scholarly journals Tissue enhanced optical imaging and monitoring of drug delivery

2012 ◽  
Author(s):  
Valery V. Tuchin
Keyword(s):  
Drug Delivery ◽  
Optical Imaging

scholarly journals Investigation of an Optical Imaging Platform Integrated with an Ultrasound Application System for In Vitro Verification of Ultrasound-Mediated Drug Delivery

2021 ◽  
Vol 11 (6) ◽  
pp. 2846
Author(s):  
Jong-ryul Choi ◽  
Juyoung Park
Keyword(s):  
Drug Delivery ◽  
Cervical Cancer ◽  
Cell Membrane ◽  
Optical Imaging ◽  
Cancer Cell ◽  
Fluorescent Imaging ◽  
Calcium Flux ◽  
Cervical Cancer Cell ◽  
Application System ◽  
Ultrasound Application

Techniques that increase the permeability of the cell membrane and transfer drugs or genes to cells have been actively developed as effective therapeutic modalities. Also, in line with the development of these drug delivery techniques, the establishment of tools to verify the techniques at the cellular level is strongly required. In this study, we demonstrated an optical imaging platform integrated with an ultrasound application system to verify the feasibility of safe and efficient drug delivery through the cell membrane using ultrasound-microbubble cavitation. To examine the potential of the platform, fluorescence images of both Fura-2 AM and propidium iodide (PI) to measure calcium flux changes and intracellular PI delivery, respectively, during and after the ultrasound-microbubble cavitation in the cervical cancer cell were acquired. Using the optical imaging platform, we determined that calcium flux increased immediately after the ultrasound-microbubble cavitation and were restored to normal levels, and fluorescence signals from intracellular PI increased gradually after the cavitation. The results acquired by the platform indicated that ultrasound-microbubble cavitation can deliver PI into the cervical cancer cell without irreversible damage of the cell membrane. The application of an additional fluorescent imaging module and high-speed imaging modalities can provide further improvement of the performance of this platform. Also, as additional studies in ultrasound instrumentations to measure real-time cavitation signals progress, we believe that the ultrasound-microbubble cavitation-based sonoporation can be employed for safe and efficient drug and gene delivery to various cancer cells.

Smart polymeric particle encapsulated gadolinium oxide and europium: theranostic probes for magnetic resonance/optical imaging and antitumor drug delivery

2016 ◽  
Vol 4 (6) ◽  
pp. 1100-1107 ◽  
Author(s):  
Ruiqing Liu ◽  
Shuang Liang ◽  
Cun Jiang ◽  
Li Zhang ◽  
Tianmeng Yuan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Optical Imaging ◽  
Emulsion Polymerization ◽  
Gadolinium Oxide ◽  
Antitumor Drug ◽  
Ph Responsive ◽  
Polymeric Particles ◽  
Polymeric Particle

Paramagnetic, luminescent, and temperature/pH-responsive polymeric particles with MR/optical imaging and antitumor drug delivery capability are prepared by emulsifier-free emulsion polymerization.

scholarly journals On the Emission Properties of Carbon Dots: Reviewing Data and Discussing Models

2019 ◽  
Vol 5 (4) ◽  
pp. 60 ◽  
Author(s):  
Carbonaro ◽  
Corpino ◽  
Salis ◽  
Mocci ◽  
Thakkar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Green Chemistry ◽  
Optical Imaging ◽  
Carbon Dots ◽  
High Efficiency ◽  
Cell Labelling ◽  
Emission Properties ◽  
Potential Applications ◽  
Bio Imaging

The emission properties of carbon dots (CDs) have already found many potential applications, from bio-imaging and cell labelling, to optical imaging and drug delivery, and are largely investigated in technological fields, such as lighting and photonics. Besides their high efficiency emission, CDs are also virtually nontoxic and can be prepared through many green chemistry routes. Despite these important features, the very origin of their luminescence is still debated. In this paper, we present an overview of sounding data and the main models proposed to explain the emission properties of CDs and their tunability.

Fluorescence optical imaging in anticancer drug delivery

2016 ◽  
Vol 226 ◽  
pp. 168-181 ◽  
Author(s):  
Tomáš Etrych ◽  
Henrike Lucas ◽  
Olga Janoušková ◽  
Petr Chytil ◽  
Thomas Mueller ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Imaging ◽  
Anticancer Drug ◽  
Fluorescence Optical Imaging ◽  
Anticancer Drug Delivery

Inorganic Nanovehicle for Potential Targeted Drug Delivery to Tumor Cells, Tumor Optical Imaging

2015 ◽  
Vol 7 (9) ◽  
pp. 5089-5096 ◽  
Author(s):  
Shiyong Yu ◽  
Xuechuan Gao ◽  
Huricha Baigude ◽  
Xiao Hai ◽  
Renfei Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Imaging ◽  
Tumor Cells ◽  
Targeted Drug Delivery ◽  
Targeted Drug

scholarly journals Optical imaging and analysis of human vaginal coating by drug delivery gels

Contraception ◽  
2007 ◽  
Vol 75 (2) ◽  
pp. 142-151 ◽  
Author(s):  
Marcus H. Henderson ◽  
Grace M. Couchman ◽  
David K. Walmer ◽  
Jennifer J. Peters ◽  
Derek H. Owen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Imaging

In situ growth of metal–organic frameworks (MOFs) on the surface of other MOFs: a new strategy for constructing magnetic resonance/optical dual mode imaging materials

2017 ◽  
Vol 46 (40) ◽  
pp. 13686-13689 ◽  
Author(s):  
Xuechuan Gao ◽  
Guanfeng Ji ◽  
Ruixue Cui ◽  
Jingjuan Liu ◽  
Zhiliang Liu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Optical Imaging ◽  
Metal Organic Frameworks ◽  
In Situ Growth ◽  
Dual Mode ◽  
New Strategy ◽  
Metal Organic ◽  
First Time

This work presents for the first time the synthesis of a novel nanoscale Fe-MOF/Eu-MOF heterostructure, which exhibits excellent magnetic resonance/optical imaging capacity and satisfactory drug delivery behavior.

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