Accuracy of retrieving optical properties fromliquid tissue phantoms using a singleintegrating sphere

2021 ◽  
Author(s):  
Vinoin Devpaul Vincely ◽  
Karthik Vishwanath
Keyword(s):  
Optical Properties ◽  
Tissue Phantoms

scholarly journals Multi-layered tissue head phantoms for noninvasive optical diagnostics

2015 ◽  
Vol 08 (03) ◽  
pp. 1541005 ◽  
Author(s):  
M. S. Wróbel ◽  
A. P. Popov ◽  
A. V. Bykov ◽  
M. Kinnunen ◽  
M. Jędrzejewska-Szczerska ◽  
...  
Keyword(s):  
Optical Properties ◽  
Near Infrared ◽  
Optical Measurement ◽  
Human Head ◽  
Medical Diagnostics ◽  
Optical Parameters ◽  
Measurement Systems ◽  
Tissue Phantoms ◽  
Optical And Mechanical Properties

Extensive research in the area of optical sensing for medical diagnostics requires development of tissue phantoms with optical properties similar to those of living human tissues. Development and improvement of in vivo optical measurement systems requires the use of stable tissue phantoms with known characteristics, which are mainly used for calibration of such systems and testing their performance over time. Optical and mechanical properties of phantoms depend on their purpose. Nevertheless, they must accurately simulate specific tissues they are supposed to mimic. Many tissues and organs including head possess a multi-layered structure, with specific optical properties of each layer. However, such a structure is not always addressed in the present-day phantoms. In this paper, we focus on the development of a plain-parallel multi-layered phantom with optical properties (reduced scattering coefficient [Formula: see text] and absorption coefficient μa) corresponding to the human head layers, such as skin, skull, and gray and white matter of the brain tissue. The phantom is intended for use in noninvasive diffuse near-infrared spectroscopy (NIRS) of human brain. Optical parameters of the fabricated phantoms are reconstructed using spectrophotometry and inverse adding-doubling calculation method. The results show that polyvinyl chloride-plastisol (PVCP) and zinc oxide ( ZnO ) nanoparticles are suitable materials for fabrication of tissue mimicking phantoms with controlled scattering properties. Good matching was found between optical properties of phantoms and the corresponding values found in the literature.

scholarly journals Discovering new 3D bioprinting applications: Analyzing the case of optical tissue phantoms

2018 ◽  
Vol 5 (1) ◽  
Author(s):  
Marisela Rodriguez-Salvador
Keyword(s):  
Optical Properties ◽  
3D Printing ◽  
Clinical Training ◽  
Three Dimensional ◽  
Biological Tissues ◽  
3D Bioprinting ◽  
Technology Intelligence ◽  
Biomedical Device ◽  
Tissue Phantoms ◽  
Scientific Papers

Optical tissue phantoms enable to mimic the optical properties of biological tissues for biomedical device calibration, new equipment validation, and clinical training for the detection, and treatment of diseases. Unfortunately, current methods for their development present some problems, such as a lack of repeatability in their optical properties. Where the use of three-dimensional (3D) printing or 3D bioprinting could address these issues. This paper aims to evaluate the use of this technology in the development of optical tissue phantoms. A competitive technology intelligence methodology was applied by analyzing Scopus, Web of Science, and patents from January 1, 2000, to July 31, 2018. The main trends regarding methods, materials, and uses, as well as predominant countries, institutions, and journals, were determined. The results revealed that, while 3D printing is already employed (in total, 108 scientific papers and 18 patent families were identified), 3D bioprinting is not yet applied for optical tissue phantoms. Nevertheless, it is expected to have significant growth. This research gives biomedical scientists a new window of opportunity for exploring the use of 3D bioprinting in a new area that may support testing of new equipment and development of techniques for the diagnosis and treatment of diseases.

scholarly journals Determination of Optical Properties of Superficial Volumes of Layered Tissue Phantoms

2008 ◽  
Vol 55 (1) ◽  
pp. 335-339 ◽  
Author(s):  
Sheng-Hao Tseng ◽  
Carole Hayakawa ◽  
Jerome Spanier ◽  
Anthony J. Durkin
Keyword(s):  
Optical Properties ◽  
Tissue Phantoms

scholarly journals Studying the distribution of deep Raman spectroscopy signals using liquid tissue phantoms with varying optical properties

The Analyst ◽  
2015 ◽  
Vol 140 (15) ◽  
pp. 5112-5119 ◽  
Author(s):  
Martha Z. Vardaki ◽  
Benjamin Gardner ◽  
Nicholas Stone ◽  
Pavel Matousek
Keyword(s):  
Raman Spectroscopy ◽  
Optical Properties ◽  
Tissue Phantoms ◽  
Transmission Raman

We studied experimentally the magnitude and origin of Raman signals in a transmission Raman geometry as a function of optical properties of the medium and the location of Raman scatterer within the phantom.

scholarly journals On the quantitative optical properties of Au nanoparticles embedded in biological tissue phantoms

2021 ◽  
Vol 114 ◽  
pp. 110924
Author(s):  
J.C.R. Araújo ◽  
A.F.G. Monte ◽  
R. Lora-Serrano ◽  
W. Iwamoto ◽  
A. Antunes ◽  
...  
Keyword(s):  
Optical Properties ◽  
Biological Tissue ◽  
Au Nanoparticles ◽  
Tissue Phantoms

scholarly journals Effect of dependent scattering on the optical properties of Intralipid tissue phantoms

2011 ◽  
Vol 2 (8) ◽  
pp. 2265 ◽  
Author(s):  
Paola Di Ninni ◽  
Fabrizio Martelli ◽  
Giovanni Zaccanti
Keyword(s):  
Optical Properties ◽  
Tissue Phantoms

scholarly journals Exfoliation and Optical Properties of Near-Infrared Fluorescent Silicate Nanosheets

2021 ◽  
Author(s):  
Gabriele Selvaggio ◽  
Milan Weitzel ◽  
Nazar Oleksiievets ◽  
Tabea A. Oswald ◽  
Robert Nißler ◽  
...  
Keyword(s):  
Optical Properties ◽  
Near Infrared ◽  
Photophysical Properties ◽  
Fluorescence Lifetime Imaging ◽  
Fluorescence Lifetimes ◽  
Macroscopic Scale ◽  
Remote Imaging ◽  
Lifetime Imaging ◽  
Tissue Phantoms ◽  
Nir Fluorescence

<div><div><div><p>The silicates Egyptian Blue (CaCuSi4O10, EB), Han Blue (BaCuSi4O10, HB) and Han Purple (BaCuSi2O6, HP) emit in bulk bright and stable fluorescence in the near-infrared (NIR), which is of high interest for (bio)photonics due to minimal scattering, absorption and phototoxicity in this spectral range. So far the optical properties of nanosheets (NS) of these silicates are poorly understood. Here, we exfoliate them into nanosheets and report their physicochemical properties. The approach uses ball milling followed by tip sonication and centrifugation steps to exfoliate the silicates into NS with a lateral size ≈ 16-27 nm and thickness ≈ 1-4 nm. They emit at ≈ 927 nm (EB-NS), 953 nm (HB-NS) and 924 nm (HP-NS) and single NS can be resolved in the NIR. Fluorescence lifetimes decrease from ≈ 30-100 μs (bulk) to 17 μs (EB- NS), 8 μs (HB-NS) and 7 μs (HP-NS). NS of different composition/size can be imaged by fluorescence lifetime imaging, which enables lifetime-encoded multicolor imaging both on the microscopic and the macroscopic scale. Finally, remote imaging through tissue phantoms reveals the potential for bioimaging. In summary, we report a procedure to gain NIR fluorescent silicate nanosheets, characterize their photophysical properties and show their potential for NIR photonics.</p></div></div></div>

scholarly journals Exfoliation and Optical Properties of Near-Infrared Fluorescent Silicate Nanosheets

2021 ◽  
Author(s):  
Gabriele Selvaggio ◽  
Milan Weitzel ◽  
Nazar Oleksiievets ◽  
Tabea A. Oswald ◽  
Robert Nißler ◽  
...  
Keyword(s):  
Optical Properties ◽  
Near Infrared ◽  
Photophysical Properties ◽  
Fluorescence Lifetime Imaging ◽  
Fluorescence Lifetimes ◽  
Macroscopic Scale ◽  
Remote Imaging ◽  
Lifetime Imaging ◽  
Tissue Phantoms ◽  
Nir Fluorescence

<div><div><div><p>The silicates Egyptian Blue (CaCuSi4O10, EB), Han Blue (BaCuSi4O10, HB) and Han Purple (BaCuSi2O6, HP) emit in bulk bright and stable fluorescence in the near-infrared (NIR), which is of high interest for (bio)photonics due to minimal scattering, absorption and phototoxicity in this spectral range. So far the optical properties of nanosheets (NS) of these silicates are poorly understood. Here, we exfoliate them into nanosheets and report their physicochemical properties. The approach uses ball milling followed by tip sonication and centrifugation steps to exfoliate the silicates into NS with a lateral size ≈ 16-27 nm and thickness ≈ 1-4 nm. They emit at ≈ 927 nm (EB-NS), 953 nm (HB-NS) and 924 nm (HP-NS) and single NS can be resolved in the NIR. Fluorescence lifetimes decrease from ≈ 30-100 μs (bulk) to 17 μs (EB- NS), 8 μs (HB-NS) and 7 μs (HP-NS). NS of different composition/size can be imaged by fluorescence lifetime imaging, which enables lifetime-encoded multicolor imaging both on the microscopic and the macroscopic scale. Finally, remote imaging through tissue phantoms reveals the potential for bioimaging. In summary, we report a procedure to gain NIR fluorescent silicate nanosheets, characterize their photophysical properties and show their potential for NIR photonics.</p></div></div></div>

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