scholarly journals The detection of GDF11 by using Ti3C2-MXene-based fiber SPR biosensor

2021 ◽  
Author(s):  
Chunlan Liu ◽  
Rui Wang ◽  
Yabin Shao ◽  
Chen Chen ◽  
Ping Wu ◽  
...  
Keyword(s):  
Spr Biosensor

Studies of gold nanorod-iron oxide nanohybrids for immunoassay based on SPR biosensor

Talanta ◽  
2014 ◽  
Vol 125 ◽  
pp. 29-35 ◽  
Author(s):  
Hua Zhang ◽  
Ying Sun ◽  
Shang Gao ◽  
Hanqi Zhang ◽  
Jia Zhang ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Gold Nanorod ◽  
Spr Biosensor

Design of an ultrasensitive SPR biosensor based on a graphene-MoS2 hybrid structure with a MgF2 prism

2018 ◽  
Vol 57 (14) ◽  
pp. 3639 ◽  
Author(s):  
Yuncai Feng ◽  
Youwen Liu ◽  
Jinghua Teng
Keyword(s):  
Hybrid Structure ◽  
Spr Biosensor

Binding Investigation of Integrin αvβ3 With Its Inhibitors by SPR Technology and Molecular Docking Simulation

2010 ◽  
Vol 15 (2) ◽  
pp. 131-137 ◽  
Author(s):  
Yaqin Liu ◽  
Yuanjiang Pan ◽  
Yuhong Xu
Keyword(s):  
Molecular Docking ◽  
Binding Sites ◽  
Structural Model ◽  
Docking Simulation ◽  
Integrin Αvβ3 ◽  
Equilibrium Dissociation Constant ◽  
Molecular Docking Simulation ◽  
Spr Biosensor ◽  
Inhibitor Discovery ◽  
Equilibrium Dissociation

Integrins play critical roles in the process of angiogenesis and are attractive targets for anticancer therapies. It is desirable to develop new types of small-molecule inhibitors of integrin. Herein, the binding features of several inhibitors to integrin αvβ3 have been studied by surface plasmon resonance (SPR) biosensor technology and molecular docking analyses. The SPR results indicated that the equilibrium dissociation constant (KD) values are evaluated for the inhibitors and showed that the KD value of cyclopeptide c-Lys is much lower than the reference molecule. In addition, the 3D structural model of integrin αvβ3 was generated according to the crystal structure of the integrin αvβ3 complex, and the molecular docking simulation analyses revealed that the predicted binding sites for the most active cyclopeptide c-Lys were consistent with the reported structure. These results thus implied that cyclopeptide c-Lys could be developed as a novel inhibitor for integrin αvβ3. The current work has potential for application in structure-based integrin αvβ3 inhibitor discovery.

Zinc oxide, gold and graphene-based surface plasmon resonance (SPR) biosensor for detection of pseudomonas like bacteria: A comparative study

Optik ◽  
2018 ◽  
Vol 172 ◽  
pp. 697-707 ◽  
Author(s):  
Angad S. Kushwaha ◽  
Anil Kumar ◽  
Rajeev Kumar ◽  
Monika Srivastava ◽  
S.K. Srivastava
Keyword(s):  
Zinc Oxide ◽  
Surface Plasmon Resonance ◽  
Comparative Study ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Spr Biosensor

scholarly journals Surface plasmon resonance biosensor for exosome detection based on reformative tyramine signal amplification activated by molecular aptamer beacon

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Wenqin Chen ◽  
Zhiyang Li ◽  
Wenqian Cheng ◽  
Tao Wu ◽  
Jia Li ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Signal Amplification ◽  
Lipid Membrane ◽  
Breast Cancer Patients ◽  
Her2 Positive ◽  
Chip Surface ◽  
Spr Biosensor ◽  
Aptamer Beacon

AbstractHuman epidermal growth factor receptor 2 (HER2)-positive exosomes play an extremely important role in the diagnosis and treatment options of breast cancers. Herein, based on the reformative tyramine signal amplification (TSA) enabled by molecular aptamer beacon (MAB) conversion, a label-free surface plasmon resonance (SPR) biosensor was proposed for highly sensitive and specific detection of HER2-positive exosomes. The exosomes were captured by the HER2 aptamer region of MAB immobilized on the chip surface, which enabled the exposure of the G-quadruplex DNA (G4 DNA) that could form peroxidase-like G4-hemin. In turn, the formed G4-hemin catalyzed the deposition of plentiful tyramine-coated gold nanoparticles (AuNPs-Ty) on the exosome membrane with the help of H2O2, generating a significantly enhanced SPR signal. In the reformative TSA system, the horseradish peroxidase (HRP) as a major component was replaced with nonenzymic G4-hemin, bypassing the defects of natural enzymes. Moreover, the dual-recognition of the surface proteins and lipid membrane of the desired exosomes endowed the sensing strategy with high specificity without the interruption of free proteins. As a result, this developed SPR biosensor exhibited a wide linear range from 1.0 × 104 to 1.0 × 107 particles/mL. Importantly, this strategy was able to accurately distinguish HER2-positive breast cancer patients from healthy individuals, exhibiting great potential clinical application. Graphical Abstract

scholarly journals Kajian Pengaruh Material Graphene pada kinerja Biosensor Berbasis Surface Plasmon Resonance (SPR) pada Deteksi Makanan Halal sebagai Pendukung Halal Research Center UIN Sunan Kalijaga Yogyakarta

2017 ◽  
Vol 7 (1) ◽  
pp. 1
Author(s):  
Wida Yanti ◽  
Asih Melati
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Analytical Calculation ◽  
Detection Sensitivity ◽  
Research Center ◽  
Attenuated Total Reflectance ◽  
Muslim Community ◽  
Spr Biosensor

<p><br />Halal foods and medicines are an absolute daily needs for the Muslim community in Indonesia. Therefore the authority institutions in indonesian goverment should ensure the availability of this. It is of course inseparable from the role of higher education through the development of its technology to develop halal detection of foods and drugs. This study is an effort to contribute to the Halal Research Center of UIN Sunan Kalijaga Yogyakarta through the biosensor development in halal detection foods and medicines based on biosensor SPR. This device using graphene materials to improve the detection sensitivity of pork gelatin material that is likely contained in foodstuffs and medicine. From analytical calculation and computation, enhancement of the SPR biosensor performance by involvement graphene it was shown through the ATR (Attenuated Total Reflectance) reflective curve. The result of this results was found the enhancement of the sensitivity 2,86 %.</p><p>Keyword: Surface Plasmon Resonance (SPR), Porcine Gelatin, Graphene, ATR</p>

scholarly journals Plasmonic petal-shaped beam for microscopic phase-sensitive SPR biosensor with ultrahigh sensitivity

2013 ◽  
Vol 38 (22) ◽  
pp. 4770 ◽  
Author(s):  
Rong Wang ◽  
Luping Du ◽  
Chonglei Zhang ◽  
Zhongsheng Man ◽  
Yijia Wang ◽  
...  
Keyword(s):  
Shaped Beam ◽  
Spr Biosensor ◽  
Ultrahigh Sensitivity ◽  
Phase Sensitive
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