scholarly journals Correction: Dynamic Remodeling of Dendritic Arbors in GABAergic Interneurons of Adult Visual Cortex

PLoS Biology ◽  
2006 ◽  
Vol 4 (5) ◽  
pp. e126 ◽  
Author(s):  
Wei-Chung Allen Lee ◽  
Hayden Huang ◽  
Guoping Feng ◽  
Joshua R Sanes ◽  
Emery N Brown ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Gabaergic Interneurons ◽  
Dendritic Arbors

scholarly journals Dynamic Remodeling of Dendritic Arbors in GABAergic Interneurons of Adult Visual Cortex

PLoS Biology ◽  
2005 ◽  
Vol 4 (2) ◽  
pp. e29 ◽  
Author(s):  
Wei-Chung Allen Lee ◽  
Hayden Huang ◽  
Guoping Feng ◽  
Joshua R Sanes ◽  
Emery N Brown ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Gabaergic Interneurons ◽  
Dendritic Arbors

scholarly journals Aberrant development of excitatory circuits to inhibitory neurons in the primary visual cortex after neonatal binocular enucleation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Rongkang Deng ◽  
Joseph P. Y. Kao ◽  
Patrick O. Kanold
Keyword(s):  
Visual Cortex ◽  
Nmda Receptors ◽  
Laser Scanning ◽  
Inhibitory Neurons ◽  
Gabaergic Interneurons ◽  
Cortical Circuits ◽  
Retinal Input ◽  
Layer 4 ◽  
Ampa And Nmda Receptors ◽  
Laser Scanning Photostimulation

AbstractThe development of GABAergic interneurons is important for the functional maturation of cortical circuits. After migrating into the cortex, GABAergic interneurons start to receive glutamatergic connections from cortical excitatory neurons and thus gradually become integrated into cortical circuits. These glutamatergic connections are mediated by glutamate receptors including AMPA and NMDA receptors and the ratio of AMPA to NMDA receptors decreases during development. Since previous studies have shown that retinal input can regulate the early development of connections along the visual pathway, we investigated if the maturation of glutamatergic inputs to GABAergic interneurons in the visual cortex requires retinal input. We mapped the spatial pattern of glutamatergic connections to layer 4 (L4) GABAergic interneurons in mouse visual cortex at around postnatal day (P) 16 by laser-scanning photostimulation and investigated the effect of binocular enucleations at P1/P2 on these patterns. Gad2-positive interneurons in enucleated animals showed an increased fraction of AMPAR-mediated input from L2/3 and a decreased fraction of input from L5/6. Parvalbumin-expressing (PV) interneurons showed similar changes in relative connectivity. NMDAR-only input was largely unchanged by enucleation. Our results show that retinal input sculpts the integration of interneurons into V1 circuits and suggest that the development of AMPAR- and NMDAR-only connections might be regulated differently.

scholarly journals Distinct maturation profiles of perisomatic and dendritic targeting GABAergic interneurons in the mouse primary visual cortex during the critical period of ocular dominance plasticity

2011 ◽  
Vol 106 (2) ◽  
pp. 775-787 ◽  
Author(s):  
Matthew S. Lazarus ◽  
Z. Josh Huang
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Fluorescent Protein ◽  
Ocular Dominance ◽  
Input Resistance ◽  
Resting Membrane Potential ◽  
Gabaergic Interneurons ◽  
Inhibitory Circuitry ◽  
Cortical Interneurons ◽  
Fast Spiking

In the rodent primary visual cortex, maturation of GABA inhibitory circuitry is regulated by visual input and contributes to the onset and progression of ocular dominance (OD) plasticity. Cortical inhibitory circuitry consists of diverse groups of GABAergic interneurons, which display distinct physiological properties and connectivity patterns. Whether different classes of interneurons mature with similar or distinct trajectories and how their maturation profiles relate to experience dependent development are not well understood. We used green fluorescent protein reporter lines to study the maturation of two broad classes of cortical interneurons: parvalbumin-expressing (PV) cells, which are fast spiking and innervate the soma and proximal dendrites, and somatostatin-expressing (SOM) cells, which are regular spiking and target more distal dendrites. Both cell types demonstrate extensive physiological maturation, but with distinct trajectories, from eye opening to the peak of OD plasticity. Typical fast-spiking characteristics of PV cells became enhanced, and synaptic signaling from PV to pyramidal neurons became faster. SOM cells demonstrated a large increase in input resistance and a depolarization of resting membrane potential, resulting in increased excitability. While the substantial maturation of PV cells is consistent with the importance of this source of inhibition in triggering OD plasticity, the significant increase in SOM cell excitability suggests that dendrite-targeted inhibition may also play a role in OD plasticity. More generally, these results underscore the necessity of cell type-based analysis and demonstrate that distinct classes of cortical interneurons have markedly different developmental profiles, which may contribute to the progressive emergence of distinct functional properties of cortical circuits.

scholarly journals GABAergic interneurons excite neonatal hippocampus in vivo

2020 ◽  
Vol 6 (24) ◽  
pp. eaba1430 ◽  
Author(s):  
Yasunobu Murata ◽  
Matthew T. Colonnese
Keyword(s):  
Visual Cortex ◽  
Synapse Formation ◽  
Reversal Potential ◽  
Pyramidal Cells ◽  
Gabaergic Neurons ◽  
Network Activity ◽  
Gabaergic Interneuron ◽  
Gabaergic Interneurons ◽  
Early Postnatal Development

GABAergic interneurons are proposed to be critical for early activity and synapse formation by directly exciting, rather than inhibiting, neurons in developing hippocampus and neocortex. However, the role of GABAergic neurons in the generation of neonatal network activity has not been tested in vivo, and recent studies have challenged the excitatory nature of early GABA. By locally manipulating interneuron activity in unanesthetized neonatal mice, we show that GABAergic neurons are excitatory in CA1 hippocampus at postnatal day 3 (P3) and are responsible for most of the spontaneous firing of pyramidal cells at that age. Hippocampal interneurons become inhibitory by P7, whereas visual cortex interneurons are already inhibitory by P3 and remain so throughout development. These regional and age-specific differences are the result of a change in chloride reversal potential, because direct activation of light-gated anion channels in glutamatergic neurons drives CA1 firing at P3, but silences it at P7 in CA1, and at all ages in visual cortex. This study in the intact brain reveals that GABAergic interneuron excitation is essential for network activity in neonatal hippocampus and confirms that visual cortical interneurons are inhibitory throughout early postnatal development.

scholarly journals Experience-Dependent Development of Dendritic Arbors in Mouse Visual Cortex

2020 ◽  
Vol 40 (34) ◽  
pp. 6536-6556
Author(s):  
Sarah E.V. Richards ◽  
Anna R. Moore ◽  
Alice Y. Nam ◽  
Shikhar Saxena ◽  
Suzanne Paradis ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Dependent Development ◽  
Dendritic Arbors ◽  
Mouse Visual Cortex

scholarly journals Transplantation of GABAergic Interneurons into the Neonatal Primary Visual Cortex Reduces Absence Seizures in Stargazer Mice

2014 ◽  
Vol 25 (9) ◽  
pp. 2970-2979 ◽  
Author(s):  
Mohamed Hammad ◽  
Stephen L. Schmidt ◽  
Xuying Zhang ◽  
Ryan Bray ◽  
Flavio Frohlich ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Gabaergic Interneurons ◽  
Absence Seizures

scholarly journals Long-range and local circuits for top-down modulation of visual cortex processing

Science ◽  
2014 ◽  
Vol 345 (6197) ◽  
pp. 660-665 ◽  
Author(s):  
Siyu Zhang ◽  
Min Xu ◽  
Tsukasa Kamigaki ◽  
Johnny Phong Hoang Do ◽  
Wei-Cheng Chang ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Long Range ◽  
Sensory Processing ◽  
Visual Discrimination ◽  
Aminobutyric Acid ◽  
Gabaergic Interneurons ◽  
Top Down ◽  
Response Increase ◽  
Local Circuits ◽  
Corticocortical Projections

Top-down modulation of sensory processing allows the animal to select inputs most relevant to current tasks. We found that the cingulate (Cg) region of the mouse frontal cortex powerfully influences sensory processing in the primary visual cortex (V1) through long-range projections that activate local γ-aminobutyric acid–ergic (GABAergic) circuits. Optogenetic activation of Cg neurons enhanced V1 neuron responses and improved visual discrimination. Focal activation of Cg axons in V1 caused a response increase at the activation site but a decrease at nearby locations (center-surround modulation). Whereas somatostatin-positive GABAergic interneurons contributed preferentially to surround suppression, vasoactive intestinal peptide-positive interneurons were crucial for center facilitation. Long-range corticocortical projections thus act through local microcircuits to exert spatially specific top-down modulation of sensory processing.

Associative pairing involving monocular stimulation selectively mobilizes a subclass of GABAergic interneurons in the mouse visual cortex

2009 ◽  
Vol 516 (6) ◽  
pp. 482-492 ◽  
Author(s):  
Monika Liguz-Lecznar ◽  
Wioletta J. Waleszczyk ◽  
Renata Zakrzewska ◽  
Jolanta Skangiel-Kramska ◽  
Malgorzata Kossut
Keyword(s):  
Visual Cortex ◽  
Gabaergic Interneurons ◽  
Monocular Stimulation ◽  
Mouse Visual Cortex
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