scholarly journals Bloch surface wave enhanced biosensor for the direct detection of Angiopoietin-2 tumor biomarker in human plasma

2018 ◽  
Vol 9 (2) ◽  
pp. 529 ◽  
Author(s):  
Riccardo Rizzo ◽  
Maria Alvaro ◽  
Norbert Danz ◽  
Lucia Napione ◽  
Emiliano Descrovi ◽  
...  
Keyword(s):  
Surface Wave ◽  
Human Plasma ◽  
Direct Detection ◽  
Tumor Biomarker ◽  
Bloch Surface Wave ◽  
Angiopoietin 2

Bloch surface wave-enhanced fluorescence biosensor

2013 ◽  
Vol 43 ◽  
pp. 108-114 ◽  
Author(s):  
Koji Toma ◽  
Emiliano Descrovi ◽  
Mana Toma ◽  
Mirko Ballarini ◽  
Pietro Mandracci ◽  
...  
Keyword(s):  
Surface Wave ◽  
Enhanced Fluorescence ◽  
Bloch Surface Wave ◽  
Fluorescence Biosensor

scholarly journals High performance liquid analyte sensing based on Bloch surface wave resonances in the spectral domain

2022 ◽  
Vol 145 ◽  
pp. 107492
Author(s):  
P. Hlubina ◽  
M. Gryga ◽  
D. Ciprian ◽  
P. Pokorny ◽  
L. Gembalova ◽  
...  
Keyword(s):  
Surface Wave ◽  
High Performance ◽  
Spectral Domain ◽  
Bloch Surface Wave

scholarly journals Bloch Surface Wave Resonance Based Sensors as an Alternative to Surface Plasmon Resonance Sensors

Sensors ◽  
2020 ◽  
Vol 20 (18) ◽  
pp. 5119 ◽  
Author(s):  
Michal Gryga ◽  
Dalibor Ciprian ◽  
Petr Hlubina
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Wave ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Moist Air ◽  
Polarized Waves ◽  
Wave Resonance ◽  
Highly Sensitive ◽  
Bloch Surface Wave ◽  
Spr Effect

We report on a highly sensitive measurement of the relative humidity (RH) of moist air using both the surface plasmon resonance (SPR) and Bloch surface wave resonance (BSWR). Both resonances are resolved in the Kretschmann configuration when the wavelength interrogation method is utilized. The SPR is revealed for a multilayer plasmonic structure of SF10/Cr/Au, while the BSWR is resolved for a multilayer dielectric structure (MDS) comprising four bilayers of TiO2/SiO2 with a rough termination layer of TiO2. The SPR effect is manifested by a dip in the reflectance of a p-polarized wave, and a shift of the dip with the change in the RH, or equivalently with the change in the refractive index of moist air is revealed, giving a sensitivity in a range of 0.042–0.072 nm/%RH. The BSWR effect is manifested by a dip in the reflectance of the spectral interference of s- and p-polarized waves, which represents an effective approach in resolving the resonance with maximum depth. For the MDS under study, the BSWRs were resolved within two band gaps, and for moist air we obtained sensitivities of 0.021–0.038 nm/%RH and 0.046–0.065 nm/%RH, respectively. We also revealed that the SPR based RH measurement is with the figure of merit (FOM) up to 4.7 × 10−4 %RH−1, while BSWR based measurements have FOMs as high as 3.0 × 10−3 %RH−1 and 1.1 × 10−3 %RH−1, respectively. The obtained spectral interferometry based results demonstrate that the BSWR based sensor employing the available MDS has a similar sensitivity as the SPR based sensor, but outperforms it in the FOM. BSW based sensors employing dielectrics thus represent an effective alternative with a number of advantages, including better mechanical and chemical stability than metal films used in SPR sensing.

scholarly journals Monitoring of Irinotecan in Human Plasma: Sensitive Fluorescent Nanogels by Molecular Imprinting

2019 ◽  
Author(s):  
Martina Tommasini ◽  
Elena Pellizzoni ◽  
Valentina Iacuzzi ◽  
Elena Marangon ◽  
Paola Posocco ◽  
...  
Keyword(s):  
Amino Acids ◽  
Fluorescence Quenching ◽  
Human Plasma ◽  
Molecular Imprinting ◽  
Plasma Sample ◽  
Direct Detection ◽  
Fluorescent Nanoparticles ◽  
High Dilution ◽  
Molecularly Imprinted

A series of fluorescent molecularly imprinted nanogels to detect irinotecan (CPT11) were prepared and characterized. A set of amino acids and napthalimide polymerisable derivatives allowed to obtain polymers as soluble fluorescent nanoparticles by high dilution imprinted synthesis. The direct detection of irinotecan in human plasma was obtained by fluorescence quenching of the naphtalimide-based imprinted materials. The plasma sample treated with acetonitrile allowed the detection of irinotecan in the 10nM – 30μM range. The LOD was 9.4 nM, with within-run variability 10% and day to day variability 13%.<br>

scholarly journals Unidirectional propagation of the Bloch surface wave excited by the spinning magnetic dipole in two-dimensional photonic crystal slab

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Li-Ming Zhao ◽  
Yun-Song Zhou
Keyword(s):  
Photonic Crystal ◽  
Surface Wave ◽  
Magnetic Dipole ◽  
Incident Light ◽  
Polarization State ◽  
Oscillation Period ◽  
Unit Cell ◽  
Average Spin ◽  
Component Wave ◽  
Bloch Surface Wave

AbstractThe photonic spin Hall effect (PSHE) can be realized in a photonic crystal (PC) slab, that is, the unidirectional Bloch surface wave can propagate along the surface of the PC slab under the excitation of elliptical polarized magnetic dipole. It is further proved that PSHE is caused by the interference of the component surface waves excited by the different components of the incident light, which is the so called component wave interference (CWI) theory. In addition, we also find that the spin of the surface wave oscillates periodically in space, and the oscillation period is a unit cell. In a unit cell, the average spin keeps the spin orbit locked. The results show that the spin separation can also be modulated by the position and the polarization state of the magnetic dipole.

Combining label-free and fluorescence operation of Bloch surface wave optical sensors

2014 ◽  
Vol 39 (10) ◽  
pp. 2947 ◽  
Author(s):  
Alberto Sinibaldi ◽  
Antonio Fieramosca ◽  
Riccardo Rizzo ◽  
Aleksei Anopchenko ◽  
Norbert Danz ◽  
...  
Keyword(s):  
Surface Wave ◽  
Optical Sensors ◽  
Label Free ◽  
Bloch Surface Wave

Phase-sensitive Bloch Surface Wave sensing

2014 ◽  
Author(s):  
Yuhang Wan ◽  
Liya Shu ◽  
Xuekun Zhu ◽  
Zheng Zheng
Keyword(s):  
Surface Wave ◽  
Phase Sensitive ◽  
Bloch Surface Wave

High-Sensitivity Bloch Surface Wave Sensor with Fano Resonance in Grating-coupled Multilayer Structures

2021 ◽  
Author(s):  
Daohan Ge ◽  
Yujie Zhou ◽  
Mengcheng Lv ◽  
Jiakang Shi ◽  
Abubakar A. Babangida ◽  
...  
Keyword(s):  
Surface Wave ◽  
Fano Resonance ◽  
High Sensitivity ◽  
Multilayer Structures ◽  
Bloch Surface Wave

scholarly journals Bloch surface wave-coupled emission from quantum dots by ensemble and single molecule spectroscopy

RSC Advances ◽  
2015 ◽  
Vol 5 (67) ◽  
pp. 54403-54411 ◽  
Author(s):  
Krishanu Ray ◽  
Ramachandram Badugu ◽  
Joseph R. Lakowicz
Keyword(s):  
Quantum Dots ◽  
Photonic Crystal ◽  
Surface Wave ◽  
Single Molecule ◽  
Single Molecule Spectroscopy ◽  
One Dimensional ◽  
Fluorescence Studies ◽  
Emission Lifetime ◽  
Crystal Substrate ◽  
Bloch Surface Wave

Single particle fluorescence studies demonstrate increased brightness and reduced emission lifetime of individual QD575 on one-dimensional photonic crystal substrate.

Factor XIII activation peptide is released into plasma upon cleavage by thrombin and shows a different structure compared to its bound form

2007 ◽  
Vol 97 (06) ◽  
pp. 890-898 ◽  
Author(s):  
Verena Schroeder ◽  
Jean-Marc Vuissoz ◽  
Amedeo Caflisch ◽  
Hans Kohler
Keyword(s):  
Human Plasma ◽  
Factor Xiii ◽  
Direct Detection ◽  
Polyclonal Antibodies ◽  
Coagulation Factor ◽  
Highly Sensitive ◽  
Clinical Interest ◽  
Activation Peptide ◽  
Dynamics Simulations

SummaryThe first step of coagulation factor XIII (FXIII) activation involves cleavage of the FXIII activation peptide (FXIII-AP) by thrombin. However, it is not known whether the FXIII-AP is released into plasma upon cleavage or remains attached to activated FXIII. The aim of the present work was to study the structure of free FXIII-AP, develop an assay for FXIII-AP determination in human plasma, and to answer the question whether FXIII-AP is released into plasma. We used ab-initio modeling and molecular dynamics simulations to study the structure of free FXIII-AP. We raised monoclonal and polyclonal antibodies against FXIII-AP and developed a highly sensitive and specific ELISA method for direct detection of FXIII-AP in human plasma. Structural analysis showed a putative different conformation of the free FXIII-AP compared to FXIII-AP bound to the FXIII protein. We concluded that it might be feasible to develop specific antibodies against the free FXIII-AP. Using our new FXIII-AP ELISA, we found high levels of FXIII-AP in in-vitro activated plasma samples and serum. We showed for the first time that FXIIIAP is detached from activated FXIII and is released into plasma, where it can be directly measured. Our findings may be of major clinical interest in regard to a possible new marker in thrombotic disease.

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