scholarly journals Pyramidal Cells Make Specific Connections onto Smooth (GABAergic) Neurons in Mouse Visual Cortex

PLoS Biology ◽  
2014 ◽  
Vol 12 (8) ◽  
pp. e1001932 ◽  
Author(s):  
Rita Bopp ◽  
Nuno Maçarico da Costa ◽  
Björn M. Kampa ◽  
Kevan A. C. Martin ◽  
Morgane M. Roth
Keyword(s):  
Visual Cortex ◽  
Pyramidal Cells ◽  
Gabaergic Neurons ◽  
Mouse Visual Cortex

scholarly journals A neural circuit for gamma-band coherence across the retinotopic map in mouse visual cortex

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Richard Hakim ◽  
Kiarash Shamardani ◽  
Hillel Adesnik
Keyword(s):  
Visual Cortex ◽  
Neural Circuit ◽  
Brain Slices ◽  
Pyramidal Cells ◽  
Gamma Oscillations ◽  
Gamma Band ◽  
Neuron Activity ◽  
Mouse Visual Cortex ◽  
Retinotopic Map

Cortical gamma oscillations have been implicated in a variety of cognitive, behavioral, and circuit-level phenomena. However, the circuit mechanisms of gamma-band generation and synchronization across cortical space remain uncertain. Using optogenetic patterned illumination in acute brain slices of mouse visual cortex, we define a circuit composed of layer 2/3 (L2/3) pyramidal cells and somatostatin (SOM) interneurons that phase-locks ensembles across the retinotopic map. The network oscillations generated here emerge from non-periodic stimuli, and are stimulus size-dependent, coherent across cortical space, narrow band (30 Hz), and depend on SOM neuron but not parvalbumin (PV) neuron activity; similar to visually induced gamma oscillations observed in vivo. Gamma oscillations generated in separate cortical locations exhibited high coherence as far apart as 850 μm, and lateral gamma entrainment depended on SOM neuron activity. These data identify a circuit that is sufficient to mediate long-range gamma-band coherence in the primary visual cortex.

scholarly journals 3D Clustering of GABAergic Neurons Enhances Inhibitory Actions on Excitatory Neurons in the Mouse Visual Cortex

Cell Reports ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. 1896-1907 ◽  
Author(s):  
Teppei Ebina ◽  
Kazuhiro Sohya ◽  
Itaru Imayoshi ◽  
Shu-Ting Yin ◽  
Rui Kimura ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Gabaergic Neurons ◽  
Excitatory Neurons ◽  
Mouse Visual Cortex

scholarly journals Opposing forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits and gated by locomotion

2020 ◽  
Author(s):  
Tristan G. Heintz ◽  
Antonio J. Hinojosa ◽  
Leon Lagnado
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Internal State ◽  
Pyramidal Cells ◽  
External World ◽  
Neural Circuitry ◽  
Cortical Processing ◽  
Locomotor Behaviour ◽  
Different Types ◽  
Mouse Visual Cortex

SummaryCortical processing of sensory signals adjusts to changes in both the external world and the internal state of the animal. We investigated the neural circuitry by which these processes interact in the primary visual cortex of mice. An increase in contrast caused as many pyramidal cells (PCs) to sensitize as depress, reflecting the dynamics of adaptation in different types of interneuron (PV, SST and VIP). Optogenetic manipulations demonstrate that the net effect within PCs reflects the balance of PV inputs, driving depression, and a subset of SST interneurons, driving sensitization. Locomotor behaviour increased the gain of PC responses by disinhibition through both the VIP->SST and SST->PV pathways, thereby maintaining the balance between opposing forms of plasticity. These experiments reveal how inhibitory microcircuits interact to purpose different subsets of PCs for the signalling of increases or decreases in contrast while also allowing for behavioural control of gain across the population.

scholarly journals GABAergic interneurons excite neonatal hippocampus in vivo

2020 ◽  
Vol 6 (24) ◽  
pp. eaba1430 ◽  
Author(s):  
Yasunobu Murata ◽  
Matthew T. Colonnese
Keyword(s):  
Visual Cortex ◽  
Synapse Formation ◽  
Reversal Potential ◽  
Pyramidal Cells ◽  
Gabaergic Neurons ◽  
Network Activity ◽  
Gabaergic Interneuron ◽  
Gabaergic Interneurons ◽  
Early Postnatal Development

GABAergic interneurons are proposed to be critical for early activity and synapse formation by directly exciting, rather than inhibiting, neurons in developing hippocampus and neocortex. However, the role of GABAergic neurons in the generation of neonatal network activity has not been tested in vivo, and recent studies have challenged the excitatory nature of early GABA. By locally manipulating interneuron activity in unanesthetized neonatal mice, we show that GABAergic neurons are excitatory in CA1 hippocampus at postnatal day 3 (P3) and are responsible for most of the spontaneous firing of pyramidal cells at that age. Hippocampal interneurons become inhibitory by P7, whereas visual cortex interneurons are already inhibitory by P3 and remain so throughout development. These regional and age-specific differences are the result of a change in chloride reversal potential, because direct activation of light-gated anion channels in glutamatergic neurons drives CA1 firing at P3, but silences it at P7 in CA1, and at all ages in visual cortex. This study in the intact brain reveals that GABAergic interneuron excitation is essential for network activity in neonatal hippocampus and confirms that visual cortical interneurons are inhibitory throughout early postnatal development.

AMPA GluR2 subunit is differentially distributed on GABAergic neurons and pyramidal cells in the macaque monkey visual cortex

2001 ◽  
Vol 921 (1-2) ◽  
pp. 60-67 ◽  
Author(s):  
Yong He ◽  
Patrick R Hof ◽  
William G.M Janssen ◽  
Prabhakar Vissavajjhala ◽  
John H Morrison
Keyword(s):  
Visual Cortex ◽  
Pyramidal Cells ◽  
Macaque Monkey ◽  
Gabaergic Neurons ◽  
Monkey Visual Cortex

Three-dimensional clusters of functional GABAergic neurons in the mouse visual cortex

2010 ◽  
Vol 68 ◽  
pp. e152-e153
Author(s):  
Teppei Ebina ◽  
Kazuhiro Sohya ◽  
Yuchio Yanagawa ◽  
Tadaharu Tsumoto
Keyword(s):  
Visual Cortex ◽  
Three Dimensional ◽  
Gabaergic Neurons ◽  
Mouse Visual Cortex

scholarly journals Vision and locomotion shape the interactions between neuron types in mouse visual cortex

2016 ◽  
Author(s):  
Mario Dipoppa ◽  
Adam Ranson ◽  
Michael Krumin ◽  
Marius Pachitariu ◽  
Matteo Carandini ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Pyramidal Cells ◽  
Cell Types ◽  
Synaptic Connectivity ◽  
Cortical Function ◽  
Cell Responses ◽  
Layer 2 ◽  
Measured Activity ◽  
Sensory Responses ◽  
Mouse Visual Cortex

SummaryIn the mouse primary visual cortex (V1), sensory responses are shaped by behavioral factors such as locomotion. These factors are thought to control a disinhibitory circuit, whereby interneurons expressing vasoactive intestinal peptide (Vip) inhibit those expressing somatostatin (Sst), disinhibiting pyramidal cells (Pyr). We measured the effect of locomotion on these neurons and on interneurons expressing parvalbumin (Pvalb) in layer 2/3 of mouse V1, and found in-consistencies with the disinhibitory model. In the presence of large stimuli, locomotion increased Sst cell responses without suppressing Vip cells. In the presence of small stimuli, locomotion increased Vip cell responses without suppressing Sst cells. A circuit model could reproduce each cell type’s activity from the measured activity of other cell types, but only if we allowed locomotion to increase feedforward synaptic weights while modulating recurrent weights. These results suggest that locomotion alters cortical function by changing effective synaptic connectivity, rather than only through disinhibition.

Sign in / Sign up

Export Citation Format

Share Document