High density speckle contrast optical tomography for transcranial, three-dimensional imaging of cerebral blood flow in rodents

2016 ◽  
Author(s):  
Joseph L. Hollmann ◽  
Tanja Dragojević ◽  
Hari M. Varma ◽  
Carles Justicia ◽  
Claudia P. Valdes ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Optical Tomography ◽  
Three Dimensional ◽  
High Density ◽  
Three Dimensional Imaging ◽  
Speckle Contrast

scholarly journals High-density speckle contrast optical tomography of cerebral blood flow response to functional stimuli in the rodent brain

2019 ◽  
Vol 6 (04) ◽  
pp. 1 ◽  
Author(s):  
Tanja Dragojević ◽  
Ernesto E. Vidal Rosas ◽  
Joseph L. Hollmann ◽  
Joseph P. Culver ◽  
Carles Justicia ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Optical Tomography ◽  
High Density ◽  
Speckle Contrast ◽  
Blood Flow Response ◽  
Flow Response ◽  
Rodent Brain

scholarly journals High-density speckle contrast optical tomography (SCOT) for three dimensional tomographic imaging of the small animal brain

NeuroImage ◽  
2017 ◽  
Vol 153 ◽  
pp. 283-292 ◽  
Author(s):  
Tanja Dragojević ◽  
Hari M. Varma ◽  
Joseph L. Hollmann ◽  
Claudia P. Valdes ◽  
Joseph P. Culver ◽  
...  
Keyword(s):  
Optical Tomography ◽  
Three Dimensional ◽  
Small Animal ◽  
Tomographic Imaging ◽  
High Density ◽  
Speckle Contrast ◽  
Animal Brain

scholarly journals Speckle contrast optical tomography: A new method for deep tissue three-dimensional tomography of blood flow

2014 ◽  
Vol 5 (4) ◽  
pp. 1275 ◽  
Author(s):  
Hari M. Varma ◽  
Claudia P. Valdes ◽  
Anna K. Kristoffersen ◽  
Joseph P. Culver ◽  
Turgut Durduran
Keyword(s):  
Blood Flow ◽  
Optical Tomography ◽  
Three Dimensional ◽  
New Method ◽  
Deep Tissue ◽  
Speckle Contrast

Serial measurement of regional cerebral blood flow in patients with SAH using 133Xe inhalation and emission computerized tomography

1984 ◽  
Vol 60 (5) ◽  
pp. 916-922 ◽  
Author(s):  
Bruce Mickey ◽  
Sissel Vorstrup ◽  
Bo Voldby ◽  
Helle Lindewald ◽  
Aage Harmsen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Computerized Tomography ◽  
Cerebral Arteries ◽  
Three Dimensional ◽  
Neurological Deficits ◽  
Content Type ◽  
Serial Measurement ◽  
Regional Flow ◽  
Delayed Neurological Deterioration

✓ A noninvasive three-dimensional method for measuring cerebral blood flow (CBF), xenon-133 inhalation and emission computerized tomography, was used to investigate the CBF changes accompanying delayed neurological deterioration following subarachnoid hemorrhage (SAH). A total of 67 measurements were performed on 20 patients in Hunt and Hess' clinical Grades I to III in the first 21 days post SAH. Five patients with normal CBF tomograms on admission developed delayed neurological deficits in the 2nd week after hemorrhage, at which time repeat CBF tomograms in four patients revealed large areas of well defined regional flow decrease in the vascular territories of the anterior or middle cerebral arteries. Severe vasospasm was noted in three of these patients in whom arteriography was performed in the 2nd week post SAH. Diffuse bihemispheric CBF decreases were noted later in the course of delayed neurological deficits; however, measurements obtained soon after the onset of focal symptoms suggest that the only CBF decreases directly produced by vasospasm in Grade III patients are regional changes.

scholarly journals Cerebral Blood Flow Heterogeneity in Preterm Sheep: Lack of Physiologic Support for Vascular Boundary Zones in Fetal Cerebral White Matter

2007 ◽  
Vol 28 (5) ◽  
pp. 995-1008 ◽  
Author(s):  
Melissa M McClure ◽  
Art Riddle ◽  
Mario Manese ◽  
Ning Ling Luo ◽  
Dawn A Rorvik ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Ischemia Reperfusion ◽  
Three Dimensional ◽  
Cerebral White Matter ◽  
Periventricular White Matter ◽  
Fetal Sheep ◽  
Border Zones ◽  
Neurologic Disability

Periventricular white matter (PVWM) injury is the leading cause of neurologic disability in survivors of prematurity. To address the role of ischemia in PVWM and cerebral cortical injury, we hypothesized that immaturity of spatially distal vascular ‘end zones’ or ‘border zones’ predisposes PVWM to greater decreases in cerebral blood flow (CBF) than more proximal structures. We quantified regional CBF with fluorescently labeled microspheres in 0.65 gestation fetal sheep in histopathologically defined three-dimensional regions by post hoc digital dissection and coregistration algorithms. Basal flow in PVWM was significantly lower than in gyral white matter and cortex, but was equivalent in superficial, middle, and deep PVWM. Absolute and relative CBF (expressed as percentage of basal) did not differ significantly during ischemia or reperfusion between PVWM, gyral white matter, or cortex. Moreover, CBF during ischemia-reperfusion was equivalent in three adjacent PVWM levels and was not consistent with the magnitude of severity of PVWM injury, defined by TUNEL (terminal deoxynucleotidyltransferase-mediated dUPT nick end labeling) staining. However, the magnitude of ischemia was predicted by the severity of discrete cortical lesions. Hence, unlike cerebral cortex, unique CBF disturbances did not account for the distribution of PVWM injury. Previously defined cellular maturational factors, thus, appear to have a greater influence on PVWM vulnerability to ischemic injury than the presence of immature vascular boundary zones.

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