In Vivo Assessment of Molecular Aging by Quasi-Elastic Light Scattering in the Human Lens

2016 ◽  
Author(s):  
O. Minaeva ◽  
S. Sarangi ◽  
J.A. Moncaster ◽  
D.M. Ledoux ◽  
C.A. Rook ◽  
...  
Keyword(s):  
Light Scattering ◽  
Human Lens ◽  
Elastic Light Scattering ◽  
Molecular Aging ◽  
In Vivo Assessment

P4-066: In Vivo Assessment of Molecular Aging by Quasi-Elastic Light Scattering in Human Lens

2016 ◽  
Vol 12 ◽  
pp. P1039-P1039
Author(s):  
Juliet A. Moncaster ◽  
Olga Minaeva ◽  
Srikant Sarangi ◽  
Danielle Ledoux ◽  
Caitlin Rook ◽  
...  
Keyword(s):  
Light Scattering ◽  
Human Lens ◽  
Elastic Light Scattering ◽  
Molecular Aging ◽  
In Vivo Assessment

scholarly journals In Vivo Quasi-Elastic Light Scattering Eye Scanner Detects Molecular Aging in Humans

2020 ◽  
Vol 75 (9) ◽  
pp. e53-e62
Author(s):  
Olga Minaeva ◽  
Srikant Sarangi ◽  
Danielle M Ledoux ◽  
Juliet A Moncaster ◽  
Douglas S Parsons ◽  
...  
Keyword(s):  
Light Scattering ◽  
Human Lens ◽  
Fetal Life ◽  
Healthy Human ◽  
Elastic Light Scattering ◽  
Lens Proteins ◽  
Age Dependent ◽  
Molecular Aging

Abstract The absence of clinical tools to evaluate individual variation in the pace of aging represents a major impediment to understanding aging and maximizing health throughout life. The human lens is an ideal tissue for quantitative assessment of molecular aging in vivo. Long-lived proteins in lens fiber cells are expressed during fetal life, do not undergo turnover, accumulate molecular alterations throughout life, and are optically accessible in vivo. We used quasi-elastic light scattering (QLS) to measure age-dependent signals in lenses of healthy human subjects. Age-dependent QLS signal changes detected in vivo recapitulated time-dependent changes in hydrodynamic radius, protein polydispersity, and supramolecular order of human lens proteins during long-term incubation (~1 year) and in response to sustained oxidation (~2.5 months) in vitro. Our findings demonstrate that QLS analysis of human lens proteins provides a practical technique for noninvasive assessment of molecular aging in vivo.

scholarly journals In Vivo Quasi-Elastic Light Scattering Eye Scanner Detects Molecular Aging in Humans and Mice

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 950-950
Author(s):  
Douglas Parsons ◽  
Olga Minaeva ◽  
Srikant Sarangi ◽  
Danielle Ledoux ◽  
Juliet Moncaster ◽  
...  
Keyword(s):  
Light Scattering ◽  
Human Lens ◽  
Fetal Life ◽  
Healthy Human ◽  
Elastic Light Scattering ◽  
Lens Proteins ◽  
Age Dependent ◽  
Molecular Aging

Abstract The absence of clinical tools to evaluate individual variation in the pace of aging represents a major impediment to understanding aging and maximizing health throughout life. The lens is an ideal tissue for quantitative assessment of molecular aging in vivo. Long-lived proteins in lens fiber cells are expressed during fetal life, do not undergo turnover, accumulate molecular alterations throughout life, and are optically accessible in vivo. We used quasi-elastic light scattering (QLS) to measure age-dependent signals in lenses of both healthy human subjects and wild-type C57BL/6 mice. Age-dependent QLS signal changes detected in vivo in humans and mice recapitulated time-dependent changes in hydrodynamic radius, protein polydispersity, and supramolecular order of human lens proteins during long-term incubation (~1 year) and in response to sustained oxidation (~2.5 months) in vitro. Our findings demonstrate that QLS analysis of lens proteins provides a practical technique for noninvasive assessment of molecular aging in vivo.

In Vivo Measurements On Human Lens Using Quasielastic Light Scattering

1987 ◽  
Author(s):  
Peter C. Magnante ◽  
Leo T. Chylack ◽  
George B. Benedek ◽  
Teodosio Libondi ◽  
Stephen N. Joffe ◽  
...  
Keyword(s):  
Light Scattering ◽  
Human Lens ◽  
Quasielastic Light Scattering ◽  
In Vivo Measurements

Monitoring Molecular Aging of Lens Proteins using Noninvasive Quasi-Elastic Light Scattering

2015 ◽  
Author(s):  
S. Sarangi ◽  
O. Minaeva ◽  
J. A. Moncaster ◽  
F. Weng ◽  
C. Rook ◽  
...  
Keyword(s):  
Light Scattering ◽  
Elastic Light Scattering ◽  
Lens Proteins ◽  
Molecular Aging

IC-P-127: Non-invasive early detection of beta-amyloid molecular pathology by quasi-elastic light scattering in vivo

2006 ◽  
Vol 2 ◽  
pp. S703-S703
Author(s):  
Lee E. Goldstein ◽  
Robert Moir ◽  
Suqian Lu ◽  
Ling Fu ◽  
Oliver Chadwick ◽  
...  
Keyword(s):  
Light Scattering ◽  
Early Detection ◽  
Molecular Pathology ◽  
Beta Amyloid ◽  
Elastic Light Scattering ◽  
Non Invasive

scholarly journals P1-128: Non-invasive early detection of beta-amyloid molecular pathology by quasi-elastic light scattering in vivo

2006 ◽  
Vol 2 ◽  
pp. S133-S133 ◽  
Author(s):  
Lee E. Goldstein ◽  
Robert Moir ◽  
Suqian Lu ◽  
Ling Fu ◽  
Oliver Chadwick ◽  
...  
Keyword(s):  
Light Scattering ◽  
Early Detection ◽  
Molecular Pathology ◽  
Beta Amyloid ◽  
Elastic Light Scattering ◽  
Non Invasive

Quasi-Elastic Light Scattering And Other Objective Measures Of Cataractous Change In Vivo

1987 ◽  
Author(s):  
Leo T. Chylack,Jr. ◽  
David Magnante ◽  
Stephen N. Joffe ◽  
John A. Parrish
Keyword(s):  
Light Scattering ◽  
Objective Measures ◽  
Elastic Light Scattering
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