The Cryo-EM Structure of a Complete 30S Translation Initiation Complex from Escherichia coli

Patricia Julián; Pohl Milon; Xabier Agirrezabala; Gorka Lasso; David Gil; Marina V. Rodnina; Mikel Valle

doi:10.1371/journal.pbio.1001095

The Cryo-EM Structure of a Complete 30S Translation Initiation Complex from Escherichia coli

PLoS Biology ◽

10.1371/journal.pbio.1001095 ◽

2011 ◽

Vol 9 (7) ◽

pp. e1001095 ◽

Cited By ~ 79

Author(s):

Patricia Julián ◽

Pohl Milon ◽

Xabier Agirrezabala ◽

Gorka Lasso ◽

David Gil ◽

...

Keyword(s):

Escherichia Coli ◽

Translation Initiation ◽

Initiation Complex

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The Cryo-EM Structure of a Translation Initiation Complex from Escherichia coli

Cell ◽

10.1016/j.cell.2005.03.023 ◽

2005 ◽

Vol 121 (5) ◽

pp. 703-712 ◽

Cited By ~ 204

Author(s):

Gregory S. Allen ◽

Andrey Zavialov ◽

Richard Gursky ◽

Måns Ehrenberg ◽

Joachim Frank

Keyword(s):

Escherichia Coli ◽

Translation Initiation ◽

Initiation Complex

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The Cryo-EM Structure of a Translation Initiation Complex from Escherichia coli

Series in Structural Biology - Single-Particle Cryo-Electron Microscopy ◽

10.1142/9789813234864_0037 ◽

2018 ◽

pp. 373-382

Author(s):

Gregory S. Allen ◽

Andrey Zavialov ◽

Richard Gursky ◽

Måns Ehrenberg ◽

Joachim Frank

Keyword(s):

Escherichia Coli ◽

Translation Initiation ◽

Initiation Complex

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ATP activation of DNA polymerase III holoenzyme of Escherichia coli. I. ATP-dependent formation of an initiation complex with a primed template.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)33783-9 ◽

1982 ◽

Vol 257 (19) ◽

pp. 11468-11473 ◽

Cited By ~ 28

Author(s):

P M Burgers ◽

A Kornberg

Keyword(s):

Escherichia Coli ◽

Dna Polymerase ◽

Dna Polymerase Iii ◽

Initiation Complex ◽

Polymerase Iii

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Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin

Genes & Development ◽

10.1101/gad.1817109 ◽

2009 ◽

Vol 23 (21) ◽

pp. 2537-2550 ◽

Cited By ~ 55

Author(s):

H. Sato ◽

L. E. Maquat

Keyword(s):

Translation Initiation ◽

Initiation Complex

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Communication between Eukaryotic Translation Initiation Factors 5 and 1A within the Ribosomal Pre-initiation Complex Plays a Role in Start Site Selection

Journal of Molecular Biology ◽

10.1016/j.jmb.2005.11.083 ◽

2006 ◽

Vol 356 (3) ◽

pp. 724-737 ◽

Cited By ~ 57

Author(s):

David Maag ◽

Mikkel A. Algire ◽

Jon R. Lorsch

Keyword(s):

Translation Initiation ◽

Site Selection ◽

Start Site ◽

Initiation Complex ◽

Eukaryotic Translation ◽

Initiation Factors ◽

Translation Initiation Factors ◽

Eukaryotic Translation Initiation ◽

Eukaryotic Translation Initiation Factors

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Mutually exclusive RNA secondary structures regulate translation initiation of DinQ in Escherichia coli

RNA ◽

10.1261/rna.058461.116 ◽

2016 ◽

Vol 22 (11) ◽

pp. 1739-1749 ◽

Cited By ~ 10

Author(s):

Knut I. Kristiansen ◽

Ragnhild Weel-Sneve ◽

James A. Booth ◽

Magnar Bjørås

Keyword(s):

Escherichia Coli ◽

Translation Initiation ◽

Secondary Structures ◽

Rna Secondary Structures

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Unfolding of mRNA Secondary Structure by the Bacterial Translation Initiation Complex

Molecular Cell ◽

10.1016/j.molcel.2006.02.014 ◽

2006 ◽

Vol 22 (1) ◽

pp. 105-115 ◽

Cited By ~ 117

Author(s):

Sean M. Studer ◽

Simpson Joseph

Keyword(s):

Secondary Structure ◽

Translation Initiation ◽

Mrna Secondary Structure ◽

Initiation Complex ◽

Bacterial Translation Initiation ◽

Bacterial Translation

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Ribosomal Initiation Complex-Driven Changes in the Stability and Dynamics of Initiation Factor 2 Regulate the Fidelity of Translation Initiation

Journal of Molecular Biology ◽

10.1016/j.jmb.2014.12.025 ◽

2015 ◽

Vol 427 (9) ◽

pp. 1819-1834 ◽

Cited By ~ 17

Author(s):

Jiangning Wang ◽

Kelvin Caban ◽

Ruben L. Gonzalez

Keyword(s):

Translation Initiation ◽

Initiation Factor ◽

Initiation Complex ◽

Initiation Factor 2 ◽

The Stability

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2′-O-(2-Methoxy)ethyl-modified Anti-intercellular Adhesion Molecule 1 (ICAM-1) Oligonucleotides Selectively Increase the ICAM-1 mRNA Level and Inhibit Formation of the ICAM-1 Translation Initiation Complex in Human Umbilical Vein Endothelial Cells

Journal of Biological Chemistry ◽

10.1074/jbc.272.18.11994 ◽

1997 ◽

Vol 272 (18) ◽

pp. 11994-12000 ◽

Cited By ~ 223

Author(s):

Brenda F. Baker ◽

Sidney S. Lot ◽

Thomas P. Condon ◽

Shin Cheng-Flournoy ◽

Elena A. Lesnik ◽

...

Keyword(s):

Endothelial Cells ◽

Adhesion Molecule ◽

Translation Initiation ◽

Umbilical Vein ◽

Mrna Level ◽

Intercellular Adhesion Molecule ◽

Intercellular Adhesion Molecule 1 ◽

Initiation Complex ◽

Human Umbilical Vein ◽

Umbilical Vein Endothelial Cells

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Leaderless mRNAs Bind 70S Ribosomes More Strongly than 30S Ribosomal Subunits in Escherichia coli

Journal of Bacteriology ◽

10.1128/jb.184.23.6730-6733.2002 ◽

2002 ◽

Vol 184 (23) ◽

pp. 6730-6733 ◽

Cited By ~ 43

Author(s):

Sean M. O'Donnell ◽

Gary R. Janssen

Keyword(s):

Escherichia Coli ◽

Translation Initiation ◽

Primer Extension ◽

Ribosomal Subunits ◽

Ribosome Binding ◽

Initiation Factors ◽

Translation Initiation Factors

ABSTRACT By primer extension inhibition assays, 70S ribosomes bound with higher affinity, or stability, than did 30S subunits to leaderless mRNAs containing AUG or GUG start codons. Addition of translation initiation factors affected ribosome binding to leaderless mRNAs. Our results suggest that translation of leaderless mRNAs might initiate through a pathway involving 70S ribosomes or 30S subunits lacking IF3.

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