scholarly journals Disentangling Sub-Millisecond Processes within an Auditory Transduction Chain

PLoS Biology ◽  
2005 ◽  
Vol 3 (1) ◽  
pp. e8 ◽  
Author(s):  
Tim Gollisch ◽  
Andreas M. V Herz
Keyword(s):  
Auditory Transduction

Auditory Transduction

2016 ◽  
pp. 159-175
Author(s):  
Daniel F. Eberl ◽  
Azusa Kamikouchi ◽  
Joerg T. Albert
Keyword(s):  
Auditory Transduction

scholarly journals Mechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices

2022 ◽  
Author(s):  
Nurunisa Akyuz ◽  
K. Domenica Karavitaki ◽  
Bifeng Pan ◽  
Panos I. Tamvakologos ◽  
Kelly P. Brock ◽  
...  
Keyword(s):  
Conformational Changes ◽  
Hair Cells ◽  
Single Channel ◽  
Transmembrane Helices ◽  
Open Probability ◽  
Transmembrane Channel ◽  
Force Sensitivity ◽  
Electrophysiological Recordings ◽  
Auditory Transduction ◽  
Pore Lining

The transmembrane channel-like (TMC) 1 and 2 proteins play a central role in auditory transduction, forming ion channels that convert sound into electrical signals. However, the molecular mechanism of their gating remains unknown. Here, using predicted structural models as a guide, we probed the effects of twelve mutations on the mechanical gating of the transduction currents in native hair cells of Tmc1/2-null mice expressing virally introduced TMC1 variants. Whole-cell electrophysiological recordings revealed that mutations within the pore-lining transmembrane (TM) helices 4 and 6 modified gating, reducing the force sensitivity or shifting the open probability of the channels, or both. For some of the mutants, these changes were accompanied by a change in single-channel conductance. Our observations are in line with a model wherein conformational changes in the TM4 and TM6 helices are involved in the mechanical gating of the transduction channel.

scholarly journals SnapShot: Auditory Transduction

Neuron ◽  
2013 ◽  
Vol 80 (2) ◽  
pp. 536-536.e1 ◽  
Author(s):  
A.J. Hudspeth
Keyword(s):  
Auditory Transduction

scholarly journals Auditory transduction in the mouse

2007 ◽  
Vol 454 (5) ◽  
pp. 793-804 ◽  
Author(s):  
Lisa Grant ◽  
Paul A. Fuchs
Keyword(s):  
Auditory Transduction

scholarly journals Taurine Transporter dEAAT2 is Required for Auditory Transduction in Drosophila

2018 ◽  
Vol 34 (6) ◽  
pp. 939-950 ◽  
Author(s):  
Ying Sun ◽  
Yanyan Jia ◽  
Yifeng Guo ◽  
Fangyi Chen ◽  
Zhiqiang Yan
Keyword(s):  
Taurine Transporter ◽  
Auditory Transduction
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