In Vivo Measurements On Human Lens Using Quasielastic Light Scattering

1987 ◽  
Author(s):  
Peter C. Magnante ◽  
Leo T. Chylack ◽  
George B. Benedek ◽  
Teodosio Libondi ◽  
Stephen N. Joffe ◽  
...  
Keyword(s):  
Light Scattering ◽  
Human Lens ◽  
Quasielastic Light Scattering ◽  
In Vivo Measurements

scholarly journals In Vivo Quasi-Elastic Light Scattering Eye Scanner Detects Molecular Aging in Humans

2020 ◽  
Vol 75 (9) ◽  
pp. e53-e62
Author(s):  
Olga Minaeva ◽  
Srikant Sarangi ◽  
Danielle M Ledoux ◽  
Juliet A Moncaster ◽  
Douglas S Parsons ◽  
...  
Keyword(s):  
Light Scattering ◽  
Human Lens ◽  
Fetal Life ◽  
Healthy Human ◽  
Elastic Light Scattering ◽  
Lens Proteins ◽  
Age Dependent ◽  
Molecular Aging

Abstract The absence of clinical tools to evaluate individual variation in the pace of aging represents a major impediment to understanding aging and maximizing health throughout life. The human lens is an ideal tissue for quantitative assessment of molecular aging in vivo. Long-lived proteins in lens fiber cells are expressed during fetal life, do not undergo turnover, accumulate molecular alterations throughout life, and are optically accessible in vivo. We used quasi-elastic light scattering (QLS) to measure age-dependent signals in lenses of healthy human subjects. Age-dependent QLS signal changes detected in vivo recapitulated time-dependent changes in hydrodynamic radius, protein polydispersity, and supramolecular order of human lens proteins during long-term incubation (~1 year) and in response to sustained oxidation (~2.5 months) in vitro. Our findings demonstrate that QLS analysis of human lens proteins provides a practical technique for noninvasive assessment of molecular aging in vivo.

Protein size resolution in human eye lenses by dynamic light scattering after in vivo measurements

1998 ◽  
Vol 236 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Karsten Dierks ◽  
Matthias Dieckmann ◽  
Dirk Niederstrasser ◽  
Robert Schwartz ◽  
Alfred Wegener
Keyword(s):  
Light Scattering ◽  
Dynamic Light Scattering ◽  
Human Eye ◽  
In Vivo Measurements ◽  
Protein Size

Quasielastic light scattering study of the living human lens as a function of age

1997 ◽  
Vol 16 (3) ◽  
pp. 197-207 ◽  
Author(s):  
George M. Thurston ◽  
Douglas L. Hayden ◽  
Pendra Burrows ◽  
John I. Clark ◽  
Victor G. Taret ◽  
...  
Keyword(s):  
Light Scattering ◽  
Human Lens ◽  
Quasielastic Light Scattering ◽  
Scattering Study

In Vivo Assessment of Molecular Aging by Quasi-Elastic Light Scattering in the Human Lens

2016 ◽  
Author(s):  
O. Minaeva ◽  
S. Sarangi ◽  
J.A. Moncaster ◽  
D.M. Ledoux ◽  
C.A. Rook ◽  
...  
Keyword(s):  
Light Scattering ◽  
Human Lens ◽  
Elastic Light Scattering ◽  
Molecular Aging ◽  
In Vivo Assessment

P4-066: In Vivo Assessment of Molecular Aging by Quasi-Elastic Light Scattering in Human Lens

2016 ◽  
Vol 12 ◽  
pp. P1039-P1039
Author(s):  
Juliet A. Moncaster ◽  
Olga Minaeva ◽  
Srikant Sarangi ◽  
Danielle Ledoux ◽  
Caitlin Rook ◽  
...  
Keyword(s):  
Light Scattering ◽  
Human Lens ◽  
Elastic Light Scattering ◽  
Molecular Aging ◽  
In Vivo Assessment
Sign in / Sign up

Export Citation Format

Share Document