Complete response characterization of ultrafast linear photonic devices

2009 ◽  
Vol 34 (21) ◽  
pp. 3418 ◽  
Author(s):  
Tobias Kampfrath ◽  
Daryl M. Beggs ◽  
Thomas F. Krauss ◽  
L. (Kobus) Kuipers
Keyword(s):  
Complete Response ◽  
Photonic Devices

Silicon photonic devices for mid-infrared applications

Nanophotonics ◽  
2014 ◽  
Vol 3 (4-5) ◽  
pp. 329-341 ◽  
Author(s):  
Raji Shankar ◽  
Marko Lončar
Keyword(s):  
Gas Sensing ◽  
Wavelength Region ◽  
Photonic Devices ◽  
Ring Resonators ◽  
Space Communications ◽  
Mid Infrared ◽  
Silicon Photonic ◽  
Processing Techniques ◽  
Silicon Based

AbstractThe mid-infrared (IR) wavelength region (2–20 µm) is of great interest for a number of applications, including trace gas sensing, thermal imaging, and free-space communications. Recently, there has been significant progress in developing a mid-IR photonics platform in Si, which is highly transparent in the mid-IR, due to the ease of fabrication and CMOS compatibility provided by the Si platform. Here, we discuss our group’s recent contributions to the field of silicon-based mid-IR photonics, including photonic crystal cavities in a Si membrane platform and grating-coupled high-quality factor ring resonators in a silicon-on-sapphire (SOS) platform. Since experimental characterization of microphotonic devices is especially challenging at the mid-IR, we also review our mid-IR characterization techniques in some detail. Additionally, pre- and post-processing techniques for improving device performance, such as resist reflow, Piranha clean/HF dip cycling, and annealing are discussed.

scholarly journals Characterization of glucocorticoid receptors in animal lymphoblastic disease: correlation with response to single-agent glucocorticoid treatment

Blood ◽  
1984 ◽  
Vol 63 (2) ◽  
pp. 380-383 ◽  
Author(s):  
R Bell ◽  
S Cotter ◽  
A Lillquist ◽  
S Sallan ◽  
R McCaffrey
Keyword(s):  
Glucocorticoid Receptors ◽  
Single Agent ◽  
Complete Response ◽  
Single Peak ◽  
Human Leukemia ◽  
Normal Pattern ◽  
Glucocorticoid Treatment ◽  
Normal Tissues ◽  
Low Salt

Abstract The clinical significance of initial DEAE chromatography of glucocorticoid binders in lymphoblastic disease was evaluated in an animal model. Domestic cats and dogs with lymphoblastic disease were treated with prednisone, 2 mg/kg/day, for 14 days, and the outcome of therapy was correlated with DEAE chromatograms of glucocorticoid binders, using 3H-triamcinolone as ligand. Six of 30 animals had a single-peak low-salt binder species, similar to that seen in a subset of human leukemia, and none of these responded. Of the 29 animals with chromatograms identical to normal tissues, 6 had a complete response and another 11 a partial response. This distribution of responders is statistically significant (p = 0.02). Thus, the leukemia-associated single-peak DEAE species appears to be associated with glucocorticoid resistance, as defined by clinical responsiveness. In contrast, the two- peak normal pattern is a necessary, but insufficient, criterion for defining responsive disease.

Cytogenetic and Molecular Characterization of Extramedullary Disease (EMD) in Patients (pts) with Acute Myeloid Leukemia (AML).

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 2592-2592
Author(s):  
Naveen Pemmaraju ◽  
Hagop M. Kantarjian ◽  
Kathy M. Tran ◽  
Syed M. Kazmi ◽  
Tapan M. Kadia ◽  
...  
Keyword(s):  
Overall Survival ◽  
Lymph Node ◽  
Molecular Characterization ◽  
Conflicts Of Interest ◽  
Complete Response ◽  
Neck Lymph Node ◽  
Total Group ◽  
Molecular Abnormalities ◽  
Organ Systems

Abstract Abstract 2592 Background: The phenomenon of EMD in pts with AML has been previously noted. However, little is known about the cytogenetic and molecular characterization of these pts in the modern era of AML prognostic cytogenetic and molecular markers. Methods: We conducted a retrospective review of 2,181 consecutive pts with AML who underwent induction chemotherapy and were treated at our institution from 2000–2011. All pts included in this analysis had histologically-proven EMD-AML. Chi-squared test was used to assess complete response (CR) probability and Kaplan-Meier method was used to assess CR duration and overall survival (OS) outcomes. Results: Overall, 1,120 pts underwent biopsies/tissue sampling during the study period to evaluate for EMD-AML. 244 pts (11% of total group, 22% of those biopsied) were diagnosed (dx) with histologically proven EMD. 47 pts (2% of total group, 4% of pts biopsied, 19% of EMD pts) had EMD-AML at multiple sites. Median age of AML dx was 57 years (range 14–82 years). 135 pts were male (55%). Baseline CBC parameters at AML dx: WBC 9.5 (0–433), platelets 53 (0–581), Hb 8.7 (0–15.6). Median blasts at baseline AML dx: Peripheral 22% (0–99%) and bone marrow 56% (0–98%). EMD occurred at all phases of AML therapy course, with majority of EMD dx occurring at or after time of relapse (n=112, 46%), followed by concomitant at AML dx (28%), during induction therapy (15%) and prior to AML dx (11%). EMD sites were found throughout all major organ systems (Table 1). The specific sites most commonly affected by EMD included skin (n=84), CSF (n=76), pleural fluid (n=41), ascitic fluid (n=7), abdominal wall soft tissue (n=6), pelvic/inguinal lymph node (n=6), stomach (n=5), liver (n=5), cervical/neck lymph node (n=5), and bone (n=5). Cytogenetic abnormalities and molecular mutations were frequent features of EMD pts (Table 2, Table 3). Pts with EMD (n=156, 64%) were more likely to achieve CR than pts without EMD (n=1079, 56%, p=0.01). For those pts with EMD, CR duration was 59.0 months (95% CI 54.8–63.2 months), which was longer than for pts without EMD (CR duration, 43.5 months, 95% CI 40.7–46.4 months, p<0.0001). Overall survival (OS) of EMD pts (30.9 months, 95% CI 25.3–36.6 months) was significantly less than OS of non-EMD pts (43.5 months, 95% CI 40.7–46.4 months, p=0.04). Conclusion: Incidence of EMD in AML pts is common (11%) and occurs at all phases of disease course. Almost every organ system/tissue demonstrates involvement with EMD AML. Cytogenetic and molecular abnormalities are commonly associated with EMD AML pts, with FLT3 mutation being the most common molecular abnormality in this cohort (30% of evaluable pts) and deletion of chromosome 7 being most common chromosomal abnormality (14% of pts). While pts with EMD-AML had significantly longer CR duration, interestingly these pts were noted to have significantly shorter OS in this analysis, suggesting the unique biologic and clinical features of this subset of AML pts. Disclosures: No relevant conflicts of interest to declare.

Transfer and characterization of silicon nanomembrane-based photonic devices on flexible polyimide substrate

2011 ◽  
Author(s):  
Xiaochuan Xu ◽  
Harish Subbaraman ◽  
Daniel Pham ◽  
Amir Hosseini ◽  
Xiaohui Lin ◽  
...  
Keyword(s):  
Photonic Devices ◽  
Polyimide Substrate ◽  
Silicon Nanomembrane

Simple method for manufacturing and optical characterization of tapered optical fibres

2016 ◽  
Vol 24 (4) ◽  
Author(s):  
A. Zakrzewski ◽  
A. Pięta ◽  
S. Patela
Keyword(s):  
Focal Length ◽  
Fdtd Method ◽  
Single Mode ◽  
Photonic Devices ◽  
Optical Fibres ◽  
Simple Method ◽  
Spot Diameter ◽  
Small Spot ◽  
Edge Method

AbstractPhotonic devices often use light delivered by a single-mode telecommunication fibre. However, as the diameter of the core of the optical fibre is of 10 microns, and the transverse dimensions of the photonic waveguides are usually micrometer or less, there is an issue of incompatibility. The problem may be solved by application of tapered optical fibres. For efficient light coupling, the taper should be prepared so as to create a beam of long focal length and small spot diameter in the focus. The article describes the design, fabrication and characterization of tapered optical fibres prepared with a fibre-optic fusion splicer. We modelled the tapers with FDTD method, for estimation of the influence of the tapered length and angle on the spot diameter and the focal length of an outgoing beam. We fabricated tapers from a standard single mode fibre by the Ericsson 995 PMfi- bre-optic fusion splicer. We planned the splicing technology so as to get the needed features of the beam. We planned a multistep fusion process, with optimized fusion current and fusion time. The experimental measurements of best tapered optical fibres were carried out by the knife-edge method.

scholarly journals Characterization of integrated photonic devices with minimum phase technique

2009 ◽  
Vol 17 (10) ◽  
pp. 8349 ◽  
Author(s):  
R. Halir ◽  
Í. Molina-Fernández ◽  
J. G. Wangüemert-Pérez ◽  
A. Ortega-Moñux ◽  
J. de-Oliva-Rubio ◽  
...  
Keyword(s):  
Photonic Devices ◽  
Minimum Phase

Review of finite-element characterization of photonic devices

2003 ◽  
Vol 50 (12) ◽  
pp. 1835-1848 ◽  
Author(s):  
M. Rajarajan ◽  
B. M. A. Rahman ◽  
T. Wongcharoen ◽  
C. Themistos ◽  
N. Somasiri ◽  
...  
Keyword(s):  
Finite Element ◽  
Photonic Devices

Femtosecond Laser Processing of Glass Materials for Assembly-Free Fabrication of Photonic Microsensors

2014 ◽  
Vol 90 ◽  
pp. 166-173 ◽  
Author(s):  
Lei Yuan ◽  
Xin Wei Lan ◽  
Jie Huang ◽  
Hai Xiao
Keyword(s):  
Femtosecond Laser ◽  
Laser Processing ◽  
Photonic Devices ◽  
Fused Silica ◽  
Femtosecond Laser Processing ◽  
Industry Applications ◽  
One Step ◽  
Photonic Sensors

Research and development in photonic micro/nanodevices and structures have experienced a significant growth in recent years, fueled by their broad applications as sensors for in situ measurement of a wide variety of physical, chemical and biological quantities. Recent advancement in ultrafast and ultra-intense pulsed laser technology has opened a new window of opportunity for one-step fabrication of micro-and even nanoscale 3D structures in various solid materials. When used for fabrication, fs lasers have many unique advantages such as negligible cracks, minimal heat-affected-zone, low recast, and high precision. These advantages enable the unique opportunity to fabricate integrated sensors with unprecedented performance, enhanced functionalities and improved robustness. This paper summarizes our recent research progresses in the understanding, design, fabrication, characterization of various photonic sensors for energy, defense, environmental, biomedical and industry applications. Femtosecond laser processing/ablation of various glass materials (fused silica, doped silica, sapphire, etc.) is discussed towards the goal of one-step fabrication of novel photonic sensors and new enabling photonic devices. A number of new photonic devices and sensors are also presented.

Active Photonic Crystal Devices in Self-Assembled Electro-Optic Polymeric Materials

2004 ◽  
Vol 817 ◽  
Author(s):  
J. Li ◽  
P. J. Neyman ◽  
M. Vercellino ◽  
J. R. Heflin ◽  
R. Duncan ◽  
...  
Keyword(s):  
Photonic Crystal ◽  
Polymeric Materials ◽  
Optical Characterization ◽  
Photonic Devices ◽  
Self Assembled Monolayers ◽  
Electro Optic ◽  
Assembled Monolayers ◽  
Novel Approaches ◽  
Self Assembled

AbstractPhotonic crystals (PC) offer novel approaches for integrated photonics by allowing the manipulation of light based on the photonic bandgap effect rather than internal-reflection mechanisms employed in traditional devices. Electro-optic polymers represent interesting possibilities for the development of devices leveraging control over the phase of a confined propagating wave. We here report on the development of such active photonic crystal technology in ionically self-assembled monolayers. The simulation of active photonic devices such as Mach-Zehnder interferometers and wavelength multiplexers is first presented. We then report on the synthesis and optical characterization of electro-optic films grown through the ISAM technique. We conclude by presenting the preliminary development of a nanofabrication platform that would enable the realization of active photonic devices in such materials.

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