scholarly journals Obtaining Consent for Future Research with Induced Pluripotent Cells: Opportunities and Challenges

PLoS Biology ◽  
2009 ◽  
Vol 7 (2) ◽  
pp. e1000042 ◽  
Author(s):  
Katriina Aalto-Setälä ◽  
Bruce R Conklin ◽  
Bernard Lo
Keyword(s):  
Future Research ◽  
Pluripotent Cells ◽  
Induced Pluripotent Cells ◽  
Induced Pluripotent

scholarly journals Questioned validity of Gene Expression Dysregulated Domains in Down's Syndrome

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 269 ◽  
Author(s):  
Long H. Do ◽  
William C. Mobley ◽  
Nishant Singhal
Keyword(s):  
Gene Expression ◽  
Monozygotic Twins ◽  
Recent Analysis ◽  
Ts65dn Mouse ◽  
Pluripotent Cells ◽  
Induced Pluripotent Cells ◽  
Independent Analysis ◽  
Human Ipscs ◽  
Rnaseq Data ◽  
Induced Pluripotent

Recently, in studies examining fibroblasts obtained from the tissues of one set of monozygotic twins (i.e. fetuses derived from the same egg) discordant for trisomy 21 (Down syndrome; DS), Letourneau et al., reported the presence of a defined pattern of dysregulation within specific genomic domains they referred to as Gene Expression Dysregulated Domains (GEDDs). GEDDs were described as alternating segments of increased or decreased gene expression affecting all chromosomes. Strikingly, GEDDs in fibroblasts were largely conserved in induced pluripotent cells (iPSCs) generated from the twin’s fibroblasts as well as in fibroblasts from the Ts65Dn mouse model of DS. Our recent analysis failed to find GEDDs. We reexamined the human iPSCs RNAseq data from Letourneau et al., and data from this same research group published earlier examining iPSCs from the same monozygotic twins. An independent analysis of RNAseq data from Ts65Dn fibroblasts also failed to confirm presence of GEDDs. Our analysis questions the validity of GEDDs in DS.

scholarly journals A defined culture method enabling the establishment of ring sideroblasts from induced pluripotent cells of X-linked sideroblastic anemia

Haematologica ◽  
2018 ◽  
Vol 103 (5) ◽  
pp. e188-e191 ◽  
Author(s):  
Shunsuke Hatta ◽  
Tohru Fujiwara ◽  
Takako Yamamoto ◽  
Kei Saito ◽  
Mayumi Kamata ◽  
...  
Keyword(s):  
Culture Method ◽  
Pluripotent Cells ◽  
Sideroblastic Anemia ◽  
Induced Pluripotent Cells ◽  
Ring Sideroblasts ◽  
Induced Pluripotent ◽  
Defined Culture

scholarly journals Histone Deacetylase 1 Deficiency Impairs Differentiation and Electrophysiological Properties of Cardiomyocytes Derived from Induced Pluripotent Cells

Stem Cells ◽  
2012 ◽  
Vol 30 (11) ◽  
pp. 2412-2422 ◽  
Author(s):  
Eneda Hoxha ◽  
Erin Lambers ◽  
Hehuang Xie ◽  
Alexandre De Andrade ◽  
Prasanna Krishnamurthy ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Pluripotent Cells ◽  
Electrophysiological Properties ◽  
Histone Deacetylase 1 ◽  
Induced Pluripotent Cells ◽  
Induced Pluripotent

CRISPR/Cas9 Nuclease-Mediated Gene Knock-In in Bovine-Induced Pluripotent Cells

2015 ◽  
Vol 24 (3) ◽  
pp. 393-402 ◽  
Author(s):  
Young Tae Heo ◽  
Xiaoyuan Quan ◽  
Yong Nan Xu ◽  
Soonbong Baek ◽  
Hwan Choi ◽  
...  
Keyword(s):  
Pluripotent Cells ◽  
Induced Pluripotent Cells ◽  
Cas9 Nuclease ◽  
Induced Pluripotent

CC Chemokine Ligand 2 and Leukemia Inhibitory Factor Cooperatively Promote Pluripotency in Mouse Induced Pluripotent Cells

Stem Cells ◽  
2011 ◽  
Vol 29 (8) ◽  
pp. 1196-1205 ◽  
Author(s):  
Yuki Hasegawa ◽  
Naoko Takahashi ◽  
Alistair R. R. Forrest ◽  
Jay W. Shin ◽  
Yohei Kinoshita ◽  
...  
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Inhibitory Factor ◽  
Pluripotent Cells ◽  
Cc Chemokine ◽  
Induced Pluripotent Cells ◽  
Chemokine Ligand ◽  
Induced Pluripotent ◽  
Cc Chemokine Ligand 2 ◽  
Chemokine Ligand 2

Genetic manipulations and examination of differentiation properties of rat induced pluripotent cells

2012 ◽  
Vol 6 (2) ◽  
pp. 122-127
Author(s):  
M. A. Liskovykh ◽  
I. A. Chuykin ◽  
A. Ranjan ◽  
E. Popova ◽  
E. N. Tolkunova ◽  
...  
Keyword(s):  
Pluripotent Cells ◽  
Genetic Manipulations ◽  
Induced Pluripotent Cells ◽  
Induced Pluripotent
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