scholarly journals A generic cell surface ligand system for studying cell–cell recognition

PLoS Biology ◽  
2019 ◽  
Vol 17 (12) ◽  
pp. e3000549 ◽  
Author(s):  
Eleanor M. Denham ◽  
Michael I. Barton ◽  
Susannah M. Black ◽  
Marcus J. Bridge ◽  
Ben de Wet ◽  
...  
Keyword(s):  
Cell Surface ◽  
Cell Recognition ◽  
Ligand System ◽  
Surface Ligand ◽  
Cell Cell

scholarly journals A generic cell surface ligand system for studying cell-cell recognition

2019 ◽  
Author(s):  
Eleanor M Denham ◽  
Michael I Barton ◽  
Susannah M Black ◽  
Marcus J Bridge ◽  
Ben de Wet ◽  
...  
Keyword(s):  
Cell Surface ◽  
Surface Density ◽  
Cell Receptor ◽  
Surface Receptors ◽  
Ligand System ◽  
Ligand Interactions ◽  
A Cell ◽  
Surface Ligand ◽  
Receptor Biology ◽  
Cell Cell

AbstractDose-response experiments are a mainstay of receptor biology studies and can reveal valuable insights into receptor function. Such studies of receptors that bind cell surface ligands are currently limited by the difficulty in manipulating the surface density of ligands at a cell-cell interface. Here we describe a generic cell surface ligand system that allows precise manipulation of cell surface ligand densities over several orders of magnitude. We validate the system for a range of immunoreceptors, including the T cell receptor (TCR), and show that this generic ligand stimulates via the TCR at a similar surface density as its native ligand. This system allows the effect of surface density, valency, dimensions, and affinity of the ligand to be manipulated. It can be readily extended to other receptor-cell surface ligand interactions, and will facilitate investigation into the activation of, and signal integration between, cell surface receptors.

Cell surface changes associated with the loss of cell-cell recognition in Neurospora

1979 ◽  
Vol 3 (4) ◽  
pp. 363-373 ◽  
Author(s):  
Claude P. Selitrennikoff ◽  
Sandra Elson Slemmer ◽  
Robert E. Nelson
Keyword(s):  
Cell Surface ◽  
Cell Recognition ◽  
Cell Surface Changes ◽  
Surface Changes ◽  
Cell Cell

scholarly journals Keratin 19 maintains E-cadherin localization at the cell surface and stabilizes cell-cell adhesion of MCF7 cells

2021 ◽  
Vol 15 (1) ◽  
pp. 1-17
Author(s):  
Sarah Alsharif ◽  
Pooja Sharma ◽  
Karina Bursch ◽  
Rachel Milliken ◽  
Van Lam ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Cell Surface ◽  
Mcf7 Cells ◽  
Keratin 19 ◽  
E Cadherin ◽  
Cell Cell

The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3

Nature ◽  
1987 ◽  
Vol 326 (6111) ◽  
pp. 400-403 ◽  
Author(s):  
Periasamy Selvaraj ◽  
Marian L. Plunkett ◽  
Michael Dustin ◽  
Martin E. Sanders ◽  
Stephen Shaw ◽  
...  
Keyword(s):  
Cell Surface ◽  
T Lymphocyte ◽  
Surface Ligand

Factors mediating cell-cell recognition and adhesion

FEBS Letters ◽  
1980 ◽  
Vol 122 (2) ◽  
pp. 157-165 ◽  
Author(s):  
F.Lynne Harrison ◽  
C.James Chesterton
Keyword(s):  
Cell Recognition ◽  
Cell Cell
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