Reflection-mode Subwavelength-resolution Photoacoustic Microscopy for Label-free Microvascular Imaging In vivo

2015 ◽  
Author(s):  
Wei Song ◽  
Wei Zheng ◽  
Qiang Xu ◽  
Riqiang Lin ◽  
Xiaojing Gong ◽  
...  
Keyword(s):  
Photoacoustic Microscopy ◽  
Label Free ◽  
Reflection Mode ◽  
Subwavelength Resolution ◽  
Microvascular Imaging

scholarly journals Subwavelength-resolution label-free photoacoustic microscopy of optical absorption in vivo

2010 ◽  
Vol 35 (19) ◽  
pp. 3195 ◽  
Author(s):  
Chi Zhang ◽  
Konstantin Maslov ◽  
Lihong V. Wang
Keyword(s):  
Optical Absorption ◽  
Photoacoustic Microscopy ◽  
Label Free ◽  
Subwavelength Resolution

scholarly journals Recovery of photoacoustic images based on accurate ultrasound positioning

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Yinhao Pan ◽  
Ningbo Chen ◽  
Liangjian Liu ◽  
Chengbo Liu ◽  
Zhiqiang Xu ◽  
...  
Keyword(s):  
Biological Tissue ◽  
Large Field ◽  
Photoacoustic Microscopy ◽  
Label Free ◽  
Imaging Data ◽  
Motor Speed ◽  
Image Correction ◽  
Microscopy Imaging ◽  
Scanning Method

AbstractPhotoacoustic microscopy is an in vivo imaging technology based on the photoacoustic effect. It is widely used in various biomedical studies because it can provide high-resolution images while being label-free, safe, and harmless to biological tissue. Polygon-scanning is an effective scanning method in photoacoustic microscopy that can realize fast imaging of biological tissue with a large field of view. However, in polygon-scanning, fluctuations of the rotating motor speed and the geometric error of the rotating mirror cause image distortions, which seriously affect the photoacoustic-microscopy imaging quality. To improve the image quality of photoacoustic microscopy using polygon-scanning, an image correction method is proposed based on accurate ultrasound positioning. In this method, the photoacoustic and ultrasound imaging data of the sample are simultaneously obtained, and the angle information of each mirror used in the polygon-scanning is extracted from the ultrasonic data to correct the photoacoustic images. Experimental results show that the proposed method can significantly reduce image distortions in photoacoustic microscopy, with the image dislocation offset decreasing from 24.774 to 10.365 μm.

scholarly journals Reflection-mode in vivo photoacoustic microscopy with subwavelength lateral resolution

2014 ◽  
Vol 5 (12) ◽  
pp. 4235 ◽  
Author(s):  
Wei Song ◽  
Wei Zheng ◽  
Ruimin Liu ◽  
Riqiang Lin ◽  
Hongtao Huang ◽  
...  
Keyword(s):  
Lateral Resolution ◽  
Photoacoustic Microscopy ◽  
Reflection Mode

scholarly journals Dual-Polarized Fiber Laser Sensor for Photoacoustic Microscopy

Sensors ◽  
2019 ◽  
Vol 19 (21) ◽  
pp. 4632 ◽  
Author(s):  
Lin ◽  
Liang ◽  
Jin ◽  
Wang
Keyword(s):  
Fiber Laser ◽  
Optical Resolution ◽  
High Sensitivity ◽  
Low Noise ◽  
Laser Sensor ◽  
Photoacoustic Microscopy ◽  
Label Free ◽  
Laser Sensors ◽  
Dual Polarized

Optical resolution photoacoustic microscopy (OR-PAM) provides high-resolution, label-free and non-invasive functional imaging for broad biomedical applications. Dual-polarized fiber laser sensors have high sensitivity, low noise, a miniature size, and excellent stability; thus, they have been used in acoustic detection in OR-PAM. Here, we review recent progress in fiber-laser-based ultrasound sensors for photoacoustic microscopy, especially the dual-polarized fiber laser sensor with high sensitivity. The principle, characterization and sensitivity optimization of this type of sensor are presented. In vivo experiments demonstrate its excellent performance in the detection of photoacoustic (PA) signals in OR-PAM. This review summarizes representative applications of fiber laser sensors in OR-PAM and discusses their further improvements.

scholarly journals Label-free photoacoustic microscopy for in-vivo tendon imaging using a fiber-based pulse laser

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Hwi Don Lee ◽  
Jun Geun Shin ◽  
Hoon Hyun ◽  
Bong-Ahn Yu ◽  
Tae Joong Eom
Keyword(s):  
Pulse Laser ◽  
Photoacoustic Microscopy ◽  
Label Free

scholarly journals Multi-parametric quantitative microvascular imaging with optical-resolution photoacoustic microscopy in vivo

2014 ◽  
Vol 22 (2) ◽  
pp. 1500 ◽  
Author(s):  
Zhenyuan Yang ◽  
Jianhua Chen ◽  
Junjie Yao ◽  
Riqiang Lin ◽  
Jing Meng ◽  
...  
Keyword(s):  
Optical Resolution ◽  
Photoacoustic Microscopy ◽  
Microvascular Imaging

In Vivo Reflection-Mode Photoacoustic Microscopy Enhanced by Plasmonic Sensing with an Acoustic Cavity

ACS Sensors ◽  
2019 ◽  
Vol 4 (10) ◽  
pp. 2697-2705 ◽  
Author(s):  
Wei Song ◽  
Guangdi Guo ◽  
Jing Wang ◽  
Yan Zhu ◽  
Chonglei Zhang ◽  
...  
Keyword(s):  
Photoacoustic Microscopy ◽  
Reflection Mode ◽  
Acoustic Cavity ◽  
Plasmonic Sensing

Reflection-mode submicron-resolution photoacoustic microscopy in vivo

2012 ◽  
Author(s):  
Chi Zhang ◽  
Konstantin Maslov ◽  
Song Hu ◽  
Ruimin Chen ◽  
Qifa Zhou ◽  
...  
Keyword(s):  
Photoacoustic Microscopy ◽  
Reflection Mode ◽  
Submicron Resolution
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