. Therefore, in mammalian cortex, internodes along partially myelinated cortical axons are typically not reestablished, suggesting that the cues that guide patchy myelination are not preserved through cycles of de- and remyelination. In contrast, myelin sheaths forming continuous patterns show remarkable homeostatic resilience and remyelinate with single axon precision.

Abstract 4293: In vivo imaging and tracking of a PARP inhibitor at single-cell resolution

2012 ◽  
Author(s):  
Katherine Yang ◽  
Greg Thurber ◽  
Thomas Reiner ◽  
Rainer Kohler ◽  
Ralph Weissleder
Keyword(s):  
Single Cell ◽  
In Vivo Imaging ◽  
Parp Inhibitor

scholarly journals Convergent molecular, cellular, and cortical neuroimaging signatures of major depressive disorder

2020 ◽  
Vol 117 (40) ◽  
pp. 25138-25149
Author(s):  
Kevin M. Anderson ◽  
Meghan A. Collins ◽  
Ru Kong ◽  
Kacey Fang ◽  
Jingwei Li ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Negative Affect ◽  
Depressive Disorder ◽  
Single Cell ◽  
In Vivo Imaging ◽  
Ex Vivo ◽  
Integrated Analysis ◽  
Down Regulation ◽  
Major Depressive

Major depressive disorder emerges from the complex interactions of biological systems that span genes and molecules through cells, networks, and behavior. Establishing how neurobiological processes coalesce to contribute to depression requires a multiscale approach, encompassing measures of brain structure and function as well as genetic and cell-specific transcriptional data. Here, we examine anatomical (cortical thickness) and functional (functional variability, global brain connectivity) correlates of depression and negative affect across three population-imaging datasets: UK Biobank, Brain Genomics Superstruct Project, and Enhancing NeuroImaging through Meta Analysis (ENIGMA; combined n ≥ 23,723). Integrative analyses incorporate measures of cortical gene expression, postmortem patient transcriptional data, depression genome-wide association study (GWAS), and single-cell gene transcription. Neuroimaging correlates of depression and negative affect were consistent across three independent datasets. Linking ex vivo gene down-regulation with in vivo neuroimaging, we find that transcriptional correlates of depression imaging phenotypes track gene down-regulation in postmortem cortical samples of patients with depression. Integrated analysis of single-cell and Allen Human Brain Atlas expression data reveal somatostatin interneurons and astrocytes to be consistent cell associates of depression, through both in vivo imaging and ex vivo cortical gene dysregulation. Providing converging evidence for these observations, GWAS-derived polygenic risk for depression was enriched for genes expressed in interneurons, but not glia. Underscoring the translational potential of multiscale approaches, the transcriptional correlates of depression-linked brain function and structure were enriched for disorder-relevant molecular pathways. These findings bridge levels to connect specific genes, cell classes, and biological pathways to in vivo imaging correlates of depression.

scholarly journals Single cell resolution in vivo imaging of DNA damage following PARP inhibition

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Katherine S. Yang ◽  
Rainer H. Kohler ◽  
Matthieu Landon ◽  
Randy Giedt ◽  
Ralph Weissleder
Keyword(s):  
Dna Damage ◽  
Single Cell ◽  
In Vivo Imaging ◽  
Parp Inhibition

scholarly journals Single-cell in vivo imaging of adult neural stem cells in the zebrafish telencephalon

2016 ◽  
Vol 11 (8) ◽  
pp. 1360-1370 ◽  
Author(s):  
Joana S Barbosa ◽  
Rossella Di Giaimo ◽  
Magdalena Götz ◽  
Jovica Ninkovic
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Single Cell ◽  
In Vivo Imaging ◽  
Adult Neural Stem Cells

scholarly journals In Vivo Imaging of Drug-Induced Mitochondrial Outer Membrane Permeabilization at Single-Cell Resolution

2012 ◽  
Vol 72 (12) ◽  
pp. 2949-2956 ◽  
Author(s):  
Sarah Earley ◽  
Claudio Vinegoni ◽  
Joshua Dunham ◽  
Rostic Gorbatov ◽  
Paolo Fumene Feruglio ◽  
...  
Keyword(s):  
Single Cell ◽  
Outer Membrane ◽  
In Vivo Imaging ◽  
Membrane Permeabilization ◽  
Mitochondrial Outer Membrane ◽  
Drug Induced ◽  
Mitochondrial Outer Membrane Permeabilization
Sign in / Sign up

Export Citation Format

Share Document