scholarly journals Unfolding of mRNA Secondary Structure by the Bacterial Translation Initiation Complex

2006 ◽  
Vol 22 (1) ◽  
pp. 105-115 ◽  
Author(s):  
Sean M. Studer ◽  
Simpson Joseph
Keyword(s):  
Secondary Structure ◽  
Translation Initiation ◽  
Mrna Secondary Structure ◽  
Initiation Complex ◽  
Bacterial Translation Initiation ◽  
Bacterial Translation

scholarly journals A Conserved Structural Motif at the N Terminus of Bacterial Translation Initiation Factor IF2

2003 ◽  
Vol 278 (18) ◽  
pp. 16320-16328 ◽  
Author(s):  
Brian Søgaard Laursen ◽  
Kim Kusk Mortensen ◽  
Hans Uffe Sperling-Petersen ◽  
David W. Hoffman
Keyword(s):  
Translation Initiation ◽  
Translation Initiation Factor ◽  
Structural Motif ◽  
Initiation Factor ◽  
N Terminus ◽  
Bacterial Translation Initiation ◽  
Bacterial Translation

The involvement of mRNA secondary structure in protein synthesis

1987 ◽  
Vol 65 (6) ◽  
pp. 576-581 ◽  
Author(s):  
Jerry Pelletier ◽  
Nahum Sonenberg
Keyword(s):  
Secondary Structure ◽  
Translation Initiation ◽  
Binding Proteins ◽  
Atp Hydrolysis ◽  
Mrna Translation ◽  
Noncoding Region ◽  
Translational Efficiency ◽  
Mrna Secondary Structure ◽  
Complex Process ◽  
Eukaryotic Mrnas

Translation initiation in eukaryotes is a complex process involving many factors. A key step in this process is the binding of mRNA to the 43S preinitiation complex. This is generally the rate-limiting step in translation initiation and consequently a major determinant of mRNA translational efficiency. The primary and secondary structure of the mRNA 5′ noncoding region have been implicated in modulating translational efficiency. Translational efficiency was shown to be inversely proportional to the degree of secondary structure at the mRNA 5′ noncoding region. Furthermore, it was shown that cap-binding proteins that interact with the 5′ cap structure (m7GpppN) of eukaryotic mRNAs are involved in the "unwinding" of the mRNA secondary structure, in an ATP hydrolysis mediated event, to facilitate ribosome binding. Thus, cap-binding proteins can potentially regulate mRNA translation. Here, we discuss the available data supporting the notion that eukaryotic 5′ mRNA secondary structure plays an important role in translation initiation and the possible regulation of this process.

Mapping the Active Sites of Bacterial Translation Initiation Factor IF3

2003 ◽  
Vol 331 (3) ◽  
pp. 541-556 ◽  
Author(s):  
Dezemona Petrelli ◽  
Cristiana Garofalo ◽  
Matilde Lammi ◽  
Roberto Spurio ◽  
Cynthia L Pon ◽  
...  
Keyword(s):  
Translation Initiation ◽  
Active Sites ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Bacterial Translation Initiation ◽  
Bacterial Translation

scholarly journals Ribosome signatures aid bacterial translation initiation site identification

BMC Biology ◽  
2017 ◽  
Vol 15 (1) ◽  
Author(s):  
Adam Giess ◽  
Veronique Jonckheere ◽  
Elvis Ndah ◽  
Katarzyna Chyżyńska ◽  
Petra Van Damme ◽  
...  
Keyword(s):  
Translation Initiation ◽  
Initiation Site ◽  
Translation Initiation Site ◽  
Site Identification ◽  
Bacterial Translation Initiation ◽  
Bacterial Translation
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