scholarly journals Graphene-based ultrasensitive optical microfluidic sensor for the real-time and label-free monitoring of simulated arterial blood flow

2020 ◽  
Vol 28 (11) ◽  
pp. 16594 ◽  
Author(s):  
Tiange Wu ◽  
Junfeng Shen ◽  
Zongwen Li ◽  
Tingting Zou ◽  
Wei Xin ◽  
...  
Keyword(s):  
Blood Flow ◽  
Real Time ◽  
Arterial Blood Flow ◽  
Label Free ◽  
The Real ◽  
Arterial Blood

scholarly journals Assessing arterial blood flow and vessel area variations using real-time zonal phase-contrast MRI

2006 ◽  
Vol 23 (3) ◽  
pp. 422-429 ◽  
Author(s):  
Markus Oelhafen ◽  
Juerg Schwitter ◽  
Sebastian Kozerke ◽  
Roger Luechinger ◽  
Peter Boesiger
Keyword(s):  
Blood Flow ◽  
Real Time ◽  
Phase Contrast ◽  
Arterial Blood Flow ◽  
Phase Contrast Mri ◽  
Vessel Area ◽  
Arterial Blood

scholarly journals Application of Linear Gradient Magnetic Field in Arterial Profile Scanning Imaging

Sensors ◽  
2020 ◽  
Vol 20 (16) ◽  
pp. 4547
Author(s):  
Yanjun Liu ◽  
Guoqiang Liu ◽  
Dan Yang ◽  
Bin Xu
Keyword(s):  
Magnetic Field ◽  
Finite Element ◽  
Blood Flow ◽  
Real Time ◽  
Arterial Blood Flow ◽  
Zero Magnetic Field ◽  
Gradient Magnetic Field ◽  
Linear Gradient ◽  
Arterial Blood ◽  
Scanning Imaging

Background and Objectives: Cardiovascular and cerebrovascular diseases caused by arterial stenosis and sclerosis are the main causes of human death. Although there are mature diagnostic techniques in clinical practice, they are not suitable for early disease prediction and monitoring due to their high cost and complex operation. The purpose of this paper is to study the coupling effect of arterial blood flow and linear gradient magnetic field, and to propose a method for the reconstruction of the arterial profile, which will lay a theoretical foundation for new electromagnetic artery scanning imaging technology. Methods and Models: A combination coil composed of gradient coils and drive coils is applied as a magnetic field excitation source. By controlling the excitation current, a linearly gradient magnetic field with a line-shaped zero magnetic field is generated, and the zero magnetic field is driven to scan in a specific direction. According to the magnetoelectric effect of blood flow, under the action of the external magnetic field, the voltage signals on the body surface can be detected by measuring electrodes. The location of the artery center line can be determined by the time–space relationship between voltage signals and zero magnetic field scanning. In addition, based on the reciprocity theorem integral equation, a numerical model between the amplitude of the voltage signal and the arterial radius is derived to reconstruct the arterial radius. The above physical process was simulated in the finite element analysis software COMSOL, and the voltage signals obtained from the simulation verified the arterial profile reconstruction. Results: Through finite element simulation verification, the imaging method based on a linear gradient magnetic field has a numerical accuracy of 90% and a spatial resolution of 1 mm. Moreover, under 100 Hz low-frequency alternating current excitation, the single scanning time is 0.005 s, which is far shorter than the arterial blood flow change cycle, meeting the requirements of real-time imaging. The results demonstrate the effectiveness and high theoretical feasibility of the proposed method in real-time arterial imaging. Conclusions: This study indicates the potential application of linear gradient magnetic fields in arterial profile imaging. Compared with traditional electromagnetic imaging methods, the proposed method has the advantages of fast imaging speed and high resolution, showing the certain application value in early real-time imaging of arterial disease. However, further studies are necessary to confirm its effectiveness in clinical practice by more medical data and real cases.

Doxorubicin-induced vascular toxicity: Targeting potential pathways to reduce procoagulant activity.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e13080-e13080
Author(s):  
Hadas Bar-Joseph ◽  
Irit Ben-Aharon ◽  
Moran Tzabari ◽  
Naftaly Savion ◽  
Ruth Shalgi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Real Time ◽  
Platelet Adhesion ◽  
Platelet Rich Plasma ◽  
Fold Increase ◽  
Acute Effect ◽  
Arterial Blood Flow ◽  
Vascular Toxicity ◽  
Arterial Blood

e13080 Background: In a former study in mice using the gonads as an end-organ prototype, we have characterized by real-time intravital imaging an acute deleterious effect of doxorubicin (DXR) on the gonadal vasculature, manifested by a reduction in blood flow and disintegration of the vessel wall. We hypothesized this pattern may represent the formation of microthrombi. We aimed to further characterize the effect of DXR on platelets’ function and to use potentially protectants to reduce DXR acute effect on the blood flow. Methods: 100 µg/mouse 24 hours and 1 hour prior to DXR treatment (8 mg/kg), or with eptifibatide (integrilin,75µg/mouse) 90min prior to DXR treatment. Testicular arterial blood flow was examined in real-time by pulse wave Doppler ultrasound. Platelet adhesion to confluent endothelial cells (EC) was evaluated following exposure of EC to DXR (100 µM) for 4h followed by exposure to whole blood under defined shear rates. Fixed platelets were immunostained by anti- CD41a antibody. DXR effect on platelet adhesion was determined by pre-incubation of platelet rich plasma for 15min with increasing concentrations of DXR and induction of aggregation by ADP. For in vivo study, mice were injected with either LMWH (Enoxaparin; Clexane). Results: There was a significant 3.6-fold increase in platelet adhesion to DXR-exposed EC (p<0.002) reflecting the toxic effect of DXR on EC. Yet, significant DXR- dose dependent decrease in platelet aggregation was observed reaching up to 40% inhibition at 100 µM (p<0.001). Testicular arterial blood flow was preserved as a result of pre-treatment with LMWH or eptifibatide prior to DXR (P<0.01). Conclusions: DXR-induced acute vascular toxicity may trigger the coagulation pathway while enhancing platelet adhesion yet inhibiting massive aggregation, which result in compromised blood flow due to microthrombi formation. Anti-platelet/anti-coagulant agents appear to be effective in reducing the detrimental effect of DXR on the vasculature.

scholarly journals Real Time Monitoring of Peripheral Arterial Blood Flow Velocity and Volume During Aneurysm Clipping Using Doppler Flow Meter

1994 ◽  
Vol 22 (5) ◽  
pp. 379-383
Author(s):  
Hiroshi UENOHARA ◽  
Tomoko KOBAYASHI ◽  
Akiko NISHINO ◽  
Shinsuke SUZUKI ◽  
Hiroaki ARAI ◽  
...  
Keyword(s):  
Blood Flow ◽  
Flow Velocity ◽  
Real Time ◽  
Blood Flow Velocity ◽  
Arterial Blood Flow ◽  
Flow Meter ◽  
Doppler Flow ◽  
Aneurysm Clipping ◽  
Arterial Blood ◽  
Peripheral Arterial

Modeling Elastic Walls in Lattice Boltzmann Simulations of Arterial Blood Flow

2013 ◽  
Vol 23 (2) ◽  
Author(s):  
Xenia Descovich ◽  
Giuseppe Pontrelli ◽  
Sauro Succi ◽  
Simone Melchionna ◽  
Manfred Bammer
Keyword(s):  
Blood Flow ◽  
Lattice Boltzmann ◽  
Arterial Blood Flow ◽  
Arterial Blood ◽  
Lattice Boltzmann Simulations ◽  
Elastic Walls

scholarly journals Sustained Inflation Reduces Pulmonary Blood Flow during Resuscitation with an Intact Cord

Children ◽  
2021 ◽  
Vol 8 (5) ◽  
pp. 353
Author(s):  
Jayasree Nair ◽  
Lauren Davidson ◽  
Sylvia Gugino ◽  
Carmon Koenigsknecht ◽  
Justin Helman ◽  
...  
Keyword(s):  
Blood Flow ◽  
Perinatal Asphyxia ◽  
Arterial Blood Flow ◽  
Positive Pressure ◽  
Optimal Timing ◽  
Delayed Cord Clamping ◽  
Arterial Blood ◽  
Cord Clamping ◽  
Sustained Inflation ◽  
Near Term

The optimal timing of cord clamping in asphyxia is not known. Our aims were to determine the effect of ventilation (sustained inflation–SI vs. positive pressure ventilation–V) with early (ECC) or delayed cord clamping (DCC) in asphyxiated near-term lambs. We hypothesized that SI with DCC improves gas exchange and hemodynamics in near-term lambs with asphyxial bradycardia. A total of 28 lambs were asphyxiated to a mean blood pressure of 22 mmHg. Lambs were randomized based on the timing of cord clamping (ECC—immediate, DCC—60 s) and mode of initial ventilation into five groups: ECC + V, ECC + SI, DCC, DCC + V and DCC + SI. The magnitude of placental transfusion was assessed using biotinylated RBC. Though an asphyxial bradycardia model, 2–3 lambs in each group were arrested. There was no difference in primary outcomes, the time to reach baseline carotid blood flow (CBF), HR ≥ 100 bpm or MBP ≥ 40 mmHg. SI reduced pulmonary (PBF) and umbilical venous (UV) blood flow without affecting CBF or umbilical arterial blood flow. A significant reduction in PBF with SI persisted for a few minutes after birth. In our model of perinatal asphyxia, an initial SI breath increased airway pressure, and reduced PBF and UV return with an intact cord. Further clinical studies evaluating the timing of cord clamping and ventilation strategy in asphyxiated infants are warranted.

Incidence and risk factors of early arterial blood flow stasis during first radioembolization of primary and secondary liver malignancy using resin microspheres: an initial single-center analysis

2015 ◽  
Vol 26 (8) ◽  
pp. 2779-2789 ◽  
Author(s):  
Claus Christian Pieper ◽  
Winfried A. Willinek ◽  
Daniel Thomas ◽  
Hojjat Ahmadzadehfar ◽  
Markus Essler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Flow ◽  
Arterial Blood Flow ◽  
Single Center ◽  
Liver Malignancy ◽  
Arterial Blood ◽  
Resin Microspheres ◽  
Flow Stasis
Sign in / Sign up

Export Citation Format

Share Document