scholarly journals Assessing arterial blood flow and vessel area variations using real-time zonal phase-contrast MRI

2006 ◽  
Vol 23 (3) ◽  
pp. 422-429 ◽  
Author(s):  
Markus Oelhafen ◽  
Juerg Schwitter ◽  
Sebastian Kozerke ◽  
Roger Luechinger ◽  
Peter Boesiger
Keyword(s):  
Blood Flow ◽  
Real Time ◽  
Phase Contrast ◽  
Arterial Blood Flow ◽  
Phase Contrast Mri ◽  
Vessel Area ◽  
Arterial Blood

scholarly journals Effects of short-term exposure to head-down tilt on cerebral hemodynamics: a prospective evaluation of a spaceflight analog using phase-contrast MRI

2016 ◽  
Vol 120 (12) ◽  
pp. 1466-1473 ◽  
Author(s):  
Karina Marshall-Goebel ◽  
Khalid Ambarki ◽  
Anders Eklund ◽  
Jan Malm ◽  
Edwin Mulder ◽  
...  
Keyword(s):  
Blood Flow ◽  
Phase Contrast ◽  
Cerebral Hemodynamics ◽  
Arterial Blood Flow ◽  
Ambient Atmosphere ◽  
Phase Contrast Mri ◽  
Jugular Veins ◽  
Cross Sectional ◽  
Arterial Blood ◽  
Short Term Exposure

Alterations in cerebral hemodynamics in microgravity are hypothesized to occur during spaceflight and could be linked to the Visual Impairment and Intracranial Pressure syndrome. Head-down tilt (HDT) is frequently used as a ground-based analog to simulate cephalad fluid shifts in microgravity; however, its effects on cerebral hemodynamics have not been well studied with MRI techniques. Here, we evaluate the effects of 1) various HDT angles on cerebral arterial and venous hemodynamics; and 2) exposure to 1% CO2 during an intermediate HDT angle (−12°) as an additional space-related environmental factor. Blood flow, cross-sectional area (CSA), and blood flow velocity were measured with phase-contrast MRI in the internal jugular veins, as well as the vertebral and internal carotid arteries. Nine healthy male subjects were measured at baseline (supine, 0°) and after 4.5 h of HDT at −6°, −12° (with and without 1% CO2), and −18°. We found a decrease in total arterial blood flow from baseline during all angles of HDT. On the venous side, CSA increased with HDT, and outflow decreased during −12° HDT ( P = 0.039). Moreover, the addition of 1% CO2 to −12° HDT caused an increase in total arterial blood flow ( P = 0.016) and jugular venous outflow ( P < 0.001) compared with −12° HDT with ambient atmosphere. Overall, the results indicate decreased cerebral blood flow during HDT, which may have implications for microgravity-induced cerebral hemodynamic changes.

Caval Subtraction 2D Phase-Contrast MRI to Measure Total Liver and Hepatic Arterial Blood Flow

2017 ◽  
Vol 52 (3) ◽  
pp. 170-176 ◽  
Author(s):  
Manil D. Chouhan ◽  
Rajeshwar P. Mookerjee ◽  
Alan Bainbridge ◽  
Shonit Punwani ◽  
Helen Jones ◽  
...  
Keyword(s):  
Blood Flow ◽  
Phase Contrast ◽  
Arterial Blood Flow ◽  
Phase Contrast Mri ◽  
Hepatic Arterial Blood Flow ◽  
Total Liver ◽  
Arterial Blood

scholarly journals Real-time phase-contrast MRI of cardiovascular blood flow using undersampled radial fast low-angle shot and nonlinear inverse reconstruction

2011 ◽  
Vol 25 (7) ◽  
pp. 917-924 ◽  
Author(s):  
Arun A. Joseph ◽  
Klaus-Dietmar Merboldt ◽  
Dirk Voit ◽  
Shuo Zhang ◽  
Martin Uecker ◽  
...  
Keyword(s):  
Blood Flow ◽  
Real Time ◽  
Phase Contrast ◽  
Phase Contrast Mri ◽  
Inverse Reconstruction ◽  
Cardiovascular Blood Flow

scholarly journals Graphene-based ultrasensitive optical microfluidic sensor for the real-time and label-free monitoring of simulated arterial blood flow

2020 ◽  
Vol 28 (11) ◽  
pp. 16594 ◽  
Author(s):  
Tiange Wu ◽  
Junfeng Shen ◽  
Zongwen Li ◽  
Tingting Zou ◽  
Wei Xin ◽  
...  
Keyword(s):  
Blood Flow ◽  
Real Time ◽  
Arterial Blood Flow ◽  
Label Free ◽  
The Real ◽  
Arterial Blood

scholarly journals Use of Caval Subtraction 2D Phase-Contrast MR Imaging to Measure Total Liver and Hepatic Arterial Blood Flow: Preclinical Validation and Initial Clinical Translation

Radiology ◽  
2016 ◽  
Vol 280 (3) ◽  
pp. 916-923 ◽  
Author(s):  
Manil D. Chouhan ◽  
Rajeshwar P. Mookerjee ◽  
Alan Bainbridge ◽  
Simon Walker-Samuel ◽  
Nathan Davies ◽  
...  
Keyword(s):  
Blood Flow ◽  
Mr Imaging ◽  
Phase Contrast ◽  
Clinical Translation ◽  
Arterial Blood Flow ◽  
Hepatic Arterial Blood Flow ◽  
Total Liver ◽  
Arterial Blood

How is pulmonary arterial blood flow affected by pulmonary venous obstruction in children? A phase-contrast magnetic resonance study

2005 ◽  
Vol 35 (6) ◽  
pp. 580-586 ◽  
Author(s):  
Kevin S. Roman ◽  
Christian J. Kellenberger ◽  
Christopher K. Macgowan ◽  
John Coles ◽  
Andrew N. Redington ◽  
...  
Keyword(s):  
Blood Flow ◽  
Magnetic Resonance ◽  
Phase Contrast ◽  
Arterial Blood Flow ◽  
Pulmonary Venous Obstruction ◽  
Venous Obstruction ◽  
Magnetic Resonance Study ◽  
Arterial Blood ◽  
Contrast Magnetic Resonance ◽  
Pulmonary Arterial

scholarly journals Application of Linear Gradient Magnetic Field in Arterial Profile Scanning Imaging

Sensors ◽  
2020 ◽  
Vol 20 (16) ◽  
pp. 4547
Author(s):  
Yanjun Liu ◽  
Guoqiang Liu ◽  
Dan Yang ◽  
Bin Xu
Keyword(s):  
Magnetic Field ◽  
Finite Element ◽  
Blood Flow ◽  
Real Time ◽  
Arterial Blood Flow ◽  
Zero Magnetic Field ◽  
Gradient Magnetic Field ◽  
Linear Gradient ◽  
Arterial Blood ◽  
Scanning Imaging

Background and Objectives: Cardiovascular and cerebrovascular diseases caused by arterial stenosis and sclerosis are the main causes of human death. Although there are mature diagnostic techniques in clinical practice, they are not suitable for early disease prediction and monitoring due to their high cost and complex operation. The purpose of this paper is to study the coupling effect of arterial blood flow and linear gradient magnetic field, and to propose a method for the reconstruction of the arterial profile, which will lay a theoretical foundation for new electromagnetic artery scanning imaging technology. Methods and Models: A combination coil composed of gradient coils and drive coils is applied as a magnetic field excitation source. By controlling the excitation current, a linearly gradient magnetic field with a line-shaped zero magnetic field is generated, and the zero magnetic field is driven to scan in a specific direction. According to the magnetoelectric effect of blood flow, under the action of the external magnetic field, the voltage signals on the body surface can be detected by measuring electrodes. The location of the artery center line can be determined by the time–space relationship between voltage signals and zero magnetic field scanning. In addition, based on the reciprocity theorem integral equation, a numerical model between the amplitude of the voltage signal and the arterial radius is derived to reconstruct the arterial radius. The above physical process was simulated in the finite element analysis software COMSOL, and the voltage signals obtained from the simulation verified the arterial profile reconstruction. Results: Through finite element simulation verification, the imaging method based on a linear gradient magnetic field has a numerical accuracy of 90% and a spatial resolution of 1 mm. Moreover, under 100 Hz low-frequency alternating current excitation, the single scanning time is 0.005 s, which is far shorter than the arterial blood flow change cycle, meeting the requirements of real-time imaging. The results demonstrate the effectiveness and high theoretical feasibility of the proposed method in real-time arterial imaging. Conclusions: This study indicates the potential application of linear gradient magnetic fields in arterial profile imaging. Compared with traditional electromagnetic imaging methods, the proposed method has the advantages of fast imaging speed and high resolution, showing the certain application value in early real-time imaging of arterial disease. However, further studies are necessary to confirm its effectiveness in clinical practice by more medical data and real cases.

Doxorubicin-induced vascular toxicity: Targeting potential pathways to reduce procoagulant activity.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e13080-e13080
Author(s):  
Hadas Bar-Joseph ◽  
Irit Ben-Aharon ◽  
Moran Tzabari ◽  
Naftaly Savion ◽  
Ruth Shalgi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Real Time ◽  
Platelet Adhesion ◽  
Platelet Rich Plasma ◽  
Fold Increase ◽  
Acute Effect ◽  
Arterial Blood Flow ◽  
Vascular Toxicity ◽  
Arterial Blood

e13080 Background: In a former study in mice using the gonads as an end-organ prototype, we have characterized by real-time intravital imaging an acute deleterious effect of doxorubicin (DXR) on the gonadal vasculature, manifested by a reduction in blood flow and disintegration of the vessel wall. We hypothesized this pattern may represent the formation of microthrombi. We aimed to further characterize the effect of DXR on platelets’ function and to use potentially protectants to reduce DXR acute effect on the blood flow. Methods: 100 µg/mouse 24 hours and 1 hour prior to DXR treatment (8 mg/kg), or with eptifibatide (integrilin,75µg/mouse) 90min prior to DXR treatment. Testicular arterial blood flow was examined in real-time by pulse wave Doppler ultrasound. Platelet adhesion to confluent endothelial cells (EC) was evaluated following exposure of EC to DXR (100 µM) for 4h followed by exposure to whole blood under defined shear rates. Fixed platelets were immunostained by anti- CD41a antibody. DXR effect on platelet adhesion was determined by pre-incubation of platelet rich plasma for 15min with increasing concentrations of DXR and induction of aggregation by ADP. For in vivo study, mice were injected with either LMWH (Enoxaparin; Clexane). Results: There was a significant 3.6-fold increase in platelet adhesion to DXR-exposed EC (p<0.002) reflecting the toxic effect of DXR on EC. Yet, significant DXR- dose dependent decrease in platelet aggregation was observed reaching up to 40% inhibition at 100 µM (p<0.001). Testicular arterial blood flow was preserved as a result of pre-treatment with LMWH or eptifibatide prior to DXR (P<0.01). Conclusions: DXR-induced acute vascular toxicity may trigger the coagulation pathway while enhancing platelet adhesion yet inhibiting massive aggregation, which result in compromised blood flow due to microthrombi formation. Anti-platelet/anti-coagulant agents appear to be effective in reducing the detrimental effect of DXR on the vasculature.

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