Concurrent Optical Coherence Tomography and Line-Scanning Laminar Optical Tomography

2009 ◽  
Author(s):  
Shuai Yuan ◽  
Qian Li ◽  
James Jiang ◽  
Alex Cable ◽  
Yu Chen
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Tomography ◽  
Optical Coherence ◽  
Line Scanning

Design of a linear K-Space Spectrometer with GRISM for Line Scanning Optical Coherence Tomography

2021 ◽  
Author(s):  
Sevin Samadi ◽  
Sivakumar Narayanswamy ◽  
Javad Dargahi ◽  
Masoud Mohazzab
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Line Scanning

scholarly journals Design and Optimization of a Linear Wavenumber Spectrometer with Cylindrical Optics for Line Scanning Optical Coherence Tomography

Sensors ◽  
2021 ◽  
Vol 21 (19) ◽  
pp. 6463
Author(s):  
Sevin Samadi ◽  
Javad Dargahi ◽  
Sivakumar Narayanswamy
Keyword(s):  
Optical Coherence Tomography ◽  
Image Quality ◽  
High Speed ◽  
High Efficiency ◽  
Optical Design ◽  
Optical Coherence ◽  
High Speed Imaging ◽  
Nonlinearity Error ◽  
Line Scanning

We report the design of a high-efficiency spectral-domain spectrometer with cylindrical optics for line scanning optical coherence tomography (OCT). The spectral nonlinearity in k space (wavenumber) lowers the depth-dependent signal sensitivity of the spectrometers. For linearizing, in this design, grating and prism have been introduced. For line scanning, a cylindrical mirror is utilized in the scanning part. Line scanning improves the speed of imaging compared to fly-spot scanning. Line scanning OCT requires a spectrometer that utilizes cylindrical optics. In this work, an optical design of a linear wavenumber spectrometer with cylindrical optics is introduced. While there are many works using grating and prism to linearize the K space spectrometer design, there is no work on linearizing the k-space spectrometer with cylindrical optics for line scanning that provides high sensitivity and high-speed imaging without the need for resampling. The design of the spectrometer was achieved through MATLAB and ZEMAX simulations. The spectrometer design is optimized for the broadband light source with a center wavelength of 830 ± 100 nm (8.607 μm−1− 6.756 μm−1 in k-space). The variation in the output angle with respect to the wavenumber can be mentioned as a nonlinearity error. From our design results, it is observed that the nonlinearity error reduced from 147.0115 to 0.0149 Δθ*μm within the wavenumber range considered. The use of the proposed reflective optics for focusing reduces the chromatic aberration and increases image quality (measured by the Strehl ratio (SR)). The complete system will provide clinicians a powerful tool for real-time diagnosis, treatment, and guidance in surgery with high image quality for in-vivo applications.

Optical Biopsy of Lymph Node Morphology using Optical Coherence Tomography

2005 ◽  
Vol 4 (5) ◽  
pp. 539-547 ◽  
Author(s):  
Wei Luo ◽  
Freddy T. Nguyen ◽  
Adam M. Zysk ◽  
Tyler S. Ralston ◽  
John Brockenbrough ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Lymph Node ◽  
High Resolution ◽  
Breast Imaging ◽  
Optical Tomography ◽  
Screening Method ◽  
Optical Biopsy ◽  
Infrared Light ◽  
Optical Coherence ◽  
Cross Sectional

Optical diagnostic imaging techniques are increasingly being used in the clinical environment, allowing for improved screening and diagnosis while minimizing the number of invasive procedures. Diffuse optical tomography, for example, is capable of whole-breast imaging and is being developed as an alternative to traditional X-ray mammography. While this may eventually be a very effective screening method, other optical techniques are better suited for imaging on the cellular and molecular scale. Optical Coherence Tomography (OCT), for instance, is capable of high-resolution cross-sectional imaging of tissue morphology. In a manner analogous to ultrasound imaging except using optics, pulses of near-infrared light are sent into the tissue while coherence-gated reflections are measured interferometrically to form a cross-sectional image of tissue. In this paper we apply OCT techniques for the high-resolution three-dimensional visualization of lymph node morphology. We present the first reported OCT images showing detailed morphological structure and corresponding histological features of lymph nodes from a carcinogen-induced rat mammary tumor model, as well as from a human lymph node containing late stage metastatic disease. The results illustrate the potential for OCT to visualize detailed lymph node structures on the scale of micrometastases and the potential for the detection of metastatic nodal disease intraoperatively.

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