scholarly journals Correction: Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells

PLoS Biology ◽  
2016 ◽  
Vol 14 (1) ◽  
pp. e1002367 ◽  
Author(s):  
Jinlong Yin ◽  
Gunwoo Park ◽  
Tae Hoon Kim ◽  
Jun Hee Hong ◽  
Youn-Jae Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tumor Progression ◽  
Pigment Epithelium ◽  
Glioma Stem Cells ◽  
Self Renewal ◽  
Pigment Epithelium Derived Factor

scholarly journals Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells

PLoS Biology ◽  
2015 ◽  
Vol 13 (5) ◽  
pp. e1002152 ◽  
Author(s):  
Jinlong Yin ◽  
Gunwoo Park ◽  
Tae Hoon Kim ◽  
Jun Hee Hong ◽  
Youn-Jae Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tumor Progression ◽  
Pigment Epithelium ◽  
Glioma Stem Cells ◽  
Self Renewal ◽  
Pigment Epithelium Derived Factor

scholarly journals Hostile Takeover: Glioma Stem Cells Recruit TAMs to Support Tumor Progression

2015 ◽  
Vol 16 (3) ◽  
pp. 219-220 ◽  
Author(s):  
Yu Shi ◽  
Yi-fang Ping ◽  
Xia Zhang ◽  
Xiu-wu Bian
Keyword(s):  
Stem Cells ◽  
Tumor Progression ◽  
Glioma Stem Cells ◽  
Hostile Takeover

MicroRNA‐30a suppresses self‐renewal and tumorigenicity of glioma stem cells by blocking the NT5E‐dependent Akt signaling pathway

2020 ◽  
Vol 34 (4) ◽  
pp. 5128-5143
Author(s):  
Lilei Peng ◽  
Yang Ming ◽  
Ling Zhang ◽  
Jie Zhou ◽  
Wei Xiang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Glioma Stem Cells ◽  
Akt Signaling Pathway ◽  
Self Renewal

scholarly journals HAUSP Stabilizes SOX2 through Deubiquitination to Maintain Self-renewal and Tumorigenic Potential of Glioma Stem Cells

2021 ◽  
Author(s):  
Zhi Huang ◽  
Kui Zhai ◽  
Qiulian Wu ◽  
Xiaoguang Fang ◽  
Qian Huang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Glioma Stem Cells ◽  
Posttranslational Regulation ◽  
Malignant Growth ◽  
Self Renewal ◽  
Animal Survival ◽  
Promising Target ◽  
Tumorigenic Potential ◽  
Therapeutic Opportunity

Glioblastoma (GBM) is the most lethal brain tumor containing glioma stem cells (GSCs) that promote malignant growth and therapeutic resistance. The self-renewal and tumorigenic potential of GSCs are maintained by core stem cell transcription factors including SOX2. Defining the posttranslational regulation of SOX2 may offer new insights into GSC biology and potential therapeutic opportunity. Here, we discover that HAUSP stabilizes SOX2 through deubiquitination to maintain GSC self-renewal and tumorigenic potential. HAUSP is preferentially expressed in GSCs in perivascular niches in GBMs. Disrupting HAUSP by shRNA or its inhibitor P22077 promoted SOX2 degradation, induced GSC differentiation, impaired GSC tumorigenic potential, and suppressed GBM tumor growth. Importantly, pharmacological inhibition of HAUSP synergized with radiation to inhibit GBM growth and extended animal survival, indicating that targeting HAUSP may overcome GSC-mediated radioresistance. Our findings reveal an unappreciated crucial role of HAUSP in the GSC maintenance and provide a promising target for developing effective anti-GSC therapeutics to improve GBM treatment.

scholarly journals Functional IL-17R in glioma stem cells: potential role in tumor progression and therapeutic implications

2015 ◽  
Vol 3 (S2) ◽  
Author(s):  
Prahlad Parajuli ◽  
Rohit Anand ◽  
Chandramouli Mandalaparty ◽  
Raviteja Suryadevara ◽  
Preethi Sriranga ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tumor Progression ◽  
Potential Role ◽  
Glioma Stem Cells ◽  
Therapeutic Implications

scholarly journals Nrf2 is required to maintain the self-renewal of glioma stem cells

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Jianhong Zhu ◽  
Handong Wang ◽  
Qing Sun ◽  
Xiangjun Ji ◽  
Lin Zhu ◽  
...  
Keyword(s):  
Stem Cells ◽  
The Self ◽  
Glioma Stem Cells ◽  
Self Renewal

The roles of nanocarriers on pigment epithelium-derived factor in the differentiation of human cardiac stem cells

2015 ◽  
Vol 362 (3) ◽  
pp. 611-621 ◽  
Author(s):  
Hongliang Liang ◽  
Weixun Duan ◽  
Huiyuan Hou ◽  
Wei Yi ◽  
Jinzhou Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Pigment Epithelium ◽  
Cardiac Stem Cells ◽  
Pigment Epithelium Derived Factor

scholarly journals Neurotrophic Effect of Adipose Tissue-Derived Stem Cells on Erectile Function Recovery by Pigment Epithelium-Derived Factor Secretion in a Rat Model of Cavernous Nerve Injury

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Xin Chen ◽  
Qiyun Yang ◽  
Tao Zheng ◽  
Jun Bian ◽  
Xiangzhou Sun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Nerve Injury ◽  
Erectile Function ◽  
Pigment Epithelium ◽  
Intracavernous Injection ◽  
Cavernous Nerve ◽  
Pigment Epithelium Derived Factor ◽  
Cavernous Nerve Injury

The paracrine effect is the major mechanism of stem cell therapy. However, the details of the effect’s mechanism remain unknown. The aim of this study is to investigate whether adipose tissue-derived stem cells (ADSCs) can ameliorate cavernous nerve injury-induced erectile dysfunction (CNIED) rats and to determine its mechanism. Twenty-eight days after intracavernous injection of 5-ethynyl-2-deoxyuridine- (EdU-) labeled ADSCs, the erectile function of all the rats was evaluated by intracavernosal pressure (ICP). The ADSCs steadily secreted detectable pigment epithelium-derived factor (PEDF)in vitro. The expression of PEDF increased in the penis of the bilateral cavernous nerve injury (BCNI) group for 14 days and then gradually decreased. On day 28 after the intracavernous injection, the ADSCs group exhibited a significantly increased ICP compared with the phosphate buffered saline- (PBS-) treated group. Moreover, the neuronal nitric oxide synthase (nNOS) and S100 expression in penile dorsal nerves and the smooth muscle content to collagen ratio in penile tissues significantly increased. Furthermore, elevated PEDF, p-Akt, and p-eNOS were identified in the ADSCs group. This study demonstrated that intracavernous injection of ADSCs improved erectile function, repaired the nerve, and corrected penile fibrosis. One potential mechanism is the PEDF secretion of ADSCs and subsequent PI3K/Akt pathway activation.

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